Mechanisms Of Premature Cranial Fusion: Role Of Retinol Binding Protein 4 In Osteogenesis And Suture Fusion
Funder
National Health and Medical Research Council
Funding Amount
$555,855.00
Summary
Craniosynostosis is a condition where the skull bones fuse prematurely, affecting skull shape, vision and cognition. It occurs in 1 in 2,500 births. The only treatment is surgery, which is life-threatening, costly and may need to be repeated. By studying how fusion happens in this project we may be able to devise therapies to minimize the risks and need for re-operation. Here, we hope to show that modification of a single substance in the skull of mouse models can prevent premature bone fusion.
Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internatio ....Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internationalisation strategies and consumption of Chinese culture on digital platforms in China, Australia, Hong Kong, Singapore and South Korea. It expects to understand the implications of China's digital ascendency and the lessons for Australia in the post-resources boom era.Read moreRead less
Promoting the making self in the creative micro-economy. The project aims to analyse a new workplace phenomenon: not simply the negotiation of work-life or public-private boundaries, but their deliberate collapse. Focussing on handmade creative micro-enterprise, it aims to identify the 'self-making' skills for success in the competitive 'long tail' craft marketplace. By examining the soft skills required to engage in online retail, the research aims to identify ways of improving the ability of c ....Promoting the making self in the creative micro-economy. The project aims to analyse a new workplace phenomenon: not simply the negotiation of work-life or public-private boundaries, but their deliberate collapse. Focussing on handmade creative micro-enterprise, it aims to identify the 'self-making' skills for success in the competitive 'long tail' craft marketplace. By examining the soft skills required to engage in online retail, the research aims to identify ways of improving the ability of creative Australians to run a micro-enterprise. It endeavours to advance the knowledge base of interdisciplinary scholarship on creative industries, cultural work, and on the impact of social media upon work/life relationships and personal privacy and identity construction.Read moreRead less
Reconfiguring intimate life: Gender and sexuality as sites of national redefinition in Australia since 1996. This project opens up current thinking about the nature of change in twenty-first century life in Australia by focusing on issues of gender and sexuality. It draws critical attention to a field of contest and re-negotiation of national identity and belonging, thus far not identified, that has far-reaching effects for the national fabric. It provides opportunities for thinking about sexual ....Reconfiguring intimate life: Gender and sexuality as sites of national redefinition in Australia since 1996. This project opens up current thinking about the nature of change in twenty-first century life in Australia by focusing on issues of gender and sexuality. It draws critical attention to a field of contest and re-negotiation of national identity and belonging, thus far not identified, that has far-reaching effects for the national fabric. It provides opportunities for thinking about sexual and reproductive relationships in ways that can be open to voices, stories and forms of belonging that signal a more generous, sustainable and healthy non-violent future.
The impact of the project will be on professional and scholarly training, teaching and research across a variety of disciplinary areas, as well as public debate. Read moreRead less
Understanding The Role Of The Atypical Cadherin Fat4 In Lymphatic Vascular Development
Funder
National Health and Medical Research Council
Funding Amount
$1,006,248.00
Summary
This application will define the role of a large cell adhesion molecule, FAT4, in lymphatic vascular development. By understanding how FAT4 functions in lymphatic vessels, we will gain insight to the mechanisms by which mutations in the gene that encodes this protein cause a human lymphoedema syndrome.
War, Computer Games and Contemporary Technoculture. This project examines computer games with a view to understanding the profound interrelationship of war and cultural developments that influences much of the innovation in computer gaming and simulation today. In the wake of the recent escalation of terrorism and state-supported counter-terrorism, war has become even more visible in media and audio-visual entertainment, making the question of the relation between war and mainstream culture one ....War, Computer Games and Contemporary Technoculture. This project examines computer games with a view to understanding the profound interrelationship of war and cultural developments that influences much of the innovation in computer gaming and simulation today. In the wake of the recent escalation of terrorism and state-supported counter-terrorism, war has become even more visible in media and audio-visual entertainment, making the question of the relation between war and mainstream culture one which poses itself with increasing urgency. This project's exploration of computer games is aimed at illuminating crucial features of this wider question of war's place in Australian contemporary culture, connected as it is to the global media context.Read moreRead less
Lost Generation: Women Writers and Postwar Modernity. This project will restore a 'lost generation' of Australian women writers to, and reconfigure the meanings of, literary culture in the post-World War 2 years. 1945-65 is a key period of Australian cultural development that is under-researched but over-laden with stereotypes, which still frame and restrict our understanding of it. A fuller and more complex picture of Australian modernity and modernism will be gained by placing women centrally ....Lost Generation: Women Writers and Postwar Modernity. This project will restore a 'lost generation' of Australian women writers to, and reconfigure the meanings of, literary culture in the post-World War 2 years. 1945-65 is a key period of Australian cultural development that is under-researched but over-laden with stereotypes, which still frame and restrict our understanding of it. A fuller and more complex picture of Australian modernity and modernism will be gained by placing women centrally in the picture, and by placing the Australian case within the international field. Such an enhanced understanding of the past is essential for us to have a more productive and harmonious future, and to play a significant role internationally.Read moreRead less
Use of mitochondrial electron transport chain mutants to evaluate how non-phosphorylating respiration influences plant metabolite profiles and stress tolerance. This project uses transgenic plant technology to elucidate how mitochondrial function impacts on the profile of metabolites in plant cell and tissues and whether altering these profiles influences a plant's ability tog row in harsh conditions. It will contribute to our fundamental knowledge of plant metabolism using a metabolomic anaylsi ....Use of mitochondrial electron transport chain mutants to evaluate how non-phosphorylating respiration influences plant metabolite profiles and stress tolerance. This project uses transgenic plant technology to elucidate how mitochondrial function impacts on the profile of metabolites in plant cell and tissues and whether altering these profiles influences a plant's ability tog row in harsh conditions. It will contribute to our fundamental knowledge of plant metabolism using a metabolomic anaylsis of plant stress response. This will be achieved using new high-throughput technologies, allowing reliable qualitative and quantitative analysis of large numbers of samples. This approach will compliment existing genomic and proteomic analyses of plants exposed to abiotic stress.Read moreRead less
Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
The migration of cancer cells (metastasis) is responsible for most cancer deaths. Central to this is dynamic organisation of the actin cytoskeleton _ an internal structure that provides cell shape and enables movement. We have identified a family of small molecules (called miR-200) that regulates this actin cytoskeleton through specifically downregulating various genes. We are investigating the nature of these genes and their role in cell motility _ an underlying pre-requisite of metastasis.