The Implementation And Evaluation Of Living Evidence In The Management Of Chronic Kidney Disease.
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Chronic kidney disease (CKD) is a growing health problem. Improving outcomes for patients with CKD requires the translation of research into clinical care. However, scientific research that underpins the management of CKD has rapidly increased, and traditional methods to summarise and inform clinical care are out of date. This project will develop, evaluate, and implement a new approach, known as ‘living-evidence’, that translates research evidence in real-time into the management of patients.
Improving Health Outcomes Of Preterm Newborns In Low- And Middle-income Countries
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Preterm birth (being born too soon) affects 1 in 10 births worldwide. In many low-income countries, preterm babies die for lack of effective care around the time of childbirth. My research aims to answer whether medicines such as steroid injections (to develop the baby’s lungs) and tocolytics (drugs to slow down or stop labour) actually help preterm babies born in low-income countries. I will also find ways to better measure how many women experience preterm birth in low-middle income countries.
Reducing The Burden Of Physical Inactivity And Excessive Sedentary Behaviour Through FIT (Feasible, Inclusive, Thorough) Guidelines
Funder
National Health and Medical Research Council
Funding Amount
$2,060,520.00
Summary
Public health guidelines concentrate on the least feasible (for the average adult) types of physical activity and place little emphasis on light intensity movement or sitting. My research program will inform future FIT (Feasible, Inclusive, Thorough) guidelines to assist policymakers, health professionals, and members of the public to improve healthy lifestyles in Australia.
Cancer is now the leading cause of death in our community. Dramatic progress in genomic technologies is impacting on cancer treatment and risk management internationally. My vision is an Australian Genomic Cancer Medicine Program (AGCMP), uniting than 15 cancer centres and three major medical research institutes in all states and territories, and bringing genomics through research into the clinic to improve health outcomes for all Australians.
Improving The Synthesis Of Medical Research: The Evidence Synthesis Taxonomy Initiative
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
People who make decisions regarding the health of individuals or a society need trustworthy information to support these decisions, whether they be about the effectiveness of a strategy, the burden of a disease, the accuracy of a medical investigation or the preferences and values of a population. To produce trustworthy evidence, we need to collate and synthesise all of the information available. This work will improve the science behind evidence synthesis and the quality of evidence synthesis.
Pathogenic Repeat Expansions In Ataxia: Advancing Gene Discovery And Genetic Diagnosis
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Hereditary ataxia is a severe neurological disorder that results in impaired coordination and balance and affects 1 in 20,000 Australians. Ataxias are often caused by complex genetic mutations called repeat expansions (RE), which are difficult to detect. Therefore, genetic diagnosis of ataxia remains limited and poorly accessible, leading to a gap in clinical care. In this study, we will utilise modern advances in genetic sequencing technology to diagnose and discover ataxias caused by REs.
Pain is a prevalent condition and a major cause of disease burden. The research program will address important questions in the clinical management of pain to reduce its the enormous burden. The program will: 1) investigate whether opioid medicines and oral steroids are effective in treating acute low back pain and neck pain, and sciatica, and 2) assess and improve the appropriate use of strong pain medicines in primary care.
Motor Impairment: Physiology, Pathophysiology And Intervention
Funder
National Health and Medical Research Council
Funding Amount
$2,814,215.00
Summary
It is very common to get Motor Impairments in many diseases and disorders, such as stroke and multiple sclerosis, and even with ageing. These affect our ability to move and function properly. I will use multidisciplinary expertise in basic, applied and clinical science to answer key questions about mechanisms and management of the Motor Impairments of weakness and fatigue, impaired sensation and balance, and muscle contracture. Results will be rapidly applied in clinical populations.
Overcoming The Barriers To Treatment Of Multi-drug Resistant Gram-negative Bloodstream Infections In Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$447,603.00
Summary
There is a critical need to develop new treatments for children with antibiotic resistant infections. The most important bacteria causing resistant infections are known as Gram-negative bacteria. Doctors treating children with resistant Gram-negative infections are faced with few antibiotic options. This project will discover the most important resistant infections in Australian children, and trial a new antibiotic to help doctors to use it in the right children and at the right dose.
Healthy Diet And Weight Management In Pregnancy: Evidence To Ease A Hefty Clinical Burden.
Funder
National Health and Medical Research Council
Funding Amount
$1,705,260.00
Summary
Approximately 50% of women are overweight or obese on entering pregnancy, placing women at increased risk of well documented pregnancy complications. This proposal will: 1) Translate RCT evidence into clinical practice to provide dietary advice for pregnant women 2) Address why pregnancy interventions have not impacted weight gain despite improved maternal diet 3) Consider the key features of an intervention before conception 4) Evaluate a pilot RCT weight loss intervention