Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this ....Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this study will be a catalogue of functionally active circRNAs. Over the past decades, the wealth of knowledge on the function of linear mRNAs has had a significant impact on medicine and agriculture. Similarly understanding how circRNAs regulate cellular activities may have an analogous impact on humans.Read moreRead less
Differentiation of effector and tissue regulatory T cells . Regulatory T cells (Tregs) populate almost every organ of the body and play a central role in preventing inflammation and maintaining health. To exercise these functions, Tregs undergo a developmental program, the details of which are poorly known. This project will utilize newly developed biological tools and state-of-the-art technology to uncover the molecular mechanisms that govern Treg development and function. The project will gene ....Differentiation of effector and tissue regulatory T cells . Regulatory T cells (Tregs) populate almost every organ of the body and play a central role in preventing inflammation and maintaining health. To exercise these functions, Tregs undergo a developmental program, the details of which are poorly known. This project will utilize newly developed biological tools and state-of-the-art technology to uncover the molecular mechanisms that govern Treg development and function. The project will generate basic scientific knowledge and new intellectual property that will afford new opportunities for research and development. The outcomes of this project will help to devise strategies to treat diseases such as autoimmunity, cancer and metabolic syndrome, and will thus benefit veterinary and human health.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100584
Funder
Australian Research Council
Funding Amount
$424,636.00
Summary
DNA Replication Stress: Characterizing ground zero for genomic instability. The overarching goal of this research is to gain insights into key underlying molecular causes of, and responses to, DNA replication stress - one of the most fundamental biological processes enabling life as we know it. I will use advanced interdisciplinary imaging techniques to directly visualize DNA replication stress structures within cells in order to better understand how cells stop this stress from progressing into ....DNA Replication Stress: Characterizing ground zero for genomic instability. The overarching goal of this research is to gain insights into key underlying molecular causes of, and responses to, DNA replication stress - one of the most fundamental biological processes enabling life as we know it. I will use advanced interdisciplinary imaging techniques to directly visualize DNA replication stress structures within cells in order to better understand how cells stop this stress from progressing into DNA damage. Insights into these processes will have the potential to improve preventative and therapeutic approaches to diseases such as cancer and neurodegeneration. Read moreRead less
Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use ....Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use survey data that follows them over time to: 1) identify family structures that enhance or harm health and wellbeing, and; 2) track changes in health and wellbeing before, during and after family transitions (i.e. births, relationship changes). Anticipated results are better targeted policy interventions to reduce Indigenous health inequalities.Read moreRead less
Enhancing sleep and wellbeing in working families. This project aims to investigate the role of sleep on individuals’ health by measuring Australians' sleep patterns relative to work and family demands. This project expects to generate new knowledge in the sociology of sleep using innovative data collection bringing together cross-national, nationally representative, longitudinal and physiological data on Australians’ sleep patterns. Expected outcomes of this project are to identify the social a ....Enhancing sleep and wellbeing in working families. This project aims to investigate the role of sleep on individuals’ health by measuring Australians' sleep patterns relative to work and family demands. This project expects to generate new knowledge in the sociology of sleep using innovative data collection bringing together cross-national, nationally representative, longitudinal and physiological data on Australians’ sleep patterns. Expected outcomes of this project are to identify the social and biological determinants of sleep and their links with health, family and economic policy recommendations.Read moreRead less
Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the da ....Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the dangerous resonances that can occur during rocket launch, using a combination of experimental, numerical, and theoretical techniques, in partnership with NASA, Stanford, and the CNRS.Read moreRead less
The sociology of antibiotics and the antimicrobial resistance crisis. This project aims to investigate the sociological dimensions of antibiotics consumption by examining the views and experiences of clinicians, decision-makers, and members of the general population. The project expects to generate new knowledge about the social aspects of antibiotics use and consumer-provider interactions. Expected outcomes of this project include stronger consumer-provider collaborations about antibiotic use a ....The sociology of antibiotics and the antimicrobial resistance crisis. This project aims to investigate the sociological dimensions of antibiotics consumption by examining the views and experiences of clinicians, decision-makers, and members of the general population. The project expects to generate new knowledge about the social aspects of antibiotics use and consumer-provider interactions. Expected outcomes of this project include stronger consumer-provider collaborations about antibiotic use and a new evidence-base to guide policy decisions. This project should provide significant benefits for the national response to antimicrobial resistance, including enhanced public education and public policy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101618
Funder
Australian Research Council
Funding Amount
$397,241.00
Summary
Reproducibility and transparency in the synthesis of research findings. This project aims to evaluate the reproducibility and transparency of systematic reviews and meta-analyses of the effects of health, social, behavioural and educational interventions. The project expects to determine how reliable, trustworthy, and reusable syntheses of research findings are, and provide critical insight into the education and technical infrastructure needed to improve them. Expected outcomes of the project i ....Reproducibility and transparency in the synthesis of research findings. This project aims to evaluate the reproducibility and transparency of systematic reviews and meta-analyses of the effects of health, social, behavioural and educational interventions. The project expects to determine how reliable, trustworthy, and reusable syntheses of research findings are, and provide critical insight into the education and technical infrastructure needed to improve them. Expected outcomes of the project include new methods to enhance open and reproducible research practices in research synthesis, regardless of discipline. This should provide significant benefits beyond the DECRA, such as more credible evidence to inform government policies and professional society guideline recommendations.Read moreRead less
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
From mainstream to margins: The denormalisation of underage heavy drinking. This mixed-methods study aims to investigate changes in, and contemporary experiences of, heavy drinking for underage young people in Australia. The project expects to generate new knowledge on whether and how processes of ‘de-normalisation’ are shaping heavy drinking practices and experiences of social inclusion for underage young people. Expected outcomes of the project include the development of a contemporary theoret ....From mainstream to margins: The denormalisation of underage heavy drinking. This mixed-methods study aims to investigate changes in, and contemporary experiences of, heavy drinking for underage young people in Australia. The project expects to generate new knowledge on whether and how processes of ‘de-normalisation’ are shaping heavy drinking practices and experiences of social inclusion for underage young people. Expected outcomes of the project include the development of a contemporary theoretical model of underage drinking. This should provide significant benefits such as advancing understanding of the social and structural factors shaping heavy underage drinking practices. Findings can be used to inform policy directions aiming to holistically maximise health and social wellbeing for young people.Read moreRead less