Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the da ....Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the dangerous resonances that can occur during rocket launch, using a combination of experimental, numerical, and theoretical techniques, in partnership with NASA, Stanford, and the CNRS.Read moreRead less
Positive Computing: The design of technologies that support psychological wellbeing. Designing future technology to foster psychological wellbeing has the potential to affect population-wide positive change. The design of software like apps or social media, can impact things like cyber-bullying, depression, or even foster resilience. This project aims to connect experts across multiple disciplines (psychology, technology and policy) to develop pioneering methods, knowledge, and strategies that w ....Positive Computing: The design of technologies that support psychological wellbeing. Designing future technology to foster psychological wellbeing has the potential to affect population-wide positive change. The design of software like apps or social media, can impact things like cyber-bullying, depression, or even foster resilience. This project aims to connect experts across multiple disciplines (psychology, technology and policy) to develop pioneering methods, knowledge, and strategies that will allow future technologies to play an active role in improving health, performance, and quality of life for all Australians, through research-based design for wellbeing. In doing so, Australia will lead the way on the technological front in a growing global initiative to improve the wellbeing of nations.Read moreRead less
Emerging technologies for enrichment in old age: A critical perspective. This project aims to generate knowledge about older adults' experiences with emerging technologies used for social and emotional enrichment. Technologies like virtual reality are said to offer social benefits for those in advanced old age, but we have limited knowledge about the issues that can impede older adults’ experiences with these technologies and even cause harm for vulnerable users. This project seeks to identify e ....Emerging technologies for enrichment in old age: A critical perspective. This project aims to generate knowledge about older adults' experiences with emerging technologies used for social and emotional enrichment. Technologies like virtual reality are said to offer social benefits for those in advanced old age, but we have limited knowledge about the issues that can impede older adults’ experiences with these technologies and even cause harm for vulnerable users. This project seeks to identify empirically informed strategies for good practice in the design and deployment of emerging technologies for enrichment in old age. This should inform the future ethical design and use of emerging technologies to benefit the social and emotional well-being of older Australians.Read moreRead less
Home helper robots: Understanding our future lives with human-like AI. This fellowship aims to understand and plan for the social effects of embedding ‘cute’ home helper robots into people’s everyday lives. The project is expected to generate new knowledge and resources to understand and respond to the emerging opportunities and risks associated with home helper robots, including their ability to support household tasks, and to provide child and aged care and companionship. Expected outcomes inc ....Home helper robots: Understanding our future lives with human-like AI. This fellowship aims to understand and plan for the social effects of embedding ‘cute’ home helper robots into people’s everyday lives. The project is expected to generate new knowledge and resources to understand and respond to the emerging opportunities and risks associated with home helper robots, including their ability to support household tasks, and to provide child and aged care and companionship. Expected outcomes include an improved understanding of anthropomorphised robots in everyday life and innovation in home helper robot theory and imaginaries. This should provide benefits such as informing robot design and policy to improve social outcomes, consumer protections and human-robot relationships.Read moreRead less
Apoptotic signalling in virally infected and normal cells. Viral diseases contribute substantially to mortality and morbidity, in Australia and internationally. Emerging viral diseases, including H5N1 avian influenza, have the potential to severely impact on human health and the global economy. Concerns also exist that viruses may be used as bioweapons. This project seeks to define the mechanisms by which cell death occurs and is regulated in healthy cells, and how this is altered in virally inf ....Apoptotic signalling in virally infected and normal cells. Viral diseases contribute substantially to mortality and morbidity, in Australia and internationally. Emerging viral diseases, including H5N1 avian influenza, have the potential to severely impact on human health and the global economy. Concerns also exist that viruses may be used as bioweapons. This project seeks to define the mechanisms by which cell death occurs and is regulated in healthy cells, and how this is altered in virally infected or oncogenically transformed cells. Outcomes of this work may contribute to development of novel anti-cancer and anti-viral therapies, diagnostic reagents and vaccines.Read moreRead less
