Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100074
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genet ....Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genetic and acquired disorders across the life-span. Remote viewing and analysis capabilities will help overcome the 'tyranny of distance', increasing national access to the facility. Repositories of digitised images will increase the availability of valuable research material to other Australian and international researchers.Read moreRead less
Subcellular recruitment of a RhoA ubiquitination complex by Rnd proteins. This study addresses a novel molecular mechanism through which members of the Rnd family of GTP-binding proteins regulate the morphology and migration of immature nerve cells of the developing nervous system. This study has broad implications for the understanding of cell migration during embryo development, as well as in health and disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989788
Funder
Australian Research Council
Funding Amount
$108,481.00
Summary
Nuclear Magnetic Resonance Microimaging and Relaxometry Facility. Many of the research projects to be supported by the facility are dedicated to improving our understanding of conditions and diseases that detrimentally affect many in our community. Projects investigating Alzheimer's disease, the central nervous system and its ability to repair, cancer and associated therapeutic treatments are some of the areas that will benefit from access to this equipment. The new facility will also provide un ....Nuclear Magnetic Resonance Microimaging and Relaxometry Facility. Many of the research projects to be supported by the facility are dedicated to improving our understanding of conditions and diseases that detrimentally affect many in our community. Projects investigating Alzheimer's disease, the central nervous system and its ability to repair, cancer and associated therapeutic treatments are some of the areas that will benefit from access to this equipment. The new facility will also provide unique insights into aspects of fundamental plant biology, with implications for improving crop productivity and better managing our natural ecosystems. The community will also benefit from the development and testing within the facility of new diagnostic tools and markers for a range of diseases.Read moreRead less
Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less