Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Engaging Augmented Reality on 3D Head Up Displays to Reduce Risky Driving. This project aims to reduce risky driving behaviours through novel augmented reality applications for three-dimensional head-up displays, making safe driving more engaging so that drivers will take less risk. Over 1 million people are killed and 50 million are seriously injured on roads each year worldwide. Risky driving behaviours (speeding and distracted driving) are major causes. This project intends to produce novel i ....Engaging Augmented Reality on 3D Head Up Displays to Reduce Risky Driving. This project aims to reduce risky driving behaviours through novel augmented reality applications for three-dimensional head-up displays, making safe driving more engaging so that drivers will take less risk. Over 1 million people are killed and 50 million are seriously injured on roads each year worldwide. Risky driving behaviours (speeding and distracted driving) are major causes. This project intends to produce novel in-car interaction design implementations, provide important visual design guidelines for future display technologies, and provide novel road safety interventions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101542
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Risky Gadgets to the Rescue: Designing Personal Ubicomp Devices to Foster Safer Driving Behaviours in Young Males. Young males are over-represented in road crashes. Part of the problem is their proneness to boredom, a hardwired personality factor that can lead to risky driving or distractions. This project aims to design innovative ubiquitous computing technologies that make safe driving more stimulating and pleasurable. This research will inform the future design of personal ubiquitous devices ....Risky Gadgets to the Rescue: Designing Personal Ubicomp Devices to Foster Safer Driving Behaviours in Young Males. Young males are over-represented in road crashes. Part of the problem is their proneness to boredom, a hardwired personality factor that can lead to risky driving or distractions. This project aims to design innovative ubiquitous computing technologies that make safe driving more stimulating and pleasurable. This research will inform the future design of personal ubiquitous devices that pose a threat to road safety, by replacing the stimuli from risky driving with safer stimuli and simulating risk to increase risk perception when it is actually not present. This project aims to reduce risky driving behaviours, and, in the process, advance our knowledge about the role of boredom in the road safety context.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101151
Funder
Australian Research Council
Funding Amount
$398,000.00
Summary
Designing augmented eating interfaces to promote mindful eating. This project aims to develop and test novel augmented eating interfaces in order to address the contradiction between the concept of mindful eating (no distractions) and the reality of screen cultures (eating with screens). Eating while watching screens can be problematic because it can cause overeating, which can manifest into bigger health concerns such as obesity and heart disease. This project expects to generate new knowledge ....Designing augmented eating interfaces to promote mindful eating. This project aims to develop and test novel augmented eating interfaces in order to address the contradiction between the concept of mindful eating (no distractions) and the reality of screen cultures (eating with screens). Eating while watching screens can be problematic because it can cause overeating, which can manifest into bigger health concerns such as obesity and heart disease. This project expects to generate new knowledge in the field of human-food interaction. It presents two new augmented eating systems and a socio-technological study of these systems in use within Australian households. The expected outcomes include a framework on how to design interactive systems that encourage mindful eating without compromising the pleasures of screen-based media and the eating experience, and a greater theoretical understanding of how to support mindful eating in everyday practice.Read moreRead less
Intention-aware cooperative driving behaviour model for Automated Vehicles. This project aims to investigate humans' cooperation with automated systems by conceptualising joint intention awareness. This project expects to generate knowledge about a new cooperative driving behaviour model for automated vehicles, utilising a transdisciplinary approach that mixes human-centric methods with deep learning techniques. Intended outcomes are new joint intention awareness theory, new interface for automa ....Intention-aware cooperative driving behaviour model for Automated Vehicles. This project aims to investigate humans' cooperation with automated systems by conceptualising joint intention awareness. This project expects to generate knowledge about a new cooperative driving behaviour model for automated vehicles, utilising a transdisciplinary approach that mixes human-centric methods with deep learning techniques. Intended outcomes are new joint intention awareness theory, new interface for automated vehicles, new methodology for cooperative behaviour research, and enhanced research capacity. The expected significant benefits are for automated systems to become more predictable, acceptable, readable and safer to use by everyday people.Read moreRead less
