The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100074
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genet ....Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genetic and acquired disorders across the life-span. Remote viewing and analysis capabilities will help overcome the 'tyranny of distance', increasing national access to the facility. Repositories of digitised images will increase the availability of valuable research material to other Australian and international researchers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347194
Funder
Australian Research Council
Funding Amount
$411,000.00
Summary
Interactive Television Audience Research Laboratory. Interactive Television is a rapidly emerging platform for global media and e-commerce that is poised to dramatically transform the role of television in society. In collaboration with a range of university and industry partners, Murdoch University aims to establish Australia's first dedicated public research laboratory for assessing consumer motivation, evaluating program usability and theorising audience response to Interactive Television app ....Interactive Television Audience Research Laboratory. Interactive Television is a rapidly emerging platform for global media and e-commerce that is poised to dramatically transform the role of television in society. In collaboration with a range of university and industry partners, Murdoch University aims to establish Australia's first dedicated public research laboratory for assessing consumer motivation, evaluating program usability and theorising audience response to Interactive Television applications. The laboratory will feature specialised testing equipment designed to emulate real-world digital broadcasting environments, enabling rich data on viewing behaviour to be collected and analysed. As an independent facility, the laboratory will provide an invaluable resource for academic and industry research.Read moreRead less
Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a vari ....Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a variety of surveillance techniques will evaluate content design and user response. Children's viewing habits will be evaluated within a social context (the home) and a mobile lab setting using qualitative and quantitative assessment. The results will identify effective ways to produce meaningful interactivity and will encourage future industry based research.Read moreRead less
Production Challenges in the On-Line Learning Environment. The shift of responsibility from teacher-centred learning to learner-centred learning has raised important questions of access for diverse groups in Australia and overseas. The project seeks to investigate new delivery mechanisms that respond to worldwide trends in virtual communities and self-directed learning. This research will explore the relationship between content pedagogy, use of technology, and work-related issues and expectatio ....Production Challenges in the On-Line Learning Environment. The shift of responsibility from teacher-centred learning to learner-centred learning has raised important questions of access for diverse groups in Australia and overseas. The project seeks to investigate new delivery mechanisms that respond to worldwide trends in virtual communities and self-directed learning. This research will explore the relationship between content pedagogy, use of technology, and work-related issues and expectations. It will adopt a qualitative and quantitative research methodology in identifying opportunities, producing a learning prototype, testing and trialing that prototype and applying research outcomes in the context of emergent new educational models that draw upon convergent media.Read moreRead less
Special Research Initiatives - Grant ID: SR0354753
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
MESH: amalgamating innovative teams of cross-disciplinary collaborators for creativity in Media-arts, E-culture, Science and Humanities. MESH is a cross-disciplinary network that amalgamates a national array of sub-networks of research in digital arts, ICT and cross-cultural and policy negotiation. It boosts Australia's existing cross-disiciplinary strengths in Media-arts, E-culture, Science and Humanities by encouraging existing digital sub-networks to grow together via well-brokered communic ....MESH: amalgamating innovative teams of cross-disciplinary collaborators for creativity in Media-arts, E-culture, Science and Humanities. MESH is a cross-disciplinary network that amalgamates a national array of sub-networks of research in digital arts, ICT and cross-cultural and policy negotiation. It boosts Australia's existing cross-disiciplinary strengths in Media-arts, E-culture, Science and Humanities by encouraging existing digital sub-networks to grow together via well-brokered communications and demonstrations online and on-location. Progressively, MESH participants will discover existing harmonies whilst also inventing new languages and protocols leading to breakthroughs in cross-disciplinary collaboration and innovation. MESH encourages a 'paradigm shift' in digital research, realising the extraordinary potential that is ready but latent across Australia's arts and sciences.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100001
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Automated Vehicles in Rural and Remote Regions. The Centre will build skills and capability to test and deploy safe, socially acceptable, automated vehicles (AV) for rural, regional and remote Australian public roads, where manufacturing, agriculture, mining and defence industries face significant challenges of driver shortages, rising costs, long distances, rough roads, and environmental impacts. The centre will unite technology providers, regulators, government and end ....ARC Training Centre for Automated Vehicles in Rural and Remote Regions. The Centre will build skills and capability to test and deploy safe, socially acceptable, automated vehicles (AV) for rural, regional and remote Australian public roads, where manufacturing, agriculture, mining and defence industries face significant challenges of driver shortages, rising costs, long distances, rough roads, and environmental impacts. The centre will unite technology providers, regulators, government and end users with world-leading interdisciplinary researchers to create new human-AV systems, datasets, frameworks, case studies, platforms, and a vastly upskilled workforce. This will reduce transport costs, increase capacity, boost supply chain efficiency and resilience, improve road safety, and elevate Australian capability.Read moreRead less
ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longi ....ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longitudinal family cohort study and children’s technology laboratories. The Centre will address tensions in a contested field to inform government and non-government policy, technology innovation, and develop programs and guidelines for children, families, educators and technology developers. Read moreRead less