Operator Decision Modelling in Autonomous Systems. The incorporation of humans as decision-makers into a complex system comprising of many autonomous agents is becoming increasingly important in areas such as defence, search-and-rescue, special emergency services, bush-fire and ecology management. This project will address how human decisions are made in such systems through the formulation and demonstration of innovative algorithms which model the operator decision making process. Generating so ....Operator Decision Modelling in Autonomous Systems. The incorporation of humans as decision-makers into a complex system comprising of many autonomous agents is becoming increasingly important in areas such as defence, search-and-rescue, special emergency services, bush-fire and ecology management. This project will address how human decisions are made in such systems through the formulation and demonstration of innovative algorithms which model the operator decision making process. Generating solutions to this increasingly important area will provide Australia's industry and community services the necessary knowledge for deploying such systems and thus improving service effectiveness, as well as the implementation of autonomous systems into new areas and thus increasing economic growth.Read moreRead less
A microscopical examination of curdlan production by an Agrobacterium sp. We will investigate the secretion of the insoluble polysaccharide curdlan, a (1,3)-beta-glucan, from the surfaces of Agrobacterium cells and the assembly of the individual polysaccharide chains into microfibrils. Using state-of-the-art techniques in time lapse and electron microscopy we will compare the images of wild type curdlan-producing cells with those of mutants impaired in the production of curdlan. The outputs will ....A microscopical examination of curdlan production by an Agrobacterium sp. We will investigate the secretion of the insoluble polysaccharide curdlan, a (1,3)-beta-glucan, from the surfaces of Agrobacterium cells and the assembly of the individual polysaccharide chains into microfibrils. Using state-of-the-art techniques in time lapse and electron microscopy we will compare the images of wild type curdlan-producing cells with those of mutants impaired in the production of curdlan. The outputs will be information on the mechanics of curdlan production that will complement that emerging from our molecular biological and biochemical studies. These will have implications for understanding bacterial polysaccharide production in general and may have a commercial outcome in enhanced curdlan production.Read moreRead less
How, What and Who in Human Communication: Movement of Face and Voice. The aim of this project is to identify the essential characteristics of tone, affect, and identity from face and voice using a combination of signal processing, biological, and behavioural techniques in order to develop a comprehensive model of auditory-visual speech processing and communication. This research will significantly improve understanding of the basis of auditory-visual perception and production in tonal languages ....How, What and Who in Human Communication: Movement of Face and Voice. The aim of this project is to identify the essential characteristics of tone, affect, and identity from face and voice using a combination of signal processing, biological, and behavioural techniques in order to develop a comprehensive model of auditory-visual speech processing and communication. This research will significantly improve understanding of the basis of auditory-visual perception and production in tonal languages and in affective communication, facilitate links between neurophysiological processes and auditory-visual speech processing; and contribute to applications in automatic person recognition, automatic speech recognition, text-to-speech systems, and talking head aids for the hearing impaired.Read moreRead less
Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will pr ....Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will provide longer lasting implants and reduce the need for repeated operations. This will improve the quality of life for implant recipients and reduce health care costs.Read moreRead less
Automated Interaction Technologies for Mobile Hand-held Devices. This project is concerned with developing intelligent technologies that support human interaction through handheld devices, connected to wireless digital networks. Intelligent software assistants running on these devices will interact with one another in order to coordinate the activities of multiple users. Such automated coordination may facilitate scheduling of meetings, collaboration among different members of a team, and negoti ....Automated Interaction Technologies for Mobile Hand-held Devices. This project is concerned with developing intelligent technologies that support human interaction through handheld devices, connected to wireless digital networks. Intelligent software assistants running on these devices will interact with one another in order to coordinate the activities of multiple users. Such automated coordination may facilitate scheduling of meetings, collaboration among different members of a team, and negotiating conflicts that may arise between the activities of different connected users. This will enable context-dependent task support and coordination of workers involved in industrial applications involving mobility and dynamism.Read moreRead less
