Gating and permeation in ClC channels. Chloride ion channels are essential proteins in all living cells but, compared to other channels, little is known of their structure or how this defines and controls chloride transport. We will produce both normal and structurally modified (mutant and known to cause disease) chloride channels in cultured cells by genetic engineering so that we can analyse channel function using a combination of electrophysiological and chemical methods. We expect to learn ....Gating and permeation in ClC channels. Chloride ion channels are essential proteins in all living cells but, compared to other channels, little is known of their structure or how this defines and controls chloride transport. We will produce both normal and structurally modified (mutant and known to cause disease) chloride channels in cultured cells by genetic engineering so that we can analyse channel function using a combination of electrophysiological and chemical methods. We expect to learn which channel parts are fundamental and how subtle changes in structure can alter the opening and closing of these channels and the way that chloride passes through them.Read moreRead less
New High Temperature Proton Conducting Polymer Electrolyte For Sustainable Energy Conversion Applications. This project will bring the following significant benefit to the Australian community and economy:i)Energy and Environmental benefit: will provide the nation with an ultimate solution to zero emission vehicles and urban pollution; ii)Global Standing: will position Australia to become a global leader in sustainable energy conversion technology through the efficient fuel cell systems developm ....New High Temperature Proton Conducting Polymer Electrolyte For Sustainable Energy Conversion Applications. This project will bring the following significant benefit to the Australian community and economy:i)Energy and Environmental benefit: will provide the nation with an ultimate solution to zero emission vehicles and urban pollution; ii)Global Standing: will position Australia to become a global leader in sustainable energy conversion technology through the efficient fuel cell systems development;iii)Intellectual Property (IP): will deliver the nation a strong intellectual property (IP) position in the frontier technology, and; iv)Training: will train 2 high quality graduates in an emerging and multidisciplinary area of research with commercial turnover of more than $1000 million in Australia.Read moreRead less
New Insights into the Structure and Function of Pyruvate Carboxylase. Pyruvate carboxylase plays an essential roles in insulin secretion by pancreatic islets and in normal brain function, but excess expression of this enzyme in liver and adipose tissue is associated with diabetes and obesity.
Understanding the function of each structural feature in the reaction mechanism of an enzyme is essential to designing safe and effective pharmaceuticals that are required to modulate its activity.
Th ....New Insights into the Structure and Function of Pyruvate Carboxylase. Pyruvate carboxylase plays an essential roles in insulin secretion by pancreatic islets and in normal brain function, but excess expression of this enzyme in liver and adipose tissue is associated with diabetes and obesity.
Understanding the function of each structural feature in the reaction mechanism of an enzyme is essential to designing safe and effective pharmaceuticals that are required to modulate its activity.
This project, which will use cutting edge techniques in an experimental model, seeks to characterise this important enzyme's function so that better treatments can be developed in future for diabetes and obesity.
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Role of plant host factors in the replication and pathogenesis of Tomato leaf curl virus (TLCV). Geminivirus infection is an emerging problem in the Australian tomato growing industry which is currently worth ca.A$200m annually. Knowledge gained from this research will have direct benefit in safeguarding this industry by providing an insight into geminivirus replication and identifying molecular targets for virus control. More generally, the technology developed through this study will contribu ....Role of plant host factors in the replication and pathogenesis of Tomato leaf curl virus (TLCV). Geminivirus infection is an emerging problem in the Australian tomato growing industry which is currently worth ca.A$200m annually. Knowledge gained from this research will have direct benefit in safeguarding this industry by providing an insight into geminivirus replication and identifying molecular targets for virus control. More generally, the technology developed through this study will contribute to our basic understanding of virus replication in plants with a view to controlling virus diseases by direct molecular intervention with specifically engineered tools. We foresee potential industrial applications. Read moreRead less
Structural and Functional Aspects of the Allosteric Regulation of Pyruvate Carboxylase by Acyl-CoA Compounds. Pyruvate carboxylase occupies a central location in intermediary metabolism catalysing the formation of oxaloacetate, a key component of the Krebs' tricarboxylic acid cycle especially in its synthetic modes in gluconeogenesis, lipogenesis and in the synthesis of neurotransmitters.
This project aims: (i) To produce crystals of pyruvate carboxylase for determining its structure by X-ra ....Structural and Functional Aspects of the Allosteric Regulation of Pyruvate Carboxylase by Acyl-CoA Compounds. Pyruvate carboxylase occupies a central location in intermediary metabolism catalysing the formation of oxaloacetate, a key component of the Krebs' tricarboxylic acid cycle especially in its synthetic modes in gluconeogenesis, lipogenesis and in the synthesis of neurotransmitters.
This project aims: (i) To produce crystals of pyruvate carboxylase for determining its structure by X-ray diffraction; (ii) To use affinity-labelling to determine the amino acid residues in the binding site of the enzyme's allosteric activator, acetyl-CoA; (iii) To construct chimeric enzymes from different species to define regions of the enzyme which affect its responses to its important allosteric activator, acetyl-CoA.
