Coach My Ride: Mentorable Interfaces to support Older Australians' Mobility. This project aims to co-design new interfaces to support older Australians to collaboratively learn the use of automated vehicles. We will seek to understand the needs, expectations, and challenges of urban and rural residents, and the peer support strategies they deploy to learn technology. Mobility is key to the wellbeing of older people, but automated vehicles that are too complex will fail to deliver their promise o ....Coach My Ride: Mentorable Interfaces to support Older Australians' Mobility. This project aims to co-design new interfaces to support older Australians to collaboratively learn the use of automated vehicles. We will seek to understand the needs, expectations, and challenges of urban and rural residents, and the peer support strategies they deploy to learn technology. Mobility is key to the wellbeing of older people, but automated vehicles that are too complex will fail to deliver their promise of independent ageing. Outcomes will be a new theory of collaborative learning and new mentorable interfaces to allow older adults to mentor each other to access and use new mobility solutions. This will contribute to narrow the digital and mobility gap improving the independence, safety and wellbeing of ageing Australians.Read moreRead less
Designing distanced intergenerational interaction with tangible technology. Older people and their young relatives/grandchildren who are geographically distanced cannot currently experience closeness in tangible ways, which are the natural ways they would play and build relationships in “real” life. Enabling this connection would have positive impacts for both groups, and two types of technologies – Mixed Reality and Tangibles - can be explored to allow us to understand how to do this. We will d ....Designing distanced intergenerational interaction with tangible technology. Older people and their young relatives/grandchildren who are geographically distanced cannot currently experience closeness in tangible ways, which are the natural ways they would play and build relationships in “real” life. Enabling this connection would have positive impacts for both groups, and two types of technologies – Mixed Reality and Tangibles - can be explored to allow us to understand how to do this. We will develop approaches to distanced tangible intergenerational interaction which are designed specifically to increase intergenerational closeness and to be innovative and subtle so that they fit seamlessly into the lives of older people and young children.Read moreRead less
Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodellin ....Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodelling is organised at a cell-type level is not understood. Here we aim to close this knowledge gap, using cutting-edge technology including bioconjugation and ultrasound-mediated cargo delivery. Together, this project aims to contribute to a deeper understanding of this major brain compartment in neuronal function. Read moreRead less
A human-centric eXplainable Automated Vehicle. The aim is to create a computational model to address the inability of Automated Vehicles (AV), powered by Artificial intelligence, to self explain their behaviours. This project applies novel multidisciplinary methodologies in a real-world self-driving setting to formalise the essence of driving explanations. It explores the when, why and how a driver is seeking an explanation and what type of automated explanation is truly human-interpretable. Exp ....A human-centric eXplainable Automated Vehicle. The aim is to create a computational model to address the inability of Automated Vehicles (AV), powered by Artificial intelligence, to self explain their behaviours. This project applies novel multidisciplinary methodologies in a real-world self-driving setting to formalise the essence of driving explanations. It explores the when, why and how a driver is seeking an explanation and what type of automated explanation is truly human-interpretable. Expected outcomes include the discovery of an acceptable, transparent and ethical explanation system that helps humans to understand the AVs decision making. This field will continue to rise in prominence and produce much-needed work to improve the widespread adoption of AVs.Read moreRead less
Wearable displays for high-tempo work in mission-critical worlds. This project aims to investigate how effectively head-worn display technology can support mobile work in complex high-tempo environments where workers must complete tasks quickly, handle competing demands, and manage interruptions. The project will draw on field investigations to specify functions and formats for head-worn displays, and will conduct laboratory and simulation studies to test the relative advantages of head-worn dis ....Wearable displays for high-tempo work in mission-critical worlds. This project aims to investigate how effectively head-worn display technology can support mobile work in complex high-tempo environments where workers must complete tasks quickly, handle competing demands, and manage interruptions. The project will draw on field investigations to specify functions and formats for head-worn displays, and will conduct laboratory and simulation studies to test the relative advantages of head-worn displays versus tablet computers. Work environments benefitting from the project should include emergency response, triage, defence, and field service industries.Read moreRead less
