In a human body, about a million cells are born every second, and a million die by activating a physiological cell death mechanism. If cell death fails to occur, cells accumulate and can develop into cancers. Determining the mechanism and regulation of physiological cell death will provide novel approaches to treat cancers and auto-immune diseases, both of which are characterised by failure of certain cells to die.
Regulation Of Cell Death, Cell Survival And Ubiquitination In Normal Physiology And Disease
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
The project will investigate the functions of specific genes and pathways to understand the molecular basis of various diseases. It is based on our data that indicate new roles for (i) cell death in genomic instability in cancer, and (ii) ubiquitination in hypertension, developmental defects, kidney disease, as well as iron homeostasis. The work will lead to new understanding of human disease and discovery of potential new drug targets. It will also provide training of junior scientists.
Regulation Of Cell Death, Cell Survival And Ubiquitination In Normal Physiology And Disease
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
I am a cellular and molecular biologist with extensive training in a number of biomedical research areas. For over 20 years I have used my training and skills to understand the normal functioning of the body and what molecular and cellular changes underlie various diseases. This fellowship will allow me to continue the groundbreaking work we have been doing to explore the function of several proteins in diseases such as cancer, hypertension, lung inflammation and anaemia.