Structural elucidation and functional analysis of insulin-like growth factor binding protein-3 domains. Translating information from the human genome project into information about cell function is a major challenge in the post-genome era. The multifunctional insulin-like growth factor binding protein-3 (IGFBP-3), a member of a multigene superfamily, regulates cell growth and function through numerous signalling pathways. This project will provide structural information about IGFBP-3 as a protot ....Structural elucidation and functional analysis of insulin-like growth factor binding protein-3 domains. Translating information from the human genome project into information about cell function is a major challenge in the post-genome era. The multifunctional insulin-like growth factor binding protein-3 (IGFBP-3), a member of a multigene superfamily, regulates cell growth and function through numerous signalling pathways. This project will provide structural information about IGFBP-3 as a prototype for the superfamily, and using a combination of methodologies will unravel mechanisms of IGFBP-3 action. The project will advance understanding of IGFBP-3 and superfamily functions, and provide both benefits in international research leadership and economic and health benefits in animal and human growth and metabolism.Read moreRead less
The structure and function of dihydroorotase - an enzyme essential for pyrimidine biosynthesis. Malaria has recently re-emerged as one of the major life threatening diseases worldwide. With increasing travel and climate change, malaria is increasingly endangering Australians at home and abroad. Our work aims to provide the basis for the rational design of a new class of anti-malarial drugs by the systematic and thorough analysis of an essential enzyme in the malarial parasite.
Understanding and changing the mechanism of an enzyme: converting a peptidase to a phosphotriesterase. Enzymes have the ability to catalyse biological reactions rapidly as a consequence of their unique three-dimensional structures. We seek to define the structures of a family of metalloenzymes that are required in most living organisms to activate hormones, degrade unwanted proteins or recycle the protein building blocks for further synthesis. We shall use this information to enhance a second ....Understanding and changing the mechanism of an enzyme: converting a peptidase to a phosphotriesterase. Enzymes have the ability to catalyse biological reactions rapidly as a consequence of their unique three-dimensional structures. We seek to define the structures of a family of metalloenzymes that are required in most living organisms to activate hormones, degrade unwanted proteins or recycle the protein building blocks for further synthesis. We shall use this information to enhance a second function of these enzymes, namely their ability to break down organophosphorus-containing insecticides and nerve agents. Ultimately, the structural information resulting from this project may be used in drug design to regulate blood pressure and in engineering proteins for bioremediation.Read moreRead less
Development of novel high efficiency thermoelectric oxides for high temperature power generation. Thermoelectric materials are considered as a key factor in clean energy production, based on the conversion of waste heat emitted by power plants and automobiles to electricity. A series of novel high performance Co-based oxide thermoelectric materials will be developed by this project using nanotechnology and advanced material processing techniques. Significant improvement of the heat-to-electricit ....Development of novel high efficiency thermoelectric oxides for high temperature power generation. Thermoelectric materials are considered as a key factor in clean energy production, based on the conversion of waste heat emitted by power plants and automobiles to electricity. A series of novel high performance Co-based oxide thermoelectric materials will be developed by this project using nanotechnology and advanced material processing techniques. Significant improvement of the heat-to-electricity conversion factor is expected to result from the proposed program. The novel thermoelectric oxides with high thermoelectric performance will be practically used for high temperature power generation. This will provide a long-term solution to the global warming threat through decreasing amounts of waste heat presently generated. Read moreRead less
Regulation of mammalian heart development by transcription factors FHL2, GATA-4 & FOG-2. FHL2 is involved in many biological processes including intracellular signaling and gene transcription. GATA and FOG proteins are critical for the development of diverse tissues, including the heart. Knowledge gained in this project will advance our understanding of many cellular processes, including heart development, and will contribute to our knowledge in Biology, Zoology and Veterinary Science. More spe ....Regulation of mammalian heart development by transcription factors FHL2, GATA-4 & FOG-2. FHL2 is involved in many biological processes including intracellular signaling and gene transcription. GATA and FOG proteins are critical for the development of diverse tissues, including the heart. Knowledge gained in this project will advance our understanding of many cellular processes, including heart development, and will contribute to our knowledge in Biology, Zoology and Veterinary Science. More specifically, it will contribute to Stem Cell research, a 'hot' area in the biotechnology industry, particularly towards building a strong base of expertise, skills and technological capability in this new field, and may even lead to the development of a commercial product e.g. a heart muscle cell-coated biomaterial to aid failing heart.Read moreRead less
