Ultra-sensitive 3D molecular assays using total body PET and deep learning. Recent advances in biomedical engineering have led to the development of Total Body Positron Emission Tomography (TB-PET), the most sensitive imaging device to date. Despite these impressive engineering advances, computational methods lag far behind and model-based approaches cannot deal with the complexity or volume of data these systems produce. We will develop new computational methods based on deep learning and stati ....Ultra-sensitive 3D molecular assays using total body PET and deep learning. Recent advances in biomedical engineering have led to the development of Total Body Positron Emission Tomography (TB-PET), the most sensitive imaging device to date. Despite these impressive engineering advances, computational methods lag far behind and model-based approaches cannot deal with the complexity or volume of data these systems produce. We will develop new computational methods based on deep learning and statistical methods that fully exploit the richness and complexity of the data generated by TB-PET, enabling 3D quantitative assays of molecular processes throughout the entire human body with unparalleled sensitivity. The technology we create will open up new capability for the study of complex physiological systems.Read moreRead less
A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on health ....A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on healthy spinal disc cells. We expect our technological framework to become an invaluable tool for biomedical engineers, biologists, and bio-engineers to work together and generate clinically relevant in-vitro data that supports optimisation for spinal implant design, fabrication, and safety. Read moreRead less