Before and after the Last Ice Age: GunaiKurnai archaeology along the Snowy. This project aims to transform our understanding of the deep-time Aboriginal occupation of Victoria's Snowy River landscape, by excavating a network of sites dating back to >52,000 years. This project expects to generate new knowledge in archaeology and palaeoclimatology through partnership research in Gunaikurnai Country. Expected outcomes of this project include unprecedented details of Aboriginal occupation, ritual in ....Before and after the Last Ice Age: GunaiKurnai archaeology along the Snowy. This project aims to transform our understanding of the deep-time Aboriginal occupation of Victoria's Snowy River landscape, by excavating a network of sites dating back to >52,000 years. This project expects to generate new knowledge in archaeology and palaeoclimatology through partnership research in Gunaikurnai Country. Expected outcomes of this project include unprecedented details of Aboriginal occupation, ritual installations, wooden artefacts, ancient human DNA, use of deep caves and open landscapes, and economic strategies dating back to the Last Ice Age and beyond. This should provide significant benefits in community research, greater social understandings of Aboriginal connections with Country, and a more inclusive Australia.Read moreRead less
LGBTQ Migrations: Life Story Narratives in the South Australian GLAM Sector. This project investigates the role gender and sexual diversity play in migration and mobility to South Australia 1950-1999 and how stories of migration can be collected and preserved. Histories in relation to interstate, international, and global migration into South Australia exist, however there is a significant need to address the lack of knowledge on, and record of, how minority sexuality and gender influenced movin ....LGBTQ Migrations: Life Story Narratives in the South Australian GLAM Sector. This project investigates the role gender and sexual diversity play in migration and mobility to South Australia 1950-1999 and how stories of migration can be collected and preserved. Histories in relation to interstate, international, and global migration into South Australia exist, however there is a significant need to address the lack of knowledge on, and record of, how minority sexuality and gender influenced moving to South Australia. Limited information prevents a full understanding of migration histories. This project works with the History Trust of South Australia to address a recognised and strategic need for greater inclusiveness of gender and sexual diversity in the context of migration. Read moreRead less
Defining the Status of Culturally and Linguistically Diverse Young People. This project aims to improve the social cohesion of Australian society and the living standards of a significant group of our young people. Around 25 per cent of all Australians aged 12 to 24 are from culturally and linguistically diverse (CALD) backgrounds. In collaboration with nine Australian organisations, the project aims to critically define the status of CALD youth; develop the first national status reporting frame ....Defining the Status of Culturally and Linguistically Diverse Young People. This project aims to improve the social cohesion of Australian society and the living standards of a significant group of our young people. Around 25 per cent of all Australians aged 12 to 24 are from culturally and linguistically diverse (CALD) backgrounds. In collaboration with nine Australian organisations, the project aims to critically define the status of CALD youth; develop the first national status reporting framework for the group that will generate new social, economic and cultural indicators; and build a knowledge hub to store and curate CALD youth data. Data and understanding from this project is intended to enable governments to meet the group’s specific needs and enhance their opportunities.Read moreRead less
Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level ....Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level of the individual to isolated enteroendocrine cells.Read moreRead less
Determining the regulation of vitamin D metabolism. The proposed project will lead to a better understanding of factors that influence the biological function of vitamin D. This will impact in several areas of human health and will provide new avenues for the development of preventative approaches and treatment of cancer. This project is based on the use of 'Frontier Technologies' that will be applied to elucidate basic biological questions.