Synthesis of substrate analogues for probing catalytic mechanisms and specificity of enzymes involved in the metabolism of plant polysaccharides. The project is aimed at strengthening collaborations between research groups in Adelaide and France, with the specific objective of synthesizing substrate analogues as probes of enzymatic mechanisms and substrate specificity in polysaccharide hydrolases and synthases of barley. The chemical expertise resides in France, while the enzymatic work will be ....Synthesis of substrate analogues for probing catalytic mechanisms and specificity of enzymes involved in the metabolism of plant polysaccharides. The project is aimed at strengthening collaborations between research groups in Adelaide and France, with the specific objective of synthesizing substrate analogues as probes of enzymatic mechanisms and substrate specificity in polysaccharide hydrolases and synthases of barley. The chemical expertise resides in France, while the enzymatic work will be conducted largely in Australia. Exchange of research staff, particularly at the postgraduate student and research associate levels, is considered essential to capture the benefits of the complementary expertise and to extend an existing international collaboration. The target enzymes are of central importance in cell wall metabolism during development of higher plants.Read moreRead less
Dynamic signaling pathways of dispersal in bacterial biofilms. This Breakthrough Science project will result in an increased understanding of the molecular processes that govern biofilm development and dispersal. While the outcomes will be directly applicable where P. aeruginosa infections continue to cause health-threatening conditions, such as in Cystic Fibrosis chronic infections, it will also be instrumental for the rational design of novel products and strategies to control biofilms of othe ....Dynamic signaling pathways of dispersal in bacterial biofilms. This Breakthrough Science project will result in an increased understanding of the molecular processes that govern biofilm development and dispersal. While the outcomes will be directly applicable where P. aeruginosa infections continue to cause health-threatening conditions, such as in Cystic Fibrosis chronic infections, it will also be instrumental for the rational design of novel products and strategies to control biofilms of other single species or of mixed species populations in many other settings. Countless environmental, industrial and clinical applications will benefit from improved antimicrobial strategies and reduced usage of antibiotics.Read moreRead less
Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability ....Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability to control cellular responses to implants. Such improved response will result in better health outcomes for patients, and outcomes in the form of papers and intellectual property.
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Heparan sulfate proteoglycan from smooth muscle cell basal lamina: It's role in cell signalling. Heart disease is the major killer of people in the Western world. central to this disease is the killing of heart muscle tissue to it being starved of oxygen via a "heart attack". One of the common treatments is coronary artery bypass surgery, however, the supply of vessels that can be used is limited. In order to provide an alternative supply of vessels, we are aiming to engineer blood vessels i ....Heparan sulfate proteoglycan from smooth muscle cell basal lamina: It's role in cell signalling. Heart disease is the major killer of people in the Western world. central to this disease is the killing of heart muscle tissue to it being starved of oxygen via a "heart attack". One of the common treatments is coronary artery bypass surgery, however, the supply of vessels that can be used is limited. In order to provide an alternative supply of vessels, we are aiming to engineer blood vessels in the laboratory. The major cell of the wall of arteries, the smooth muscle cell, is critical to normal functioning and integration of these transplanted arteries. To do this we will need to understand the cell signalling responses of these cells in relation to molecules in their surrounding environment.Read moreRead less
Acoustic Filter Functions from Morphological Measurements. This project works toward enabling the broadcast of high-fidelity 3D audio. By developing an efficient technique for deriving personalised acoustic filter functions based on image data of the listener's head and ears, we hope to enable high-fidelity 3D audio decoding and rendering. Morphological parameterisation techniques and databases recently developed at the University of York will be combined with the statistical synthesis technique ....Acoustic Filter Functions from Morphological Measurements. This project works toward enabling the broadcast of high-fidelity 3D audio. By developing an efficient technique for deriving personalised acoustic filter functions based on image data of the listener's head and ears, we hope to enable high-fidelity 3D audio decoding and rendering. Morphological parameterisation techniques and databases recently developed at the University of York will be combined with the statistical synthesis techniques and databases developed at the University of Sydney to substantially reduce the development time required for either group alone. Psychoacoustic experiments carried out at the University of Sydney will demonstrate the fidelity of the delivered 3D audio.Read moreRead less