CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research wil ....CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research will provide new data on the fundamental cellular and molecular events that are required to trigger the birth, differentiation and conditions for growth of new neurons in the adult nervous system. The generation of such insights will be critical for any translational research.
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Rethinking auditory alarms. This project aims to investigate whether auditory displays that give listeners background information about the status of monitored processes will lead to better situation awareness than conventional auditory alarms. Recent efforts to combat alarm fatigue by reducing auditory alarms may cause listeners to lose awareness of early process deterioration and its context. This project will investigate benefits of intermittent displays summarising process status with sound ....Rethinking auditory alarms. This project aims to investigate whether auditory displays that give listeners background information about the status of monitored processes will lead to better situation awareness than conventional auditory alarms. Recent efforts to combat alarm fatigue by reducing auditory alarms may cause listeners to lose awareness of early process deterioration and its context. This project will investigate benefits of intermittent displays summarising process status with sound or time-compressed speech while participants perform specific ongoing tasks. Anticipated outcomes are safer, more effective and better tolerated ways of monitoring processes than conventional auditory alarms. Results apply to healthcare, transportation and process industries.Read moreRead less
Investigating the molecular basis of T-cell receptor cross-reactivity. This project will explore the basis of unexpected immune reactions whereby the immune system mistakes one molecular structure for another, a phenomenon known as cross-reactivity. This project will examine how often this is due to molecular mimicry, potentially explaining why immune T cells sometimes react inappropriately to different agents.