Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of th ....Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of the establishment of epigenetic state, combined with its heritability during mitosis, provides all the essential components for developmental noise. If our hypothesis proves correct, our work will have a major impact on the understanding of one of the most basic concepts in genetics.Read moreRead less
Identification of functionally important autophosphorylation site(s) on ataxia telangiectasia and Rad 3 - related (ATR) protein kinase. The integrity of our genetic material must be maintained so that it can be passed on from one generation to the next and also to minimize the risk of cancer and other pathologies in an individual. There are multiple proteins involved in protecting our DNA including several enzymes that detect and signal DNA damage to a series of pathways involved in halting the ....Identification of functionally important autophosphorylation site(s) on ataxia telangiectasia and Rad 3 - related (ATR) protein kinase. The integrity of our genetic material must be maintained so that it can be passed on from one generation to the next and also to minimize the risk of cancer and other pathologies in an individual. There are multiple proteins involved in protecting our DNA including several enzymes that detect and signal DNA damage to a series of pathways involved in halting the passage of cells through the cell cycle so that repair can occur. This project studies the mechanism of action of one of these enzymes which will be of benefit in designing new compounds to fight disease. Read moreRead less
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Sexual well-being and ageing: a study of older Australian women. This research addresses important issues of ageism and sexism that together affect older women's health and well-being. The findings will inform the link between aging, sexuality and more general dimensions of health and well-being and advance our understanding of issues central to policy and services for older Australians.
Working from home: New media technology, workplace culture and the changing nature of domesticity. New media technologies are often marketed as liberating people from the workplace, providing flexibility in meeting work obligations. Communication technologies in particular make working from home increasingly possible: laptops, mobile phones and PDAs make any space a potential site for paid labour. This research studies the effect of new media technologies on how work is performed, where and by w ....Working from home: New media technology, workplace culture and the changing nature of domesticity. New media technologies are often marketed as liberating people from the workplace, providing flexibility in meeting work obligations. Communication technologies in particular make working from home increasingly possible: laptops, mobile phones and PDAs make any space a potential site for paid labour. This research studies the effect of new media technologies on how work is performed, where and by whom, to gauge their impact on the community more broadly. It also asks whether these new relationships to work raise the prospect of changing traditional attitudes to the work performed in and outside the home by men and women.Read moreRead less
Understanding the potency and role of individual stem cells in the skin using Rainbow technology. To renew itself, the skin and its components rely on the activity of stem cells. This project will define more precisely the role of each individual stem cell by labelling them with a unique colour and following its fate. This project has the potential to change our current view on how the skin maintains and repairs itself.
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from ....The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from technological innovation and training local scientists in modern biology of environmental microorganisms. The Antarctic microorganisms provide unique compounds, enzymes and molecules for biotechnology and industry. Insight will be gained into the critical role that methanogens play in the global carbon cycle and global warming.Read moreRead less
Farmers of the Future: the Challenges of Feminised Agriculture in India. Neoliberal economic policies are fundamentally transforming the social landscapes of rural India, causing a deep agrarian crisis. The agrarian changes accentuate the unequal consequences for poor women and men in relation to: production (labour, tenure); livelihood and food security; access to and ownership of assets such as land and water and access to agricultural innovations and institutions. This multiscalar project inv ....Farmers of the Future: the Challenges of Feminised Agriculture in India. Neoliberal economic policies are fundamentally transforming the social landscapes of rural India, causing a deep agrarian crisis. The agrarian changes accentuate the unequal consequences for poor women and men in relation to: production (labour, tenure); livelihood and food security; access to and ownership of assets such as land and water and access to agricultural innovations and institutions. This multiscalar project investigates the causes and consequences of feminisation of agriculture in India’s transitioning economy in order to understand how gender roles and relations are being re-shaped in communities and households in diverse socioeconomic and cultural contexts and agro-ecological areas.Read moreRead less
Structured Writing Tasks: Examination of the process of change as indicated by cognitive-behavioural models of trauma. Research demonstrates that structured writing about past upsetting experiences is beneficial for physical and psychological health. The aim of this study is to identify the process of change responsible for these benefits. Three processes, based on trauma theory, have been identified (exposure, devaluation, and benefit-finding) and are manipulated within the writing paradigm. T ....Structured Writing Tasks: Examination of the process of change as indicated by cognitive-behavioural models of trauma. Research demonstrates that structured writing about past upsetting experiences is beneficial for physical and psychological health. The aim of this study is to identify the process of change responsible for these benefits. Three processes, based on trauma theory, have been identified (exposure, devaluation, and benefit-finding) and are manipulated within the writing paradigm. This study will test these processes in predicting future health benefits. It will increase the effectiveness of the writing paradigm for the general population, provide manualised variations of the writing paradigm based on trauma theory, examine patient-matching variables, and provide a base to conduct research in clinical populations.Read moreRead less