Understanding the critical processes that control cell death and using this knowledge to kill cells that have evaded death. Cell death is essential for protecting the body against cancer, and defects in cell death pathways contribute to cancer progression. To design new and better cancer therapies we must understand the critical processes which control cell death, and develop effective ways to either reset, or bypass, defects in cell death pathways that contribute to cancer. The program as outl ....Understanding the critical processes that control cell death and using this knowledge to kill cells that have evaded death. Cell death is essential for protecting the body against cancer, and defects in cell death pathways contribute to cancer progression. To design new and better cancer therapies we must understand the critical processes which control cell death, and develop effective ways to either reset, or bypass, defects in cell death pathways that contribute to cancer. The program as outlined will elucidate the process of mitochondrial outer membrane permeabilization, a critical event in cell death by apoptosis, and determine how to kill cells in which this event is blocked.Read moreRead less
Role of Histone deacetylase 3 (HDAC3) in intestinal epithelial cell homeostasis and tumorigenesis. Colon cancer is the most common cancer that affects men and women in Australia. Annually, in Victoria alone, more than 3400 people are diagnosed with colon cancer. Colon cancer arises through the accumulation of mutations in key genes over time. Identification of cancer causing genes provides the basis for the design of new cancer therapies. We recently identified a gene called Histone deacetylase ....Role of Histone deacetylase 3 (HDAC3) in intestinal epithelial cell homeostasis and tumorigenesis. Colon cancer is the most common cancer that affects men and women in Australia. Annually, in Victoria alone, more than 3400 people are diagnosed with colon cancer. Colon cancer arises through the accumulation of mutations in key genes over time. Identification of cancer causing genes provides the basis for the design of new cancer therapies. We recently identified a gene called Histone deacetylase 3 (HDAC3) as potentially involved in promoting colon cancer. The current proposal will now extend and validate this finding in mice. Importantly, drugs which inhibit HDAC3 have recently been developed for the treatment of cutaneous T-cell lymphoma. Defining the role HDAC3 plays in colon cancer will justify testing these drugs in colon cancer patients.Read moreRead less
A pictorial communication framework for inclusion. A picture can tell a thousand words; many people with an intellectual disability can only communicate with pictures and are otherwise isolated. This project will research how computers can understand and facilitate a rich pictorial communication between people and person to machine, thereby supporting inclusion. This will be achieved by inclusively co-designing with people with ID and members of the community: a) an audio-visual accessible searc ....A pictorial communication framework for inclusion. A picture can tell a thousand words; many people with an intellectual disability can only communicate with pictures and are otherwise isolated. This project will research how computers can understand and facilitate a rich pictorial communication between people and person to machine, thereby supporting inclusion. This will be achieved by inclusively co-designing with people with ID and members of the community: a) an audio-visual accessible search tool, b) a pictorial communication device, and c) a visual inclusive social network. These applications will inform future innovations for everyone, and allow citizens with ID to access online information, participate in community activities and be included in the workplace.Read moreRead less
Nuclear and chromatin architecture in the replication stress response. DNA replication is an essential biological activity required for the transmittance of genomic material across cell divisions. If errors occur during DNA replication, this results in dangerous outcomes including mutation, genome instability, and cell death. Cells cope with challenges to DNA replication through a process called the replication stress response. This fellowship explores a newly discovered pathway in the replicati ....Nuclear and chromatin architecture in the replication stress response. DNA replication is an essential biological activity required for the transmittance of genomic material across cell divisions. If errors occur during DNA replication, this results in dangerous outcomes including mutation, genome instability, and cell death. Cells cope with challenges to DNA replication through a process called the replication stress response. This fellowship explores a newly discovered pathway in the replication stress response where changes to the architecture of a cell nucleus, and movement of the genomic material inside, promotes repair of genomic damage that occurs during replication. The result of this project will be an understanding of fundamental biological processes that protect human genomes.Read moreRead less
Ultimately Trusted Security through Human-Powered Cryptography. Cryptography offers wonderful tools for unbreakable data security, but only between computer nodes, leaving their human owners helpless. Encrypted tunnels terminate not at humans but at mobile phones and personal computers, exposing users' secrets to spyware from search-engine keyloggers to full-bore malware planted by crooks, hackers, and foreign spy agencies. This project aims to create a simple and strong cryptography, so that hu ....Ultimately Trusted Security through Human-Powered Cryptography. Cryptography offers wonderful tools for unbreakable data security, but only between computer nodes, leaving their human owners helpless. Encrypted tunnels terminate not at humans but at mobile phones and personal computers, exposing users' secrets to spyware from search-engine keyloggers to full-bore malware planted by crooks, hackers, and foreign spy agencies. This project aims to create a simple and strong cryptography, so that humans can, for the first time, take front seat in real security protocols. The technical challenge is to build public-key ciphers, operable manually from a mental key in seconds, and from there remake human-powered versions of many useful information security protocols.Read moreRead less