Operator Decision Modelling in Autonomous Systems. The incorporation of humans as decision-makers into a complex system comprising of many autonomous agents is becoming increasingly important in areas such as defence, search-and-rescue, special emergency services, bush-fire and ecology management. This project will address how human decisions are made in such systems through the formulation and demonstration of innovative algorithms which model the operator decision making process. Generating so ....Operator Decision Modelling in Autonomous Systems. The incorporation of humans as decision-makers into a complex system comprising of many autonomous agents is becoming increasingly important in areas such as defence, search-and-rescue, special emergency services, bush-fire and ecology management. This project will address how human decisions are made in such systems through the formulation and demonstration of innovative algorithms which model the operator decision making process. Generating solutions to this increasingly important area will provide Australia's industry and community services the necessary knowledge for deploying such systems and thus improving service effectiveness, as well as the implementation of autonomous systems into new areas and thus increasing economic growth.Read moreRead less
How, What and Who in Human Communication: Movement of Face and Voice. The aim of this project is to identify the essential characteristics of tone, affect, and identity from face and voice using a combination of signal processing, biological, and behavioural techniques in order to develop a comprehensive model of auditory-visual speech processing and communication. This research will significantly improve understanding of the basis of auditory-visual perception and production in tonal languages ....How, What and Who in Human Communication: Movement of Face and Voice. The aim of this project is to identify the essential characteristics of tone, affect, and identity from face and voice using a combination of signal processing, biological, and behavioural techniques in order to develop a comprehensive model of auditory-visual speech processing and communication. This research will significantly improve understanding of the basis of auditory-visual perception and production in tonal languages and in affective communication, facilitate links between neurophysiological processes and auditory-visual speech processing; and contribute to applications in automatic person recognition, automatic speech recognition, text-to-speech systems, and talking head aids for the hearing impaired.Read moreRead less
Ubiquinone in Giardia: Amitochondrial component in an amitochondriate parasite. Giardia intestinalis is a fascinating organism, it is one of the most primitive nucleated organisms known and is responsible for ~280 million infections annually. Ubiquinone is usually associated with mitochondrial function, however it has been found in Giardia, which lacks this organelle. Our initial studies show that in Giardia, ubiquinone plays essential roles in electron transport pathways associated with membr ....Ubiquinone in Giardia: Amitochondrial component in an amitochondriate parasite. Giardia intestinalis is a fascinating organism, it is one of the most primitive nucleated organisms known and is responsible for ~280 million infections annually. Ubiquinone is usually associated with mitochondrial function, however it has been found in Giardia, which lacks this organelle. Our initial studies show that in Giardia, ubiquinone plays essential roles in electron transport pathways associated with membrane energisation and oxidative stress management. Elucidation of these mechanisms will have a major impact on the understanding of Giardia and other anaerobic organisms as well as being of significant evolutionary and medical importance.
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Acoustic Filter Functions from Morphological Measurements. This project works toward enabling the broadcast of high-fidelity 3D audio. By developing an efficient technique for deriving personalised acoustic filter functions based on image data of the listener's head and ears, we hope to enable high-fidelity 3D audio decoding and rendering. Morphological parameterisation techniques and databases recently developed at the University of York will be combined with the statistical synthesis technique ....Acoustic Filter Functions from Morphological Measurements. This project works toward enabling the broadcast of high-fidelity 3D audio. By developing an efficient technique for deriving personalised acoustic filter functions based on image data of the listener's head and ears, we hope to enable high-fidelity 3D audio decoding and rendering. Morphological parameterisation techniques and databases recently developed at the University of York will be combined with the statistical synthesis techniques and databases developed at the University of Sydney to substantially reduce the development time required for either group alone. Psychoacoustic experiments carried out at the University of Sydney will demonstrate the fidelity of the delivered 3D audio.Read moreRead less
In situ measurements of the electrostatic properties inside photosynthetic reaction centres: correlation with the energy conversion function of the protein. The photochemical reaction centre is a key protein complex involved in energy conversion. It converts solar energy into chemical energy as a transmembrane charge separation. Coupling of electron and proton transfer is catalysed at the level of a ubiquinone cofactor. In order to understand how the redox properties of this cofactor are fine tu ....In situ measurements of the electrostatic properties inside photosynthetic reaction centres: correlation with the energy conversion function of the protein. The photochemical reaction centre is a key protein complex involved in energy conversion. It converts solar energy into chemical energy as a transmembrane charge separation. Coupling of electron and proton transfer is catalysed at the level of a ubiquinone cofactor. In order to understand how the redox properties of this cofactor are fine tuned by the protein environment, we plan to probe the ubiquinone site using a voltage-sensitive fluorescent dye. This exciting multidisciplinary project will contribute to the understanding of how protein matrices influence and govern the midpoint redox potential of their cofactors and the environments of theirRead moreRead less
