Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101484
Funder
Australian Research Council
Funding Amount
$365,000.00
Summary
Developing custom RNA processing tools. The pentatricopeptide repeat (PPR) code has been described as an RNA code that connects specific residues in PPR motifs with the precise recognition of individual nucleotides. It will enable the design of custom RNA-binding proteins with tremendous potential in research and biotechnology. RNA-processing technologies aim to be developed that consist of PPR domains fused with an additional endonuclease domain for cleaving chosen target RNAs. In the longer te ....Developing custom RNA processing tools. The pentatricopeptide repeat (PPR) code has been described as an RNA code that connects specific residues in PPR motifs with the precise recognition of individual nucleotides. It will enable the design of custom RNA-binding proteins with tremendous potential in research and biotechnology. RNA-processing technologies aim to be developed that consist of PPR domains fused with an additional endonuclease domain for cleaving chosen target RNAs. In the longer term, successful technologies will be tested in living organisms for biotechnology applications or in new therapeutic strategies.Read moreRead less
Probing JNK MAPK function with peptide inhibitors. It has generally been accepted that the JNK MAPK family of protein kinases is rapidly and potently activated following the exposure of mammalian cells to stresses and cytokines. However, their biological role has remained controversial. We believe that this problem reflects the lack of a generally applicable and specific JNK MAPK inhibitor. In this project we continue our characterisation of a small peptide inhibitor developed in our laboratori ....Probing JNK MAPK function with peptide inhibitors. It has generally been accepted that the JNK MAPK family of protein kinases is rapidly and potently activated following the exposure of mammalian cells to stresses and cytokines. However, their biological role has remained controversial. We believe that this problem reflects the lack of a generally applicable and specific JNK MAPK inhibitor. In this project we continue our characterisation of a small peptide inhibitor developed in our laboratories. We aim to determine its mechanism of inhibition, the specificity of interaction, and to evolve more effective inhibitors. With these new inhibitors, we can effectively address the biological roles of these kinases.Read moreRead less
Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the p ....Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the period, as well as a greater appreciation of the gender-inclusivity of Stoic philosophy. This should provide significant benefits, such as the development of Stoic therapeutic techniques informed by women’s experiences, and the promotion of gender equality through the recognition of women’s intellectual history.Read moreRead less
Understanding selfie-editing apps in youth visual digital cultures. This project aims to investigate how young people navigate identity and body image concerns online through new digital editing tools provided by selfie-editing apps. The project expects to generate new knowledge about the literacies young people use in reading, evaluating and editing images of themselves, and the role of digital technologies in forming young people’s embodied identities, using an innovative participatory methodo ....Understanding selfie-editing apps in youth visual digital cultures. This project aims to investigate how young people navigate identity and body image concerns online through new digital editing tools provided by selfie-editing apps. The project expects to generate new knowledge about the literacies young people use in reading, evaluating and editing images of themselves, and the role of digital technologies in forming young people’s embodied identities, using an innovative participatory methodology. Expected outcomes include a new evidence base and youth-centred conceptual framework on the connections between youth selfie-editing, body image, and wellbeing. This should provide significant benefits in helping young people to better navigate body image and wellbeing in online cultures.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101382
Funder
Australian Research Council
Funding Amount
$410,154.00
Summary
Nature-culture continuities in medieval philosophy and theology. While nature and culture tend to be opposed to one another in modern philosophy, in medieval thought there are many continuities between the two domains. This project will provide the first sustained historical study of nature-culture continuities in medieval Latin philosophy and theology, examining the areas of: cognition; language; semiotics; ethics and politics; animality; ecology; metaphysics; and God. The project will fill a s ....Nature-culture continuities in medieval philosophy and theology. While nature and culture tend to be opposed to one another in modern philosophy, in medieval thought there are many continuities between the two domains. This project will provide the first sustained historical study of nature-culture continuities in medieval Latin philosophy and theology, examining the areas of: cognition; language; semiotics; ethics and politics; animality; ecology; metaphysics; and God. The project will fill a significant gap in medieval intellectual history, enhance Australia’s research capacity in the history of philosophy and history of theology, and demonstrate how medieval ideas can inform contemporary debates about humanity’s relationship to the natural world. Read moreRead less
Virtue with Aristotle: Recovering an Ancient Ethical Theory for Our Time. This project aims to show how Aristotle’s theory of virtue can guide our individual and collective attempts to live good human lives in challenging times. This project expects to produce the first comprehensive study of Aristotle’s concept of virtue in all three areas of human activity in which he applies it (moral action, theoretical cognition, and craft and artistic production) and to show its relevance for contemporary ....Virtue with Aristotle: Recovering an Ancient Ethical Theory for Our Time. This project aims to show how Aristotle’s theory of virtue can guide our individual and collective attempts to live good human lives in challenging times. This project expects to produce the first comprehensive study of Aristotle’s concept of virtue in all three areas of human activity in which he applies it (moral action, theoretical cognition, and craft and artistic production) and to show its relevance for contemporary ethical theory and practice. Expected outcomes of this project include enhanced understanding of the concepts of virtue and flourishing and their historical roots in Aristotle’s ethical writings. This should provide significant benefits, such as building our collective resilience.Read moreRead less
Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent ....Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent widespread complications associated with pain for all hospitalised patients, irrespective of diagnosis or reason for admission. It is also envisaged that this project will establish a model of change that could be used to facilitate evidence-based practice in other aspects of healthcare apart from pain.Read moreRead less
Evolution and the immune system: genetic differences in immune response between human populations due to adaptation to living in different geo-climatic locations. The project, which investigates the genetics of inter-population differences in immune response, will lead to advances in immunology and population genetics research, explain present population specific differences in disease incidence and possibly forecast future population trends of diseases such as asthma and allergy. The study will ....Evolution and the immune system: genetic differences in immune response between human populations due to adaptation to living in different geo-climatic locations. The project, which investigates the genetics of inter-population differences in immune response, will lead to advances in immunology and population genetics research, explain present population specific differences in disease incidence and possibly forecast future population trends of diseases such as asthma and allergy. The study will strengthen ties with collaborators around the world, thus promoting excellence in Australian research and gain Australia prestige in the international community as a country that produces research of global significance. Understanding the immune system's 'recent evolutionary roots' has implications for the health of Australians, especially in light of Australia's increasingly multi-ethnic background.Read moreRead less