Mapping the family tree of carbon nanostructures: investigation of nanoscrolls and herringbones. New avenues of research in carbon science will be explored by defining a family tree of carbon nanostructures showing the relationship between forms. This project will investigate the properties of poorly unexplored relatives of the family; the results have the potential to impact on the choice of a material for a given application.
Exploiting shear to form new structures of carbon. This project aims to create new, technologically-interesting, materials by combining shear (sliding forces) with high pressure. The work will use both modelling and experiments to understand the pathways to form new materials such as a different form of diamond that is predicted to be harder than regular diamond. Such a material could be used in coatings for cutting tools or ultra-low-scratch surfaces. Expected outcomes include both an understan ....Exploiting shear to form new structures of carbon. This project aims to create new, technologically-interesting, materials by combining shear (sliding forces) with high pressure. The work will use both modelling and experiments to understand the pathways to form new materials such as a different form of diamond that is predicted to be harder than regular diamond. Such a material could be used in coatings for cutting tools or ultra-low-scratch surfaces. Expected outcomes include both an understanding of the importance of shear in the study of high-pressure science, and as a tool to manufacture new functional materials.Read moreRead less
Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first tra ....Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first transgenic marsupials. We will also investigate the ability of spermatozoa from species of increasing genetic distance to ferttilise marsupial eggs using intracytoplasmic sperm injection (ICSI).Read moreRead less
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposa ....An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposal aims to investigate, using X-ray crystallography as the primary research tool, co- receptors located on T-lymphocytes. This work will gain fundamental insights into co-receptor function.Read moreRead less
Is transport of miRNAs essential for plant development? This project will provide knowledge of how a new class of biologically active molecule (micro RNA) regulates expression of genes at sites in the plant that are critical for growth and development. MicroRNAs are believed to influence the size and shape of plants, how rapidly they grow and how well they produce and fill seeds. These molecules are part of a group of bioactive signals that move throughout the plant, functioning like hormones bu ....Is transport of miRNAs essential for plant development? This project will provide knowledge of how a new class of biologically active molecule (micro RNA) regulates expression of genes at sites in the plant that are critical for growth and development. MicroRNAs are believed to influence the size and shape of plants, how rapidly they grow and how well they produce and fill seeds. These molecules are part of a group of bioactive signals that move throughout the plant, functioning like hormones but directly influencing how well critical genes work. Their exploitation holds great promise for manipulating plant performance and enhancing crop yields. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100151
Funder
Australian Research Council
Funding Amount
$760,000.00
Summary
Probe and engineer interactions in atomic-scale devices with a LT STM. A low-temperature scanning tunnelling microscope: The project aims to establish a facility to exploit the spectroscopic and spatial resolution of an ultra-low temperature scanning tunnelling microscope in conjunction with atomically controlled dopant engineering. In a variety of experiments the research team will explore ultra-scaled transistors, quantum information science devices, and engineered quantum matter. Improving ou ....Probe and engineer interactions in atomic-scale devices with a LT STM. A low-temperature scanning tunnelling microscope: The project aims to establish a facility to exploit the spectroscopic and spatial resolution of an ultra-low temperature scanning tunnelling microscope in conjunction with atomically controlled dopant engineering. In a variety of experiments the research team will explore ultra-scaled transistors, quantum information science devices, and engineered quantum matter. Improving our ability to investigate semiconductor materials at the atomic scale impacts fields ranging from electronics, telecommunication, quantum information to renewable energy research and puts Australia at the forefront of the field of controlled atomic systems in semiconductors.Read moreRead less
CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research wil ....CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research will provide new data on the fundamental cellular and molecular events that are required to trigger the birth, differentiation and conditions for growth of new neurons in the adult nervous system. The generation of such insights will be critical for any translational research.
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ARC Centre of Excellence for Engineered Quantum Systems. The future of technology lies in controlling the quantum world. The ARC Centre of Excellence for Engineered Quantum Systems (EQuS) will deliver the building blocks of future quantum technologies and, critically, ensure Australian primacy in this endeavour. Three strategic research programs will target Quantum Measurement and Control; Synthetic Quantum Systems and Simulation; and Quantum-Enabled Sensors and Metrology. Within these programs, ....ARC Centre of Excellence for Engineered Quantum Systems. The future of technology lies in controlling the quantum world. The ARC Centre of Excellence for Engineered Quantum Systems (EQuS) will deliver the building blocks of future quantum technologies and, critically, ensure Australian primacy in this endeavour. Three strategic research programs will target Quantum Measurement and Control; Synthetic Quantum Systems and Simulation; and Quantum-Enabled Sensors and Metrology. Within these programs, our Centre will exploit the deepest principles and resources of quantum physics to solve specific problems in engineering, chemistry biology and medicine, stimulating the Australian scientific and engineering communities to exploit (and benefit from) transformative quantum devices.Read moreRead less
A Structural Investigation Into Events Within The Immunological Synapse. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide significant fundamental insight into the processes that control infection. Investigating processes central to immunity is important, as it will further our understanding of these critically-important events. Such knowledge will increase Australia's international research standing, as well as having the potential to generat ....A Structural Investigation Into Events Within The Immunological Synapse. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide significant fundamental insight into the processes that control infection. Investigating processes central to immunity is important, as it will further our understanding of these critically-important events. Such knowledge will increase Australia's international research standing, as well as having the potential to generate novel therapies, such as immunosuppressants.Read moreRead less