The human genome project was a major advance, allowing for molecular foothold towards an understanding of human diseases. The question now is “what do these genes do, and how do they participate in human disease?” In my lab we are focused on this issue. We use whole genome, functional in vivo screening in the fruit fly to identify novel conserved disease genes, then we use human genetics data to focus on medically relevant candidates, finally we use knockout mice to functionally validate these n ....The human genome project was a major advance, allowing for molecular foothold towards an understanding of human diseases. The question now is “what do these genes do, and how do they participate in human disease?” In my lab we are focused on this issue. We use whole genome, functional in vivo screening in the fruit fly to identify novel conserved disease genes, then we use human genetics data to focus on medically relevant candidates, finally we use knockout mice to functionally validate these new genesRead moreRead less
Clinical Approaches To Preventing Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
Cardiovascular disease (CVD) is the leading cause of death and disease burden globally. While many new treatments have been discovered in the last few decades to prevent CVD, surveys show many people do not receive these treatments. Dr. Chow is committed to using her skills as a cardiologist and a researcher to bridge this gap. Her program aims to identify novel, simple and scalable approaches to decrease the gap in preventative care and reduce the burden of CVD in Australia and beyond.
Improving Prevention Of Cardiovascualr Disease In High Risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Heart attack and stroke are the leading causes of death and disease burden globally. While there are highly effective treatments to prevent cardiovascular disease, surveys in Australia and other parts of the world indicate they are not being taken up. This program of research aims to improve prevention in individuals at high risk of heart attack and stroke by developing and testing strategies to increase the use of effective evidence-based treatment therapies.
Overcoming Breast Cancer Heterogeneity And Resistance Using A Novel Therapeutic Approach Targeting The Metastasis Suppressor NDRG1.
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Breast cancer (BrCa) is the leading cause of cancer death in women and current treatments suffer from development of resistance, leading to metastatic progression. I will assess a novel treatment strategy for BrCa, targeting a gene that is able to inhibit multiple key drivers of BrCa, using a novel potent and selective anti-cancer agent. This approach has the potential to overcome resistance to current therapies and alleviate the onset of metastasis, to improve prognosis for BrCa patients.
Central Blood Pressure And Cardiovascular Risk In Children Within The General Population And After Repair Of Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
With an exceptional research standing internationally, and as the leader of a Cardiovascular Bioengineering team, I am developing a new method for assessing central blood pressure in children that will provide better information about early risk of cardiovascular disease than arm blood pressure. This will be applied (1) in a large health study of Australian children and (2) to identify risks and causes of adult-type cardiovascular disease in children with repaired congenital heart disease.