How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347607
Funder
Australian Research Council
Funding Amount
$306,000.00
Summary
FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged ex ....FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged expertise as well as priority within their respective institutions. In addition, it will facilitate wide-ranging collaborative arrangements to further develop and exploit this research area.Read moreRead less
Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered i ....Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered inside the cell as it tries to recover. It will give a much greater understanding of mitochondrial damage at the microscopic level, and has the potential to unlock new avenues of investigation into the causes of inflammatory and immune disorders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668241
Funder
Australian Research Council
Funding Amount
$824,610.00
Summary
A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflamma ....A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflammatory disease, brain damage and diabetes. Such genes may in turn constitute targets against which new therapies may be developed. This endeavour will contribute to national research priorities in both the health and scientific/technological development arenas.Read moreRead less
Special Research Initiatives - Grant ID: SR0354852
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia ....Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia's regions more competitive on world markets and more environmentally sustainable, and to help build stronger regional communities. The Network cuts across traditional discipline boundaries to find integrated solutions to the real problems confronting Australian regions.Read moreRead less
Next generation easy-clean lenses by robust liquid-repellent nanotextures. This project aims to produce better performing self-cleaning lenses, which are less likely to get dirty and are easy to clean. It will develop water and oil repellent coatings with superior optical transparency and mechanical, solvent and UV stability for both hard coated and anti-reflection coated optical lenses. Engineering of stable, ultra-liquid repellent nanomaterials on transparent surfaces will create a foundation ....Next generation easy-clean lenses by robust liquid-repellent nanotextures. This project aims to produce better performing self-cleaning lenses, which are less likely to get dirty and are easy to clean. It will develop water and oil repellent coatings with superior optical transparency and mechanical, solvent and UV stability for both hard coated and anti-reflection coated optical lenses. Engineering of stable, ultra-liquid repellent nanomaterials on transparent surfaces will create a foundation of knowledge for the industrial development of the future generation of easy care coatings, with vast application potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100129
Funder
Australian Research Council
Funding Amount
$425,200.00
Summary
Atomic layer nanofabrication system for multi-functional applications. This project aims to establish a multifunctional atomic layer nanofabrication facility in Sydney with the capacity to provide services nation-wide. The facility has powerful capabilities to produce mono-atom thin films, nanosize powders and two-dimensional nanostructures of a variety of materials, including elemental metals, metal oxides, metal nitrides, metal sulfides, metal-metal compounds, and polymers. This will significa ....Atomic layer nanofabrication system for multi-functional applications. This project aims to establish a multifunctional atomic layer nanofabrication facility in Sydney with the capacity to provide services nation-wide. The facility has powerful capabilities to produce mono-atom thin films, nanosize powders and two-dimensional nanostructures of a variety of materials, including elemental metals, metal oxides, metal nitrides, metal sulfides, metal-metal compounds, and polymers. This will significantly enhance Australian research and industrial activities in the areas of renewable energy production and storage, microelectronics, chemical and bio-sensors, protective coatings, flexible electronic devices, and catalysis.Read moreRead less
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. This Centre aims to explore the society wide transformations that will flow from optical frequency combs - thousands of highly pure light signals precisely spaced across the entire optical spectrum - by leveraging and building upon the latest breakthroughs in physics, materials science and nanofabrication. It expects to generate a wide new base of know ....ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. This Centre aims to explore the society wide transformations that will flow from optical frequency combs - thousands of highly pure light signals precisely spaced across the entire optical spectrum - by leveraging and building upon the latest breakthroughs in physics, materials science and nanofabrication. It expects to generate a wide new base of knowledge in fields as diverse as astronomy, spectroscopy, chemical sensors, and precision measurement. Expected outcomes include the capability to realise complete comb systems on a chip the size of a fingernail, tailored to specific applications, with significant benefits spanning from imaging live cells to autonomous vehicles, satellite communications, and the search for exoplanets.Read moreRead less