Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the p ....Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the period, as well as a greater appreciation of the gender-inclusivity of Stoic philosophy. This should provide significant benefits, such as the development of Stoic therapeutic techniques informed by women’s experiences, and the promotion of gender equality through the recognition of women’s intellectual history.Read moreRead less
Understanding selfie-editing apps in youth visual digital cultures. This project aims to investigate how young people navigate identity and body image concerns online through new digital editing tools provided by selfie-editing apps. The project expects to generate new knowledge about the literacies young people use in reading, evaluating and editing images of themselves, and the role of digital technologies in forming young people’s embodied identities, using an innovative participatory methodo ....Understanding selfie-editing apps in youth visual digital cultures. This project aims to investigate how young people navigate identity and body image concerns online through new digital editing tools provided by selfie-editing apps. The project expects to generate new knowledge about the literacies young people use in reading, evaluating and editing images of themselves, and the role of digital technologies in forming young people’s embodied identities, using an innovative participatory methodology. Expected outcomes include a new evidence base and youth-centred conceptual framework on the connections between youth selfie-editing, body image, and wellbeing. This should provide significant benefits in helping young people to better navigate body image and wellbeing in online cultures.Read moreRead less
Understanding the long term impact of childhood emotional abuse. This project will generate new knowledge about the social dimensions of childhood emotional abuse. Experiences of childhood emotional abuse are extremely common, with many affected individuals going on to face long term health problems, social marginalisation, intergenerational family violence and re-victimisation. This project will investigate how different social contexts influence childhood emotional abuse itself and the interco ....Understanding the long term impact of childhood emotional abuse. This project will generate new knowledge about the social dimensions of childhood emotional abuse. Experiences of childhood emotional abuse are extremely common, with many affected individuals going on to face long term health problems, social marginalisation, intergenerational family violence and re-victimisation. This project will investigate how different social contexts influence childhood emotional abuse itself and the interconnected problems flowing from it that often persist over the life course. The findings of this project will increase the evidence base and inform the future development of policy and practice that aims to prevent the intergenerational transmission of violence and abuse, and improve health and social outcomes. Read moreRead less
The philosophical influences on anthropology. This project aims to undertake a comprehensive account of Kant’s impact on the early history of anthropology, offering a new framework for understanding philosophy’s role as a cultural force in society. The project will investigate the importance of Kant’s twin narratives of progressive human development and racial difference for understanding the course taken by anthropology when determining government policies regarding race relations. The benefit ....The philosophical influences on anthropology. This project aims to undertake a comprehensive account of Kant’s impact on the early history of anthropology, offering a new framework for understanding philosophy’s role as a cultural force in society. The project will investigate the importance of Kant’s twin narratives of progressive human development and racial difference for understanding the course taken by anthropology when determining government policies regarding race relations. The benefit of this reconstruction will be the identification of contemporary examples of Kant’s continued legacy, especially in the context of legacies of racial bias, and to the nature of claimed racial and ethnic identities.Read moreRead less
The experimental self in early modern philosophy. This project aims to analyse an unrecognised connection between the emergence of experience-grounded theories of the self and the rise of early modern experimentalism. These are two developments in early modern philosophy which paved the way for today’s conception of science. By studying the influence of Cartesian physiology on early modern accounts of embodied cognition, the project seeks to correct some of the misconceptions of the period. The ....The experimental self in early modern philosophy. This project aims to analyse an unrecognised connection between the emergence of experience-grounded theories of the self and the rise of early modern experimentalism. These are two developments in early modern philosophy which paved the way for today’s conception of science. By studying the influence of Cartesian physiology on early modern accounts of embodied cognition, the project seeks to correct some of the misconceptions of the period. The project aims to clarify the role of human agency in advancement of knowledge, and develop a conceptual framework that allows a more nuanced and complex understanding of the relationship between the humanities and sciences.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Women marginalised by mental health, disability or refugee status. Women impacted by mental illness, disability or refugee status are among society’s most vulnerable and disenfranchised groups. Such women can experience significant social exclusion, marginalisation and stigma, associated with reduced help seeking, deprivation of dignity and human rights, and threats to health, well-being and quality of life. However, many women demonstrate resilience and agency, associated with positive health o ....Women marginalised by mental health, disability or refugee status. Women impacted by mental illness, disability or refugee status are among society’s most vulnerable and disenfranchised groups. Such women can experience significant social exclusion, marginalisation and stigma, associated with reduced help seeking, deprivation of dignity and human rights, and threats to health, well-being and quality of life. However, many women demonstrate resilience and agency, associated with positive health outcomes. This research will identify how women negotiate stigma and potential marginalisation, to inform health policy, and target interventions for vulnerable women, generating much-needed insight on women’s embodiment of stigma, and strategies used to cope with, negotiate and resist their stigmatised identities. Read moreRead less
Sustainable mobility: city-wide exposure modelling to advance bicycling. This project aims to develop a world-leading platform for city-wide modelling of cycling exposure. This project will provide unparalleled insights into cycling exposure by combining multiple cycling data sources through the use of advanced spatial statistical and machine learning techniques. The expected outcomes of this project are a novel inventory of cycling infrastructure, a cycling route choice modelling system and rob ....Sustainable mobility: city-wide exposure modelling to advance bicycling. This project aims to develop a world-leading platform for city-wide modelling of cycling exposure. This project will provide unparalleled insights into cycling exposure by combining multiple cycling data sources through the use of advanced spatial statistical and machine learning techniques. The expected outcomes of this project are a novel inventory of cycling infrastructure, a cycling route choice modelling system and robust predictions of cycling volumes on individual streets. This project will deliver a step change in cycling that will lead to increased cycling participation, enhanced safety, and improved infrastructure planning, thereby resulting in substantial gains in population and environmental health.Read moreRead less
Navigating flux control through a branched metabolic pathway. This project aims to uncover control points and programmes in the mevalonate pathway, an important cellular metabolic pathway that produces cholesterol and isoprenoids. Knowledge of its regulation is largely restricted to just one enzyme (HMGCR). This project will determine how regulation of the later sterol-producing segment affects the early isoprenoid-segment of the mevalonate pathway; investigate how the two alternate routes to ch ....Navigating flux control through a branched metabolic pathway. This project aims to uncover control points and programmes in the mevalonate pathway, an important cellular metabolic pathway that produces cholesterol and isoprenoids. Knowledge of its regulation is largely restricted to just one enzyme (HMGCR). This project will determine how regulation of the later sterol-producing segment affects the early isoprenoid-segment of the mevalonate pathway; investigate how the two alternate routes to cholesterol synthesis operate and are regulated; and explore a co-ordinated and possibly co-operative transcriptional program. This project is expected to provide valuable knowledge of how cells control these critical lipids, which will ultimately inform better ways to treat diseases of cholesterol excess and defects in this pathway.Read moreRead less
Corporations as sovereigns. This project aims to investigate the history of the relationship between the corporation and the state to understand tensions between states and large multinational corporations. Such tensions are as old as the state system itself and can only be reconstructed through history. The project will focus on chartered companies’ attempt to present themselves as forms of sovereign, or quasi-sovereign, political systems, bringing them into rivalry with the sovereign claims of ....Corporations as sovereigns. This project aims to investigate the history of the relationship between the corporation and the state to understand tensions between states and large multinational corporations. Such tensions are as old as the state system itself and can only be reconstructed through history. The project will focus on chartered companies’ attempt to present themselves as forms of sovereign, or quasi-sovereign, political systems, bringing them into rivalry with the sovereign claims of states. This project is expected to provide a deeper understanding of the political character of corporations.Read moreRead less