Deformable Surfaces Supporting 3D Tactile Human Computer Interactions. This project will support Research Priority 3: Frontier Technologies for Building and Transforming Australian Industries. The results will provide information that will further build our understanding of human computer interactions. Digital Foam supports Smart Information Use by providing a new interaction paradigm for existing and new creative applications for digital technologies. The new form of interaction provides a new ....Deformable Surfaces Supporting 3D Tactile Human Computer Interactions. This project will support Research Priority 3: Frontier Technologies for Building and Transforming Australian Industries. The results will provide information that will further build our understanding of human computer interactions. Digital Foam supports Smart Information Use by providing a new interaction paradigm for existing and new creative applications for digital technologies. The new form of interaction provides a new computer interaction product in itself and the ability to make a more efficient creative environment for designers of 3D content, multi-media and manufacturing design. This technology supports the ability of organisations to operate virtually and collaborate across large distances in Australia and internationally.Read moreRead less
Molecular mechanisms of catalysis and the basis of substrate specificity in polysaccharide hydrolases. Reaction intermediates along hydrolytic pathways and molecular determinants of substrate specificity of barley B-glucan exo- and endohydrolases will be defined using crystallographic and kinetic analyses. These enzymes are of central importance in cell wall metabolism during development of higher plants, and in plant-pathogen interactions. Realization of the project objectives will not only pro ....Molecular mechanisms of catalysis and the basis of substrate specificity in polysaccharide hydrolases. Reaction intermediates along hydrolytic pathways and molecular determinants of substrate specificity of barley B-glucan exo- and endohydrolases will be defined using crystallographic and kinetic analyses. These enzymes are of central importance in cell wall metabolism during development of higher plants, and in plant-pathogen interactions. Realization of the project objectives will not only provide fundamental information on catalytic mechanisms, but will also provide opportunities to manipulate enzyme specificity. Further, site-directed mutagenesis of the enzymes will be used to generate glycosynthases, which will be evaluated for their ability to synthesise novel oligosaccharide and polysaccharide products, some of which might show immunomodulating activity.Read moreRead less
Huntingtin-associated protein 1 controls cell communication. The purpose of this study is to identify the mechanisms by which a novel regulator of cell communication which we have identified is able to control the release of chemical signals from a cell. This project will provide critical insight into a cellular pathway that underlies hormone secretion, neurotransmission and higher brain functions.
Continuous process improvement through workstation feedback for General Practice medicine using experts-in-the-loop data mining. This project investigates the iterative use of data mining results to allow experts to construct feedback to influence subsequent production work. We explore the problem in the context of General Practice medicine by having General Practitioners (GPs) review emerging patterns from their own practice's electronic medical records and author feedback to discourage undesi ....Continuous process improvement through workstation feedback for General Practice medicine using experts-in-the-loop data mining. This project investigates the iterative use of data mining results to allow experts to construct feedback to influence subsequent production work. We explore the problem in the context of General Practice medicine by having General Practitioners (GPs) review emerging patterns from their own practice's electronic medical records and author feedback to discourage undesirable patterns. The work will have immediate applicability to medical practice and will drive innovation in data mining method, notably for efficient identification of temporal and complex niche patterns. More broadly, the work will extend the way data mining is used to create new expectations of workstation behaviour.Read moreRead less
Interacting with visualisations of extremely large graph structures on large displays. The latest technological progressions have delivered very large data sets that can be modelled as graphs or networks. Examples include: social networks, biological data, and software structures. This project will develop techniques to allow users to visualise the graphs in the entirety and directly interact with data.
Through Walls Collaboration to Support Command and Control Operations with Eyes and Ears in the Field. Australia is a geographically dispersed country with locations of high concentrations of technology resources. Australia requires the ability to gather real time intelligence information in the field to support planning and operational decisions by a command team for military and civil defence operations. Currently Australia supports such operations in remote areas of the country and numerous o ....Through Walls Collaboration to Support Command and Control Operations with Eyes and Ears in the Field. Australia is a geographically dispersed country with locations of high concentrations of technology resources. Australia requires the ability to gather real time intelligence information in the field to support planning and operational decisions by a command team for military and civil defence operations. Currently Australia supports such operations in remote areas of the country and numerous overseas operations. A major research outcome is the design and development of interaction techniques for the mobile users in through walls collaboration systems to control and manipulate augmented reality information in the field across a number of application domains, such as medical, maintenance, military, search and rescue, and GIS visualization.Read moreRead less
Interactions between cells and extracellular matrix in the epithelial-mesenchymal transition of the ovarian follicular stratified epithelium. The lining of many mammalian organs and cavities contain cells that can transform into different cells to bring about organ development or repair but if it goes horribly wrong the cells become metastatic cancers. This project examines the key features of this process especially the roles of matrix that develops around the cells in this process.
Male to female sperm signalling – a new role for sperm in reproduction? Male seminal fluid is commonly thought simply to provide sperm for conception. This project aims to investigate a lesser known action of sperm: modifying the female immune response to increase the chances of reproductive success. The project aims to define the molecular pathway through which sperm interact with female cells, particularly how B-defensins on sperm bind to Toll-like receptors to stimulate female immune toleranc ....Male to female sperm signalling – a new role for sperm in reproduction? Male seminal fluid is commonly thought simply to provide sperm for conception. This project aims to investigate a lesser known action of sperm: modifying the female immune response to increase the chances of reproductive success. The project aims to define the molecular pathway through which sperm interact with female cells, particularly how B-defensins on sperm bind to Toll-like receptors to stimulate female immune tolerance. The project plans to use embryo transfer and genetic mouse models to determine the physiological benefit of sperm signalling. Evidence that seminal fluid signalling operates in mammals to ensure optimal female reproductive investment would advance knowledge of the male contribution to the reproductive process.Read moreRead less
Combating fungal biofilm growth on surfaces. This project aims to establish a scientific basis for the design and development of thin coatings, for use on biomedical devices, that can resist the attachment of fungal cells and the ensuing formation of infectious fungal biofilms on their surfaces. Advancing mechanistic understanding of how physico-chemical properties of materials surfaces influence fungal attachment will enable rational development and optimisation of coating chemistries and struc ....Combating fungal biofilm growth on surfaces. This project aims to establish a scientific basis for the design and development of thin coatings, for use on biomedical devices, that can resist the attachment of fungal cells and the ensuing formation of infectious fungal biofilms on their surfaces. Advancing mechanistic understanding of how physico-chemical properties of materials surfaces influence fungal attachment will enable rational development and optimisation of coating chemistries and structures. Tethered antifungal compounds will be added to polymer surfaces by controlled polymerisation methods to provide active deterrence; factors such as conformational flexibility will be studied to optimise coatings, which may will prevent life-threatening infections and reduce healthcare costs.Read moreRead less