How does clusterin protect cells from stresses? We recently discovered that clusterin: (i) is the only known secreted (ie extracellular) mammalian chaperone and (ii) can protect proteins and cells from stresses.These breakthrough advances provide the first unifying biological function for this protein - in whole organisms, clusterine is likely to protect tissues and organs form biologyical stresses. The work proposed will provide quantum advances in our understanding of the molecular basis by wh ....How does clusterin protect cells from stresses? We recently discovered that clusterin: (i) is the only known secreted (ie extracellular) mammalian chaperone and (ii) can protect proteins and cells from stresses.These breakthrough advances provide the first unifying biological function for this protein - in whole organisms, clusterine is likely to protect tissues and organs form biologyical stresses. The work proposed will provide quantum advances in our understanding of the molecular basis by which clusterin effects its protective actions. We expect to demonstrate that clusterin protects cells form stresses by exerting its chaperone action at or near the cell surface and to identify specific regions and structural features of the clusterine molecule important in its chaperone action.Read moreRead less
Increase in Photocatalytic Activity of TiO2 through Intervalence Charge Transfer. Titanium dioxide (TiO2) has many proposed and realised applications in energy and the environment. The main problem that has hindered development and commercialisation of devices using TiO2 is its low photocatalytic activity, which results from its poor absorption of visible and infrared light. Most researchers modify the properties of TiO2 by conventional electrochemical methods to improve its performance but the ....Increase in Photocatalytic Activity of TiO2 through Intervalence Charge Transfer. Titanium dioxide (TiO2) has many proposed and realised applications in energy and the environment. The main problem that has hindered development and commercialisation of devices using TiO2 is its low photocatalytic activity, which results from its poor absorption of visible and infrared light. Most researchers modify the properties of TiO2 by conventional electrochemical methods to improve its performance but these attempts have been of limited success. The present research involves a completely new approach to the problem, which is based on the method used in the heat treatment of sapphire to improve its colour. This approach uses a phenomenon involving the modification of the optical properties to improve its absorption of light.Read moreRead less
Combined Particle Image Velocimetry (PIV) and CFD modelling to study particle deposition in conduits. System geometry greatly influences flow hydrodynamics and hence the transport of colloidal particles and ionic species from the bulk to the surfaces that result in formation of unwanted deposit matter on the surface. The formation of unwanted deposits has significant environmental and economic penalties. This project uses a new approach that is combining the CFD modelling and experimentation inc ....Combined Particle Image Velocimetry (PIV) and CFD modelling to study particle deposition in conduits. System geometry greatly influences flow hydrodynamics and hence the transport of colloidal particles and ionic species from the bulk to the surfaces that result in formation of unwanted deposit matter on the surface. The formation of unwanted deposits has significant environmental and economic penalties. This project uses a new approach that is combining the CFD modelling and experimentation including flow visualization by PIV to systematically investigate the effect of channel geometry and flow on deposit formation. The outcomes of the project will result in a better understanding and formulating of the effect of geometry on deposition of colloidal particles and ionic species on the surfaces. The results contribute not only towards the mitigation processes for unwanted deposition; it also advances the knowledge in coating applications.Read moreRead less
Novel 3D Carbon Architectures for Fuel Cell Applications. The implementation of clean energy technologies has clear economic, environmental and social benefits for Australia, its industries and population. This project has the potential to make a significant impact on fuel cell research as an alternative means of energy production. We aim to remove some of the technical and economic barriers through product and process innovation at the nanoscale. Building on a strong track record in advanced ma ....Novel 3D Carbon Architectures for Fuel Cell Applications. The implementation of clean energy technologies has clear economic, environmental and social benefits for Australia, its industries and population. This project has the potential to make a significant impact on fuel cell research as an alternative means of energy production. We aim to remove some of the technical and economic barriers through product and process innovation at the nanoscale. Building on a strong track record in advanced materials research, this project investigates the integration of novel carbon nanostructures with extraordinary properties to produce high performance electrodes, that should lead to significant improvement in fuel cell performance.Read moreRead less
New concepts with multidisciplinary approach: novel functionalised nanostructures for hydrogen storage. This project addresses National Research Priorities in the areas of breakthrough science, frontier technologies and advanced materials. Developing new methodologies to fabricate novel functionalised nanostructured materials with tailored properties has great potential in areas including energy storage, novel catalysts, novel sensors, micro/nano-electronics, etc. This project will enhance the i ....New concepts with multidisciplinary approach: novel functionalised nanostructures for hydrogen storage. This project addresses National Research Priorities in the areas of breakthrough science, frontier technologies and advanced materials. Developing new methodologies to fabricate novel functionalised nanostructured materials with tailored properties has great potential in areas including energy storage, novel catalysts, novel sensors, micro/nano-electronics, etc. This project will enhance the international reputation and impact of Australian research in the internationally focused fields of nanotechnology and hydrogen energy technology. Applying innovative nanotechnology to the area of hydrogen energy will add to Australia's export potential and reduce Australia's reliance on foreign fuel sources.
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