Participatory Visualisation & Assessment of Risks: A Crowdsourcing Approach. The aim of this study is to develop and evaluate innovative interaction and visualisation approaches that allow the insurance sector to include social media and crowdsourced data in risk identification and assessment. This data, combined with traditional risk assessment information, offers time-critical insights into emerging hazards and threats. The study aims to deliver methods and tools to crowdsource data from contr ....Participatory Visualisation & Assessment of Risks: A Crowdsourcing Approach. The aim of this study is to develop and evaluate innovative interaction and visualisation approaches that allow the insurance sector to include social media and crowdsourced data in risk identification and assessment. This data, combined with traditional risk assessment information, offers time-critical insights into emerging hazards and threats. The study aims to deliver methods and tools to crowdsource data from contributors through sensing and active sharing, as well as novel interaction and visualisation approaches to aid in the analysis of the resulting data. The project intends to benefit both the insurers and the insured by making non-traditional data sources available for risk assessment and prevention.Read moreRead less
Understanding the molecular mechanisms regulating neuronal fusion. Neurons are tightly connected individual cells that communicate through chemical and electrical signals, and this project aims to discover the key molecules that allow these cells to remain as individual units without fusing with each other. The nervous system, unlike other tissues, is made of discrete individual cells, connected by chemical and electrical synapses but not by cytoplasmic continuity. However, how this is achieved ....Understanding the molecular mechanisms regulating neuronal fusion. Neurons are tightly connected individual cells that communicate through chemical and electrical signals, and this project aims to discover the key molecules that allow these cells to remain as individual units without fusing with each other. The nervous system, unlike other tissues, is made of discrete individual cells, connected by chemical and electrical synapses but not by cytoplasmic continuity. However, how this is achieved and how neurons maintain their individuality during development, remodelling and ageing is unknown. The project aims to address this gap using a genetic approach and the nematode Caenorhabditis elegans as an experimental system. The results may provide insights into how the nervous system develops and functions.Read moreRead less
Interactions between phenome and genome at developing CNS synapses during synaptic refinement. Activity-dependent changes in synaptic transmission are vital to development and function of central neuronal networks. However, the critical factors regulating developmental changes in synaptic signals remain largely unknown. We will correlate functional changes in synaptic responses at glutamate-releasing synapses with changes in glutamate receptor composition at a critical period during developmen ....Interactions between phenome and genome at developing CNS synapses during synaptic refinement. Activity-dependent changes in synaptic transmission are vital to development and function of central neuronal networks. However, the critical factors regulating developmental changes in synaptic signals remain largely unknown. We will correlate functional changes in synaptic responses at glutamate-releasing synapses with changes in glutamate receptor composition at a critical period during development, test whether synaptic activation of receptors is required for these changes and define the pattern of activity-dependent changes in gene expression necessary for developmental changes in synaptic transmission. Understanding this interaction between synaptic phenome and activity-dependent genomic expression will expand our understanding of brain development and function.Read moreRead less
Inhibition Of Cellcell Actin-based Motility During Poxvirus Infection By The Kinase Inhibitor Glivec
Funder
National Health and Medical Research Council
Funding Amount
$92,950.00
Summary
Although smallpox, one of the deadliest human pathogens, was eradicated in 1980, the current global climate has resulted in fears that smallpox may be used as a biological weapon. Unfortunately the smallpox vaccine poses a serious health hazard to certain people. We have shown that Glivec, a drug used to treat cancer, has potent anti-viral affects on poxvirus replication. This project will test the effectiveness of Glivec in treating smallpox in an animal model and study how it acts.
Scalable Visual Analytics for Uncertain Dynamic Networks. Technological advances have provided a data deluge over the past few years, and have led to many large uncertain and dynamic network models. This includes terrorist networks, marketing networks, facebook networks, various biological networks, and software engineering structures. Human understanding of such networks is difficult. This project aims to provide new methods for visual analysis of large uncertain dynamic networks such as these. ....Scalable Visual Analytics for Uncertain Dynamic Networks. Technological advances have provided a data deluge over the past few years, and have led to many large uncertain and dynamic network models. This includes terrorist networks, marketing networks, facebook networks, various biological networks, and software engineering structures. Human understanding of such networks is difficult. This project aims to provide new methods for visual analysis of large uncertain dynamic networks such as these. The algorithms developed in the project will help security analysts to monitor illegal behaviour such as money laundering and terrorist activities, help biologists understand key biological systems, and help engineers to understand large software systems.Read moreRead less