The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. This project will work with the Aboriginal Community to identify, evaluate and recommend an appropriate Competent Authority legal structure so Australia can meet the requirements of the Nagoya Protocol. This Protocol calls for a Competent Authority to govern and administer a legal framework that ensures Indigenous communities’ informed consent is obt ....Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. This project will work with the Aboriginal Community to identify, evaluate and recommend an appropriate Competent Authority legal structure so Australia can meet the requirements of the Nagoya Protocol. This Protocol calls for a Competent Authority to govern and administer a legal framework that ensures Indigenous communities’ informed consent is obtained for access to their traditional knowledge, and that establishes fair and equitable benefit-sharing mechanisms for use of that knowledge. This project will work with the Indigenous community to address concerns over the form, independence and funding of the Authority so Indigenous knowledge and culture can be protected and shared.Read moreRead less