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Investigating the coupled dependencies of soot in turbulent flames by advanced laser diagnostics and modelling. The community will benefit from the project by reduced air pollution and improved health and safety. Soot is a major air pollutant, adversely effecting public health, while also contributing directly to global warming. It also dominates heat transfer and influences the emissions of NOx and CO2. The project will significantly advance detailed understanding and modelling capability of fl ....Investigating the coupled dependencies of soot in turbulent flames by advanced laser diagnostics and modelling. The community will benefit from the project by reduced air pollution and improved health and safety. Soot is a major air pollutant, adversely effecting public health, while also contributing directly to global warming. It also dominates heat transfer and influences the emissions of NOx and CO2. The project will significantly advance detailed understanding and modelling capability of flames containing soot. Hence it will provide significantly improved capability to optimise these flames in applications spanning gas turbines, power generation, minerals processing and fires.Read moreRead less
Detailed understanding of the behaviour of soot in, and emission from, turbulent flames and fires. While combustion processes involving soot have been widely employed for many years, their great complexity puts them beyond present capacity to understand or model reliably. Within a flame, soot plays an important role in radiant heat transfer, and hence in energy efficiency. Beyond a flame, soot can either be emitted as an unwanted air pollutant or as a desirable source of nano-particles, dependin ....Detailed understanding of the behaviour of soot in, and emission from, turbulent flames and fires. While combustion processes involving soot have been widely employed for many years, their great complexity puts them beyond present capacity to understand or model reliably. Within a flame, soot plays an important role in radiant heat transfer, and hence in energy efficiency. Beyond a flame, soot can either be emitted as an unwanted air pollutant or as a desirable source of nano-particles, depending on the application. The benefits to society from improved understanding and predictive capability include reduced air pollution, improved health and safety, increased efficiency in the utilisation of both fossil and alternative fuels, the support of the rapidly growing sector employing carbon nano-particles and increased fire safety. Read moreRead less
Energy Dissipation and Nanoscale Processes at Moving Contact Lines. The dynamic process of liquids wetting and dewetting, as moving contact lines pass over solid surfaces is central to many industrial operations and natural phenomena. Contact line motion plays a key role in micro and nanofluidics, the foundation of an emergent technology called process intensification, where large industrial processes can be reduced to Lilliputian in size. Substantial energy reduction and other benefits are exp ....Energy Dissipation and Nanoscale Processes at Moving Contact Lines. The dynamic process of liquids wetting and dewetting, as moving contact lines pass over solid surfaces is central to many industrial operations and natural phenomena. Contact line motion plays a key role in micro and nanofluidics, the foundation of an emergent technology called process intensification, where large industrial processes can be reduced to Lilliputian in size. Substantial energy reduction and other benefits are expected from this project, including the transformation of coarse particle flotation. Young PhD scientists and engineers will be educated in a rich research environment, with strong international research collaboration in areas of national priority.Read moreRead less
Study of hydrocarbon flames under heat and gas recirculation conditions. This project aims to study gaseous flames under heat and gas recirculation conditions. This technology has been proven to reduce fuel consumption, improve thermal efficiency and substantially reduce nitric oxides emission. The effect of mixing, turbulence and temperature on the structure and stability of these flames will be investigated. The project combines experimental and computational research applied to a laboratory s ....Study of hydrocarbon flames under heat and gas recirculation conditions. This project aims to study gaseous flames under heat and gas recirculation conditions. This technology has been proven to reduce fuel consumption, improve thermal efficiency and substantially reduce nitric oxides emission. The effect of mixing, turbulence and temperature on the structure and stability of these flames will be investigated. The project combines experimental and computational research applied to a laboratory scale burner and a small scale furnace. The main objectives are to better understand the chemical pathways in low temperature hydrocarbon flames under heat and gas recirculation conditions and to understand the effect of mixing and turbulence on the flame structure and pollutants emission.Read moreRead less
Multifunctional Porous Nanospheres Engineered Composite Membranes for Hydrogen and Methanol Fuel Cells. Increasing concerns about greenhouse gas emissions and dwindling petroleum supplies have driven the development and commercialisation of fuel cells. The development of novel nanocomposite membranes will possibly lead to the materials breakthrough necessary for advancing both hydrogen and methanol fuel cell technologies, significantly benefiting Australian clean energy supplies and in particul ....Multifunctional Porous Nanospheres Engineered Composite Membranes for Hydrogen and Methanol Fuel Cells. Increasing concerns about greenhouse gas emissions and dwindling petroleum supplies have driven the development and commercialisation of fuel cells. The development of novel nanocomposite membranes will possibly lead to the materials breakthrough necessary for advancing both hydrogen and methanol fuel cell technologies, significantly benefiting Australian clean energy supplies and in particular transport vehicles and portable devices. The synthesis strategies generated will be applicable to creating other functional nanoporous or nanocomposite materials for wider application. This project will also enhance the international reputation and impact of Australian research in the internationally focused fields of nanomaterials and fuel cell technology.Read moreRead less