Transcription At The Centromere: Roles In Formation, Maintenance And Function
Funder
National Health and Medical Research Council
Funding Amount
$549,092.00
Summary
Every human has 46 chromosomes. Chromosomes are structures that carry genes in all our cells. The centromere is an essential component of a chromosome which governs the process of cell division and separation of replicated chromosomes. Defects in centromere function cause abnormalities in cell division that in turn cause a variety of genetic diseases including cancer. We propose to investigate the role that transcription at the centromere plays in determining correct centromere function.