Structural Studies On Human Glutamic Acid Decarboxylase
Funder
National Health and Medical Research Council
Funding Amount
$380,902.00
Summary
Mental health problems are a global issue and are subject to ongoing medical research. We study glutamic acid decarboxylase, a key enzyme responsible for the synthesis of a prominent and abundant neurotransmitter called GABA. GABA is crucial in controlling neuronal responses and facilitating new interconnections between neurones. Lacking GABA is related to epilepsy, Parkinson's disease, and post-traumatic stress. Our study is important for development of new ways to improve the supply of GABA in ....Mental health problems are a global issue and are subject to ongoing medical research. We study glutamic acid decarboxylase, a key enzyme responsible for the synthesis of a prominent and abundant neurotransmitter called GABA. GABA is crucial in controlling neuronal responses and facilitating new interconnections between neurones. Lacking GABA is related to epilepsy, Parkinson's disease, and post-traumatic stress. Our study is important for development of new ways to improve the supply of GABA in the brain.Read moreRead less
Central Neural Regulation Of Brown Fat Function – Glucose Sensing And CNS Pathways
Funder
National Health and Medical Research Council
Funding Amount
$761,942.00
Summary
Our research aims to identify how specific brain cells detect changes in glucose levels and how ageing and diet affect their function. We identified a subset of nerve cells that detect changes in glucose and the “hunger” hormone ghrelin, their ability to do so adapting with age and nutritional status. This project will investigate the potential of these nerve cells as targets for therapeutic and diet- intervention strategies to target obesity, diabetes and promote healthy ageing.
The Role Of Interferon Signalling In The Regulation Of Stroke
Funder
National Health and Medical Research Council
Funding Amount
$620,381.00
Summary
This project focuses on the role that inflammation plays in the progression of the type of neural injury seen in stroke victims. This project targets a specific pathway that is thought to be involved in the regulation of general inflammation but has not been greatly investigated in terms of the neural injury seen in stroke. Understanding the actions of this pathway may lead to future therapies that can be used to prime the brain to react in a positive way to stroke.
The Effect Of Smoking On The Exacerbation Of Stroke: Oxidative Stress Involvement And Cerebrovascular Response.
Funder
National Health and Medical Research Council
Funding Amount
$292,216.00
Summary
This grant addresses whether smoking contributes to the severity of stroke outcome. The studies outlined in this proposal will contribute significantly in our understanding of how smoking contributes to the progression of stroke. The understanding of the involvement of smoking in the progression of stroke will be of great benefit in the development of improved stroke patient management.