Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internatio ....Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internationalisation strategies and consumption of Chinese culture on digital platforms in China, Australia, Hong Kong, Singapore and South Korea. It expects to understand the implications of China's digital ascendency and the lessons for Australia in the post-resources boom era.Read moreRead less
The social dynamics of language: a study of phonological variation and change in West Australian English. This project studies the role of pronunciation as a marker of individual and community identity. As the first systematic study of accent variability in Perth, it focusses on how, across different contexts, speakers from older and younger generations and different backgrounds deploy speech as a means of projecting social affiliation and difference.
The Ancient Today: Living Traditions of Classical Language Education. This project aims to compare, for the first time, ancient language education across world cultures with ‘classical’ literatures. It expects to illumine the purpose and value of classical language education in Chinese, Greek, Latin, and Sanskrit historically and within global education systems today by comparing pedagogic ideals and practices across times and cultures. It aims to test the potential of inclusive classical langua ....The Ancient Today: Living Traditions of Classical Language Education. This project aims to compare, for the first time, ancient language education across world cultures with ‘classical’ literatures. It expects to illumine the purpose and value of classical language education in Chinese, Greek, Latin, and Sanskrit historically and within global education systems today by comparing pedagogic ideals and practices across times and cultures. It aims to test the potential of inclusive classical language learning to boost educational outcomes for disadvantaged students. Other expected outcomes include two books, scholarly articles, education policy reports, and PhD student training. This should strengthen intercultural understanding and benefit school students, educators, policy makers and the wider public.Read moreRead less
Willing collaborators: Negotiating Change in East Asian Media Production. This project examines how media producers and investors from China, Korea, Taiwan, and Hong Kong are moving into flexible and innovative forms of collaboration. Focusing on cinema, television, online video and mobile content in East Asia, the study enhances academic, industry and policy understandings of the dynamics of regional media production. In addition, the project investigates opportunities and challenges for Austra ....Willing collaborators: Negotiating Change in East Asian Media Production. This project examines how media producers and investors from China, Korea, Taiwan, and Hong Kong are moving into flexible and innovative forms of collaboration. Focusing on cinema, television, online video and mobile content in East Asia, the study enhances academic, industry and policy understandings of the dynamics of regional media production. In addition, the project investigates opportunities and challenges for Australian and other international media companies. It addresses the urgent need to foster understanding of the media industries and cultures of Australia's regional neighbours in order to better equip the nation and its screen sectors to participate in the forthcoming "Asian Century". Read moreRead less
CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research wil ....CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research will provide new data on the fundamental cellular and molecular events that are required to trigger the birth, differentiation and conditions for growth of new neurons in the adult nervous system. The generation of such insights will be critical for any translational research.
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The Illustrated Literature of Papunya and Strelley, 1979-1998. Literature Production Centres at Papunya and Strelley (WA) published hundreds of illustrated books during the 1970s, 1980s and 1990s. They tell stories of the first contact, the Dreaming, bush plants, animals and life on pastoral stations, missions, government settlements and communities. This project will trace the histories of two key centres and the communities in which they were and are embedded, their authors and illustrators, t ....The Illustrated Literature of Papunya and Strelley, 1979-1998. Literature Production Centres at Papunya and Strelley (WA) published hundreds of illustrated books during the 1970s, 1980s and 1990s. They tell stories of the first contact, the Dreaming, bush plants, animals and life on pastoral stations, missions, government settlements and communities. This project will trace the histories of two key centres and the communities in which they were and are embedded, their authors and illustrators, to build a dynamic picture of Indigenous Australia that contributes another dimension to the history of art and literature in Australia. It will produce scholarly papers, a monograph and an exhibition that brings this story to the Australian public.Read moreRead less
Investigating the molecular basis of T-cell receptor cross-reactivity. This project will explore the basis of unexpected immune reactions whereby the immune system mistakes one molecular structure for another, a phenomenon known as cross-reactivity. This project will examine how often this is due to molecular mimicry, potentially explaining why immune T cells sometimes react inappropriately to different agents.
Gold-based mitochondria targeted chemotherapeutics: mechanistic studies probing interactions with thiol and selenol containing proteins. Cancer affects one in four Australians and prostate cancer is the most commonly diagnosed and second leading cause of male cancer deaths, for which there is currently no effective treatment. Current chemotherapeutics must overcome drug resistance and lack of selectivity between tumour and normal cells. To circumvent these problems we are investigating gold-base ....Gold-based mitochondria targeted chemotherapeutics: mechanistic studies probing interactions with thiol and selenol containing proteins. Cancer affects one in four Australians and prostate cancer is the most commonly diagnosed and second leading cause of male cancer deaths, for which there is currently no effective treatment. Current chemotherapeutics must overcome drug resistance and lack of selectivity between tumour and normal cells. To circumvent these problems we are investigating gold-based compounds, which act by a novel mechanism. The research will lead to new strategies in the design of improved anticancer drugs, an important Australian research priority that will promote and maintain good health. Other benefits arise from training PhD students with interdisciplinary skills for Australian biotechnology industries.Read moreRead less
Understanding specificity and flexibility in coral symbioses. This project aims to understand why some corals can switch algal partners while others remain faithful to a single strain. This is important because corals depend on their symbiotic algal partners for survival and because some algae provide greater resilience to environmental stress than others. This project will greatly enhance our understanding of the molecular and physiological factors governing flexibility and specificity in coral ....Understanding specificity and flexibility in coral symbioses. This project aims to understand why some corals can switch algal partners while others remain faithful to a single strain. This is important because corals depend on their symbiotic algal partners for survival and because some algae provide greater resilience to environmental stress than others. This project will greatly enhance our understanding of the molecular and physiological factors governing flexibility and specificity in coral-algal symbioses. It will provide much-needed knowledge required to identify associations most appropriate for specific conditions, prioritise populations for conservation, and assess the feasibility of new approaches to managing and restoring coral reefs.
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Buried treasure: bioactive plant seed proteins evolving inside hosts. This project aims to examine how evolution in plants shortcuts the creation of new proteins by burying one within another. Scientists now realise that new genes and proteins appear frequently. A recent discovery in plant seeds involves DNA sequence insertions in a gene that makes two proteins instead of one. This project will reveal a new family of buried seed proteins, determine the rules for burying them and search plants fo ....Buried treasure: bioactive plant seed proteins evolving inside hosts. This project aims to examine how evolution in plants shortcuts the creation of new proteins by burying one within another. Scientists now realise that new genes and proteins appear frequently. A recent discovery in plant seeds involves DNA sequence insertions in a gene that makes two proteins instead of one. This project will reveal a new family of buried seed proteins, determine the rules for burying them and search plants for new examples. The first examples from plants create strongly bioactive products so the ability to dig for similar plant events will reveal new and bioactive natural products with biomedical and biotechnology applications.Read moreRead less