Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100015
Funder
Australian Research Council
Funding Amount
$523,899.00
Summary
Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The pro ....Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The proposed facility features high-quality measurements in an unmatched spatial and temporal range, allowing studying physical and chemical phenomena that are difficult to detect using conventional methods. The proposed integrated system will be the first of its kind in Australia. Read moreRead less
Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income priva ....Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income private, public and community rental housing. Adoption of the Project’s outcomes are expected to benefit low-income renters, assist electricity retailers to maintain and extend their customer base, and provide commercial incentives for the many stakeholders providing rental housing and residential solar and battery systems.Read moreRead less
Low cost aqueous rechargeable zinc batteries for grid-scale energy storage. This project aims to advance energy storage technology by developing high energy aqueous rechargeable zinc batteries, which are the most promising choice for large-scale electrical energy storage, in particular for smart electric grids, owing to their low cost, high safety, and eco-friendly features. The success of this project will advance our fundamental understanding of aqueous rechargeable batteries, provide techniqu ....Low cost aqueous rechargeable zinc batteries for grid-scale energy storage. This project aims to advance energy storage technology by developing high energy aqueous rechargeable zinc batteries, which are the most promising choice for large-scale electrical energy storage, in particular for smart electric grids, owing to their low cost, high safety, and eco-friendly features. The success of this project will advance our fundamental understanding of aqueous rechargeable batteries, provide techniques for the development of a low-cost, high energy, and long life system for renewable energy storage, and benefit Australia's environment, economy, and sustainability.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered i ....Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered inside the cell as it tries to recover. It will give a much greater understanding of mitochondrial damage at the microscopic level, and has the potential to unlock new avenues of investigation into the causes of inflammatory and immune disorders.Read moreRead less
Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this ....Androgen receptor: A master regulator of lipid metabolism. This project aims to understand how male sex hormones, or androgens, affect the amount and metabolism of fats in normal body tissues. By integrating our multi-disciplinary expertise in androgen action, molecular biology, metabolism and bioinformatics with novel techniques and instrumentation, this collaboration expects to generate the first detailed picture of how fat metabolism is controlled by androgens in humans, and how closely this relates to mice. Expected outcomes and benefits will be a new understanding of which aspects of fat metabolism are most influenced by androgens, and an ability to anticipate potential metabolic impacts of natural or pharmacological fluctuations in androgen levels in humans, laboratory animals and livestock.Read moreRead less
ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. This Centre aims to advance carbon dioxide electrochemistry innovations to enable the conversion of carbon dioxide into valuable products and transition Australia to a carbon-neutral economy. This Centre expects to generate new knowledge using experimental and computational approaches to develop systems-level understanding to fu ....ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. ARC Centre of Excellence for Green Electrochemical Transformation of Carbon Dioxide. This Centre aims to advance carbon dioxide electrochemistry innovations to enable the conversion of carbon dioxide into valuable products and transition Australia to a carbon-neutral economy. This Centre expects to generate new knowledge using experimental and computational approaches to develop systems-level understanding to furnish industry-ready carbon dioxide utilisation technologies. Expected outcomes include enhanced capacity through collaborations establishing the Centre as an international hub for research, training, technology translation and strategic advice for stakeholders and policymakers. This should accelerate Australia’s progress towards net zero emissions targets and grow a sustainable economy and create future jobs.Read moreRead less
How do protein quality control mechanisms maintain neuronal ageing? This project aims to interrogate how mechanisms of protein quality control act in the brain - an organ that is particularly vulnerable to a high load of misfolded protein - to maintain normal physiology during ageing. This project expects to make advances in cellular biochemistry and neuroscience, using an innovative proximity labelling approach to identify quality control regulators in neurons that specifically engage with misf ....How do protein quality control mechanisms maintain neuronal ageing? This project aims to interrogate how mechanisms of protein quality control act in the brain - an organ that is particularly vulnerable to a high load of misfolded protein - to maintain normal physiology during ageing. This project expects to make advances in cellular biochemistry and neuroscience, using an innovative proximity labelling approach to identify quality control regulators in neurons that specifically engage with misfolded proteins during ageing, within the nervous system of a living animal. Expected outcomes of this project will generate new knowledge of brain physiology and ageing relevant to all animals. This should provide significant benefits, such as a greater understanding of long-term brain functions including memory.Read moreRead less
Targeting chloroplasts to enhance crop salt tolerance. Yield losses in crop plants due to increasingly saline soils are linked to the effects of salt on chloroplasts. By comparing chloroplast water- and salt-transport mechanisms of closely related salt-loving and salt-sensitive plants, this Fellowships aims to discover how chloroplasts maintain function in saline conditions. Novel biophysics and molecular techniques will be used to characterise transporters in model plants, and proof-of-concept ....Targeting chloroplasts to enhance crop salt tolerance. Yield losses in crop plants due to increasingly saline soils are linked to the effects of salt on chloroplasts. By comparing chloroplast water- and salt-transport mechanisms of closely related salt-loving and salt-sensitive plants, this Fellowships aims to discover how chloroplasts maintain function in saline conditions. Novel biophysics and molecular techniques will be used to characterise transporters in model plants, and proof-of-concept complementation experiments aim to confer salt tolerance on sensitive plants. These fundamental insights are likely to lead to rapid, step-change improvements in salt tolerance, especially in agriculturally relevant crops, to benefit Australia’s agri-industry and ensure food security in the future.Read moreRead less
Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations t ....Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations that optimise plant yield and fitness will be defined and explored in other, more complex, cereals such as wheat. Expected outcomes will be fundamental breakthroughs in understanding how plants respond to, and buffer, the effects of heat to lead to translational breeding strategies that bolster grain yield.Read moreRead less