Economic complexity as a driver of innovation and smart specialisation. This project aims to determine how economic complexity can drive innovation and smart specialisation and how industry can be supported to transition to a more competitive economy. With the downturn of traditional manufacturing, innovation is crucial to create new industries and the jobs of the future. The expected outcomes of this project include high-value industry intelligence in support of product diversification. This sh ....Economic complexity as a driver of innovation and smart specialisation. This project aims to determine how economic complexity can drive innovation and smart specialisation and how industry can be supported to transition to a more competitive economy. With the downturn of traditional manufacturing, innovation is crucial to create new industries and the jobs of the future. The expected outcomes of this project include high-value industry intelligence in support of product diversification. This should provide significant benefits, such as increased international competitiveness, exports, revenue, and economic growth.
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Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and ....Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and the feminisation process, converted to practical ways to manipulate these important agronomic traits. This will derisk the industrial hemp industry, encouraging increased cultivation of a nutritionally and economically valuable crop in Australia and create valuable intellectual property applicable globally.Read moreRead less
Strategic responses of Australian family-owned businesses in the manufacturing sector to the pressures of globalisation. It is critical that Australian family owned manufacturing businesses respond in the most advantageous way to the pressures of globalisation. Possible strategic responses include selling out to larger companies that have a stronger strategic position, competing off-shore, or take a niche position in the value chain. This research will use a series of case studies to determine t ....Strategic responses of Australian family-owned businesses in the manufacturing sector to the pressures of globalisation. It is critical that Australian family owned manufacturing businesses respond in the most advantageous way to the pressures of globalisation. Possible strategic responses include selling out to larger companies that have a stronger strategic position, competing off-shore, or take a niche position in the value chain. This research will use a series of case studies to determine the contingent factors that best explain strategic response within the ownership and management structure of the family business, and track the impact of specific strategic choices. From this may flow some general principles of appropriate strategic responses given a range of circumstances.Read moreRead less
The contribution of beneficial arbuscular mycorrhizal (AM) fungi to sustainable tomato production in Australia. Formation of beneficial arbuscular mycorrhiza (AM) by processing tomatoes has been used as an indicator of 'healthy soil' in an environmental monitoring audit of the industry in southern Australia, but field occurrence of the AM fungi and their potential contribution to tomato nutrition and productivity are not well understood. We will determine the responsiveness of widely-grown tomat ....The contribution of beneficial arbuscular mycorrhizal (AM) fungi to sustainable tomato production in Australia. Formation of beneficial arbuscular mycorrhiza (AM) by processing tomatoes has been used as an indicator of 'healthy soil' in an environmental monitoring audit of the industry in southern Australia, but field occurrence of the AM fungi and their potential contribution to tomato nutrition and productivity are not well understood. We will determine the responsiveness of widely-grown tomato varieties to AM inoculation and relate colonisation in the field to farming practices. The results will determine the potential benefits of AM fungi to tomato crops, in the context of development of environmentally and economically sustainable practices both in Australia and overseas. Read moreRead less
Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level ....Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level of the individual to isolated enteroendocrine cells.Read moreRead less
Determining the regulation of vitamin D metabolism. The proposed project will lead to a better understanding of factors that influence the biological function of vitamin D. This will impact in several areas of human health and will provide new avenues for the development of preventative approaches and treatment of cancer. This project is based on the use of 'Frontier Technologies' that will be applied to elucidate basic biological questions.
The mechanisms and roles of receptor clustering in cell activation and wound healing by growth factors. Growth factors regulate cell proliferation, migration and differentation by interaction with receptors. Such receptors are usually localized at the cell surface, and require intracellular transduction systems to transmit the signal to the cell interior. We have recently shown the hormone-induced clustering of heterologous hormone receptors in cells, and that this occurs with the co-clustering ....The mechanisms and roles of receptor clustering in cell activation and wound healing by growth factors. Growth factors regulate cell proliferation, migration and differentation by interaction with receptors. Such receptors are usually localized at the cell surface, and require intracellular transduction systems to transmit the signal to the cell interior. We have recently shown the hormone-induced clustering of heterologous hormone receptors in cells, and that this occurs with the co-clustering of downstream signalling molecules at sites of engagement with the extracellular matrix. In addition, we have found that cells presented with an extracellular matrix respond better to subsequent growth factor stimulation. The project aims to determine the cellular mechanisms underlying receptor clustering and the basis of the receptor-extracellular matrix interaction. This will enhance our understanding of growth factor function in a number of conditions, including wound healing. We will extend our in vitro results to the animal model to define parameters for enhanced wound repair.Read moreRead less
Differentiation of Cord Blood Stem cells into Thymus (T) cells with regulatory phenotype and function. This project will develop technologies for a stem cell therapy platform based on cord blood stem cells, to enable treatment of autoimmune diseases or transplants. Building on the University of Adelaide's frontier demonstration of differentiation of regulatory Thymus (T) cells from cord blood stem cells, the project will develop techniques to expand the numbers of T cells generated. This has the ....Differentiation of Cord Blood Stem cells into Thymus (T) cells with regulatory phenotype and function. This project will develop technologies for a stem cell therapy platform based on cord blood stem cells, to enable treatment of autoimmune diseases or transplants. Building on the University of Adelaide's frontier demonstration of differentiation of regulatory Thymus (T) cells from cord blood stem cells, the project will develop techniques to expand the numbers of T cells generated. This has the potential to maintain Australia's lead in differentiation of cord blood stem cells and to provide a significant breakthrough in potential treatments of autoimmune diseases (e.g. type 1 diabetes) or transplantation. These diseases affect both a healthy start to life and healthy ageing, and an Australian invention to treat or cure them would have global impact.Read moreRead less
Characterisation of the oxygen-sensing asparaginyl hydroxylase, FIH-1, and hydroxylase-specific antagonists. This research will provide fundamental information on how cells and whole organisms can sense and respond accordingly to oxygen deficiency. This information is fundamental for our understanding of embryo development and adult life in different environments, and central to the diagnosis and treatment of diseases such as stroke, cardiovascular disease, and cancer. This research will contrib ....Characterisation of the oxygen-sensing asparaginyl hydroxylase, FIH-1, and hydroxylase-specific antagonists. This research will provide fundamental information on how cells and whole organisms can sense and respond accordingly to oxygen deficiency. This information is fundamental for our understanding of embryo development and adult life in different environments, and central to the diagnosis and treatment of diseases such as stroke, cardiovascular disease, and cancer. This research will contribute to our basic knowledge of these processes, provide invaluable information about the specific genes and proteins involved, and provide direct information about the therapeutic potential of specific drugs or inhibitors designed to target this oxygen response in human disease.Read moreRead less
Domestication of blue-banded bees for greenhouse pollination. The tomato industry is currently shifting towards production in greenhouses, which allows climate control and improved pest management. A lack of pollinators is an obstacle to this move. This project will establish protocols for large-scale use of native blue-banded bees as pollinators in greenhouses, especially for tomatoes. Pollination by native bees increases fruit weight by 15%, comparable to the effects of bumblebees used overs ....Domestication of blue-banded bees for greenhouse pollination. The tomato industry is currently shifting towards production in greenhouses, which allows climate control and improved pest management. A lack of pollinators is an obstacle to this move. This project will establish protocols for large-scale use of native blue-banded bees as pollinators in greenhouses, especially for tomatoes. Pollination by native bees increases fruit weight by 15%, comparable to the effects of bumblebees used overseas. Significant economic, environmental and health benefits are expected from this project. The outcome will satisfy an industry need and remove an environmental threat by finding indigenous substitutes for alien bumblebees.Read moreRead less