Australian cultural and creative activity: A population and hotspot analysis. This project aims to grasp the contemporary dynamics of cultural and creative activity in Australia. It represents a major innovation, bringing together population-level and comparative studies of local cultural and creative activity. The comprehensive project will advance the integration of quantitative and qualitative research strategies, painting a complete national picture, while also exploring the factors that are ....Australian cultural and creative activity: A population and hotspot analysis. This project aims to grasp the contemporary dynamics of cultural and creative activity in Australia. It represents a major innovation, bringing together population-level and comparative studies of local cultural and creative activity. The comprehensive project will advance the integration of quantitative and qualitative research strategies, painting a complete national picture, while also exploring the factors that are producing local and regional creative hotspots. The project will deliver outputs such as reports and forums that are framed in close collaboration with partners in order to deliver outcomes such as better-targeted policy and program initiatives. This will provide national cultural and policy benefits from placing the creative sector in front of policy makers as a vital contributor to high growth, labour-intensive economic activity in the context of the Australian economy in transition.Read moreRead less
New approaches measuring Australia’s creative workforce: Beyond the Census . This project aims to develop new approaches to measuring Australia’s creative workforce to address increasingly urgent questions about the value of this growing but poorly understood part of the economy and society. It expects to develop and demonstrate novel methods for capturing a range of creative activity currently at the margins of traditional measurement typified by the Census. Expected outcomes, which will benefi ....New approaches measuring Australia’s creative workforce: Beyond the Census . This project aims to develop new approaches to measuring Australia’s creative workforce to address increasingly urgent questions about the value of this growing but poorly understood part of the economy and society. It expects to develop and demonstrate novel methods for capturing a range of creative activity currently at the margins of traditional measurement typified by the Census. Expected outcomes, which will benefit industry partners, the cultural and creative industries, and international scholarship, include new understandings of the scope of creative qualifications, the contribution of creatives working outside the creative industries, the extent of second and other incomes, and the value of volunteering and online entrepreneurship.Read moreRead less
An exploration of the frequency, outcomes, enablers and constraints of bystander anti-racism. Bystander anti-racism involves ordinary people speaking up and taking prosocial action when witnessing racism. This project will develop empirical understandings of this underexplored, yet potentially powerful, form of anti-racism, including its frequency, the outcome of action, and factors that enable and constrain bystander anti-racism.
The mechanisms and roles of receptor clustering in cell activation and wound healing by growth factors. Growth factors regulate cell proliferation, migration and differentation by interaction with receptors. Such receptors are usually localized at the cell surface, and require intracellular transduction systems to transmit the signal to the cell interior. We have recently shown the hormone-induced clustering of heterologous hormone receptors in cells, and that this occurs with the co-clustering ....The mechanisms and roles of receptor clustering in cell activation and wound healing by growth factors. Growth factors regulate cell proliferation, migration and differentation by interaction with receptors. Such receptors are usually localized at the cell surface, and require intracellular transduction systems to transmit the signal to the cell interior. We have recently shown the hormone-induced clustering of heterologous hormone receptors in cells, and that this occurs with the co-clustering of downstream signalling molecules at sites of engagement with the extracellular matrix. In addition, we have found that cells presented with an extracellular matrix respond better to subsequent growth factor stimulation. The project aims to determine the cellular mechanisms underlying receptor clustering and the basis of the receptor-extracellular matrix interaction. This will enhance our understanding of growth factor function in a number of conditions, including wound healing. We will extend our in vitro results to the animal model to define parameters for enhanced wound repair.Read moreRead less
Differentiation of Cord Blood Stem cells into Thymus (T) cells with regulatory phenotype and function. This project will develop technologies for a stem cell therapy platform based on cord blood stem cells, to enable treatment of autoimmune diseases or transplants. Building on the University of Adelaide's frontier demonstration of differentiation of regulatory Thymus (T) cells from cord blood stem cells, the project will develop techniques to expand the numbers of T cells generated. This has the ....Differentiation of Cord Blood Stem cells into Thymus (T) cells with regulatory phenotype and function. This project will develop technologies for a stem cell therapy platform based on cord blood stem cells, to enable treatment of autoimmune diseases or transplants. Building on the University of Adelaide's frontier demonstration of differentiation of regulatory Thymus (T) cells from cord blood stem cells, the project will develop techniques to expand the numbers of T cells generated. This has the potential to maintain Australia's lead in differentiation of cord blood stem cells and to provide a significant breakthrough in potential treatments of autoimmune diseases (e.g. type 1 diabetes) or transplantation. These diseases affect both a healthy start to life and healthy ageing, and an Australian invention to treat or cure them would have global impact.Read moreRead less