Enabling Situated Immersive Science Collaboration with Remote Sensing Data . This project aims to help scientists communicate and collaborate in immersive environments. Fieldwork is more valuable to scientists than looking at abstract remote data, but expense, danger, or inaccessible locations often stand in the way. This project will address this issue by researching and designing immersive environments that combine remote data with visualisations and new interaction tools for science teams to ....Enabling Situated Immersive Science Collaboration with Remote Sensing Data . This project aims to help scientists communicate and collaborate in immersive environments. Fieldwork is more valuable to scientists than looking at abstract remote data, but expense, danger, or inaccessible locations often stand in the way. This project will address this issue by researching and designing immersive environments that combine remote data with visualisations and new interaction tools for science teams to make sense of spatial and temporal aspects of data. Outcomes will include new presentation and interaction methods, an evaluation with geoscientists, and a framework for designing interactive systems that enable situated interactions. Benefits will include helping Australian scientists overcome distance in their research. Read moreRead less
Novel role of RNA methylation in neuronal homeostasis. This proposal is aimed at understanding the RNA signalling that takes place in neuronal homeostatic response. The crucial role of neuronal homeostasis for normal brain function is evidenced throughout the nervous system; however, the precise underlying mechanisms are still not well understood. The proposed research will utilise high-throughput sequencing approaches coupled with biochemical, molecular and cell biological assays to provide mec ....Novel role of RNA methylation in neuronal homeostasis. This proposal is aimed at understanding the RNA signalling that takes place in neuronal homeostatic response. The crucial role of neuronal homeostasis for normal brain function is evidenced throughout the nervous system; however, the precise underlying mechanisms are still not well understood. The proposed research will utilise high-throughput sequencing approaches coupled with biochemical, molecular and cell biological assays to provide mechanistic insights into the molecular processes that control neuronal homeostatic responses. This will elucidate how neural plasticity and network stability are maintained, a process that is critical for our understanding of sensory processing, learning and memory throughout life.Read moreRead less
Old brain cells perform new tricks to allow life-long learning. In the brain, nerve cells transmit electrical signals more quickly and reliably when they are insulated. The insulating cells undergo small adaptive changes that speed up information transfer during learning, and the faster the electrical signal, the better the learning outcomes. This project aims to understand the signals that direct insulating cells to adapt and support life-long learning. In the longer term, this knowledge may be ....Old brain cells perform new tricks to allow life-long learning. In the brain, nerve cells transmit electrical signals more quickly and reliably when they are insulated. The insulating cells undergo small adaptive changes that speed up information transfer during learning, and the faster the electrical signal, the better the learning outcomes. This project aims to understand the signals that direct insulating cells to adapt and support life-long learning. In the longer term, this knowledge may be used to: develop interventions that improve learning and educational outcomes; counteract age-related memory decline and enable longer work force participation; develop strategies to circumvent the memory loss caused by brain diseases, or improve the design of computer hardware.Read moreRead less
Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic ....Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.Read moreRead less
Understanding the generation of hypothalamic sleep neurons. This Project aims to investigate the mechanisms controlling the formation of the sleep neurons in the hypothalamus. We all sleep, and normal sleep-wake cycles play a central role in our biology. The functional role of these sleep neurons in the mature brain are well established. However, how the neurons are generated during development is very poorly defined. This project aims to address this critical knowledge gap, and will greatly inc ....Understanding the generation of hypothalamic sleep neurons. This Project aims to investigate the mechanisms controlling the formation of the sleep neurons in the hypothalamus. We all sleep, and normal sleep-wake cycles play a central role in our biology. The functional role of these sleep neurons in the mature brain are well established. However, how the neurons are generated during development is very poorly defined. This project aims to address this critical knowledge gap, and will greatly increase our understanding of how the development of this critical aspect of organismal function is orchestrated during development. This project will also develop bioinformatics tools with broad utility within the biosciences field and enhance the capacity for interdisciplinary international collaborations.Read moreRead less