Discovery Early Career Researcher Award - Grant ID: DE210101031
Funder
Australian Research Council
Funding Amount
$458,120.00
Summary
Defining the structural basis of lipid mediated T cell immunity. This project aims to undertake discovery research to investigate the molecular mechanisms underpinning the role of lipids in T cell immunity: an emerging area of immense biological significance. The anticipated goal is to generate new knowledge in the areas of the life sciences, by using a multidisciplinary approach that includes structural biology, mass spectrometry, biophysics, and cellular immunology, to gain fundamental insight ....Defining the structural basis of lipid mediated T cell immunity. This project aims to undertake discovery research to investigate the molecular mechanisms underpinning the role of lipids in T cell immunity: an emerging area of immense biological significance. The anticipated goal is to generate new knowledge in the areas of the life sciences, by using a multidisciplinary approach that includes structural biology, mass spectrometry, biophysics, and cellular immunology, to gain fundamental insight into molecular determinants that govern lipid mediated immunity. Expected outcomes and benefits of this project include building international and interdisciplinary collaborations to enhance national research capacity, and provide marked advancement of core knowledge in the biological sciences.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101042
Funder
Australian Research Council
Funding Amount
$421,485.00
Summary
Molecular insights into lipid-mediated T cell immunity. This project involves the discovery of novel lipids produced by the microbiome that play a significant role in T cell-mediated immunity. Using a combination of cutting-edge technologies such as mass spectrometry, protein crystallography, immunology and biophysics, this project will elucidate the molecular factors that govern the interaction between the identified lipids and T cells. This innovative research will provide fundamental insights ....Molecular insights into lipid-mediated T cell immunity. This project involves the discovery of novel lipids produced by the microbiome that play a significant role in T cell-mediated immunity. Using a combination of cutting-edge technologies such as mass spectrometry, protein crystallography, immunology and biophysics, this project will elucidate the molecular factors that govern the interaction between the identified lipids and T cells. This innovative research will provide fundamental insights into the recognition mechanism of lipids by T cells at a molecular level, thus broadening our knowledge in the field of biological sciences. The expected research outcomes will increase Australia’s international research standing in this burgeoning area of lipid-mediated T cell immunity.Read moreRead less