An interactive drama engine in virtual reality. In computer games, the narrative is generally limited to a graph of possibilities predetermined by an author. In this project, our aim is to go beyond predetermined graphs and build an Interactive Drama Engine to provide the users of the system a fully immersive interactive dramatic experience in a virtual world. Integration of interactive narrative and virtual reality hardware and software is a novel approach to the current problems in digital med ....An interactive drama engine in virtual reality. In computer games, the narrative is generally limited to a graph of possibilities predetermined by an author. In this project, our aim is to go beyond predetermined graphs and build an Interactive Drama Engine to provide the users of the system a fully immersive interactive dramatic experience in a virtual world. Integration of interactive narrative and virtual reality hardware and software is a novel approach to the current problems in digital media. It is expected to lead to the development of new generation interactive films and computer games that benefit from the Interactive Drama engine in the context of narrative.Read moreRead less
Role of autophagy in degradation of endoplasmic reticulum (ER)-localised protein aggregates. This study will provide a new understanding of protein aggregate accumulation in the endoplasmic reticulum (ER), a phenomenon that occurs in aging cells and protein conformational diseases, and under stress conditions and during secretory protein overexpression. This information will inform strategies to prevent the onset of protein conformational diseases and help identify targets for pharmaceutical int ....Role of autophagy in degradation of endoplasmic reticulum (ER)-localised protein aggregates. This study will provide a new understanding of protein aggregate accumulation in the endoplasmic reticulum (ER), a phenomenon that occurs in aging cells and protein conformational diseases, and under stress conditions and during secretory protein overexpression. This information will inform strategies to prevent the onset of protein conformational diseases and help identify targets for pharmaceutical intervention. In addition, a powerful model system for studies of ER protein aggregation will be established, high-level training in biochemistry and morphometry will be provided, and an international collaboration of the highest calibre will be initiated.Read moreRead less
Heparan sulfate proteoglycan from smooth muscle cell basal lamina: It's role in cell signalling. Heart disease is the major killer of people in the Western world. central to this disease is the killing of heart muscle tissue to it being starved of oxygen via a "heart attack". One of the common treatments is coronary artery bypass surgery, however, the supply of vessels that can be used is limited. In order to provide an alternative supply of vessels, we are aiming to engineer blood vessels i ....Heparan sulfate proteoglycan from smooth muscle cell basal lamina: It's role in cell signalling. Heart disease is the major killer of people in the Western world. central to this disease is the killing of heart muscle tissue to it being starved of oxygen via a "heart attack". One of the common treatments is coronary artery bypass surgery, however, the supply of vessels that can be used is limited. In order to provide an alternative supply of vessels, we are aiming to engineer blood vessels in the laboratory. The major cell of the wall of arteries, the smooth muscle cell, is critical to normal functioning and integration of these transplanted arteries. To do this we will need to understand the cell signalling responses of these cells in relation to molecules in their surrounding environment.Read moreRead less
Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~ ....Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~30% of the population is infected with T. gondii and the occurrence of congenital toxoplasmosis is 0.2% of live births, which translates to roughly 500 cases/year. Our research will identify structural proteins in Toxoplasma cyst walls that will lead to the design of new strategies to control the diseases caused by these parasites.Read moreRead less
The effects of alpha-2-macroglobulin on amyloid formation and toxicity. The expected outcomes will provide major advances in understanding how the abundant human blood protein alpha-2-macroglobulin influences the formation of protein aggregates that underpin a number of serious diseases (e.g. Alzheimer's disease). The linkages involved are of the highest calibre and will give the Fellowship holder a unique opportunity for training in environments that are truly internationally leading-edge. Fur ....The effects of alpha-2-macroglobulin on amyloid formation and toxicity. The expected outcomes will provide major advances in understanding how the abundant human blood protein alpha-2-macroglobulin influences the formation of protein aggregates that underpin a number of serious diseases (e.g. Alzheimer's disease). The linkages involved are of the highest calibre and will give the Fellowship holder a unique opportunity for training in environments that are truly internationally leading-edge. Furthermore, the very high novelty and broad significance of this work indicate that it will produce high-impact publications which will tangibly assist Australia being recognized as a major contributor to international research outcomes of the highest quality.Read moreRead less