Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100015
Funder
Australian Research Council
Funding Amount
$523,899.00
Summary
Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The pro ....Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The proposed facility features high-quality measurements in an unmatched spatial and temporal range, allowing studying physical and chemical phenomena that are difficult to detect using conventional methods. The proposed integrated system will be the first of its kind in Australia. Read moreRead less
Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income priva ....Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income private, public and community rental housing. Adoption of the Project’s outcomes are expected to benefit low-income renters, assist electricity retailers to maintain and extend their customer base, and provide commercial incentives for the many stakeholders providing rental housing and residential solar and battery systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100661
Funder
Australian Research Council
Funding Amount
$439,237.00
Summary
Designing Multi-Metallic Compound Electrocatalysts for Chemicals Production. This project aims to design highly active, specifically selective, satisfactorily stable catalysts based on advanced ionic compound materials for carbon dioxide (CO2) electroreduction. Innovations are expected in the multi-metallic composition to ensure catalytic performance while maintain stability under electrochemical conditions. With assistance of artificial-intelligence approaches, numerous atomic-scale modelling, ....Designing Multi-Metallic Compound Electrocatalysts for Chemicals Production. This project aims to design highly active, specifically selective, satisfactorily stable catalysts based on advanced ionic compound materials for carbon dioxide (CO2) electroreduction. Innovations are expected in the multi-metallic composition to ensure catalytic performance while maintain stability under electrochemical conditions. With assistance of artificial-intelligence approaches, numerous atomic-scale modelling, speed-up theoretical simulation and rational screening can be achieved. Expected outcomes include providing guidance in elemental composition ratio and suitable reaction conditions for experiments. Benefits include reduced CO2 to fight climate change and increased green-fuel production for sustainable growth of Australia.Read moreRead less
Low cost aqueous rechargeable zinc batteries for grid-scale energy storage. This project aims to advance energy storage technology by developing high energy aqueous rechargeable zinc batteries, which are the most promising choice for large-scale electrical energy storage, in particular for smart electric grids, owing to their low cost, high safety, and eco-friendly features. The success of this project will advance our fundamental understanding of aqueous rechargeable batteries, provide techniqu ....Low cost aqueous rechargeable zinc batteries for grid-scale energy storage. This project aims to advance energy storage technology by developing high energy aqueous rechargeable zinc batteries, which are the most promising choice for large-scale electrical energy storage, in particular for smart electric grids, owing to their low cost, high safety, and eco-friendly features. The success of this project will advance our fundamental understanding of aqueous rechargeable batteries, provide techniques for the development of a low-cost, high energy, and long life system for renewable energy storage, and benefit Australia's environment, economy, and sustainability.Read moreRead less
Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is ....Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is to define the critical role of a novel enzyme called UGT8 in controlling intestinal stem cell response to bile acids; this is achieved by modulating UGT8 activity in intestinal stem cell models and determining the effects on stem cell function and the key signalling pathways that control intestinal homeostasis and renewal.Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100604
Funder
Australian Research Council
Funding Amount
$436,600.00
Summary
How do cells sense and react to mechanical forces? There is accumulating evidence that mechanical forces exerted on tissues and cells strongly influences their behaviour. My research aims to understand how cells sense and respond to forces experienced throughout life. Using a combination of three-dimensional cell and tissue culture methods, I will investigate how compressive forces change the biochemistry of cells and their functionality. This work is aimed at generating fundamental knowledge to ....How do cells sense and react to mechanical forces? There is accumulating evidence that mechanical forces exerted on tissues and cells strongly influences their behaviour. My research aims to understand how cells sense and respond to forces experienced throughout life. Using a combination of three-dimensional cell and tissue culture methods, I will investigate how compressive forces change the biochemistry of cells and their functionality. This work is aimed at generating fundamental knowledge to improve our comprehension of how cells respond to force. The expected outcome is a greater understanding of mechanical and biochemical relationships between cells and the environment, to inform fields of tissue engineering of culture scaffolds to better mimic natural cell-tissue settings.Read moreRead less
New mechanisms regulating the biogenesis of extracellular vesicles. Extracellular vesicles are small packages that contain active components derived from the cell of origin. These vesicles, released by most cell types, are critical for communication between cells. However, the processes of their formation and release remain poorly understood. This project aims to explore how ubiquitination, a type of protein modification system, controls the production of extracellular vesicles. Using a strong c ....New mechanisms regulating the biogenesis of extracellular vesicles. Extracellular vesicles are small packages that contain active components derived from the cell of origin. These vesicles, released by most cell types, are critical for communication between cells. However, the processes of their formation and release remain poorly understood. This project aims to explore how ubiquitination, a type of protein modification system, controls the production of extracellular vesicles. Using a strong collaborative team and highly innovative approaches, the project will generate new knowledge to inform how cells communicate. Expected outcomes include knowledge of broad significance to cell biology, that can be leveraged to develop extracellular vesicles as tools for various biotechnology applications in the future.Read moreRead less
Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered i ....Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered inside the cell as it tries to recover. It will give a much greater understanding of mitochondrial damage at the microscopic level, and has the potential to unlock new avenues of investigation into the causes of inflammatory and immune disorders.Read moreRead less