Preclinical Development Of A Therapeutic Anticancer Antibody To C-Met
Funder
National Health and Medical Research Council
Funding Amount
$435,530.00
Summary
Many common cancers cannot be effectively treated. A range of these cancers (e.g. gastric and lung cancer) display the molecule c-Met on their cell surface. c-Met promotes tumour growth; therefore, blocking c-Met is a promising strategy for treating these cancers. However, no antibodies or drugs that target c-Met have been licensed. The therapeutics that are being developed to target c-Met all have considerable limitations. Thus, there is an opportunity to develop a 'best-in-class' therapeutic.
Speech production in language-impaired speakers: Informing theoretical models and clinical practice regarding grammatical processing. This research examines how language is stored and processed in our minds and the ways this can go wrong. By improving our theory of language processing, the research will result in improved diagnosis and treatment for the ten per cent of Australians who suffer from communication impairment.
Goal pursuit decisions under environmental and social uncertainty. This project aims to develop an integrative computational model that explains how people prioritise the allocation of resources to different goals in the face of uncertainty. The project seeks to test a new theory through a series of experiments in which participants pursue goals by themselves in unpredictable environments, or in competition against an opponent. Expected outcomes include an integrated theory that accounts for the ....Goal pursuit decisions under environmental and social uncertainty. This project aims to develop an integrative computational model that explains how people prioritise the allocation of resources to different goals in the face of uncertainty. The project seeks to test a new theory through a series of experiments in which participants pursue goals by themselves in unpredictable environments, or in competition against an opponent. Expected outcomes include an integrated theory that accounts for the effects of both environmental and social uncertainty in the pursuit of multiple goals. Intended benefits include the development of computational models that can simulate human decision making in complex environments, analyse new concepts of operation, redesign work roles, and identify factors that reduce risk in decision-making.Read moreRead less
Using diagnostic tests in science as formative assessment to enhance teaching and learning. The success and continuation of science programs in upper secondary school and university is dependent on foundational improvements in science education in lower secondary schools. This proposal is designed to address this national concern by fostering talent in science and encouraging more students to study and enjoy science in a meaningful way. Through planned formative assessment, teachers will enable ....Using diagnostic tests in science as formative assessment to enhance teaching and learning. The success and continuation of science programs in upper secondary school and university is dependent on foundational improvements in science education in lower secondary schools. This proposal is designed to address this national concern by fostering talent in science and encouraging more students to study and enjoy science in a meaningful way. Through planned formative assessment, teachers will enable students in Years 8-10 to think about the science concepts and consider alternative explanations rather than memorise basic facts for a test or examination which are then forgotten. Practical benefits are a large range of valid and reliable tests and a range of teaching approaches for diagnosing student learning difficulties.Read moreRead less
Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demand ....Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demands when dealing with multiple stimuli or performing multiple tasks concurrently under time pressure. The project aims to provide the basic research that is needed to extend psychological models of choice to complex ‘real-world’ tasks, such air traffic control and maritime surveillance.Read moreRead less
Cognitive science: simulating the interactive evolution of human communication systems. We do not know how language first arose (the event left no trace), but it can be studied by simulating the circumstances under which new languages arise today. By having people play a game where they create new communication systems from scratch, this project will illuminate the origin of human language.
The Psychology of Misinformation—Towards A Theory-driven Understanding. The project aims to develop a psychological theory of misinformation effects. Misinformation influences people’s memory, reasoning and decision-making even after corrections – it thus poses a significant challenge for science and society. Through the combination of systematic experimentation with theory-driven computational modelling, the project will strive to concurrently consider individual-level cognition and the impact ....The Psychology of Misinformation—Towards A Theory-driven Understanding. The project aims to develop a psychological theory of misinformation effects. Misinformation influences people’s memory, reasoning and decision-making even after corrections – it thus poses a significant challenge for science and society. Through the combination of systematic experimentation with theory-driven computational modelling, the project will strive to concurrently consider individual-level cognition and the impact of sociocultural context. It is anticipated that this novel integrative approach will substantially expand our understanding of misinformation effects, and that this theoretical progress will result in the formulation of specific communication strategies to reduce the impact of misinformation on society.Read moreRead less
Developing a integrated memory-based model of evaluation and choice. People's judgements and choices are unstable. This project intends to examine one potential source of this instability: the memories that come to mind when people are evaluating choices. Many of the choices we make in our everyday lives are made on the basis of remembered information, and yet theories of evaluation and choice typically do not account for the role of memory, or provide only a cursory account of its role. In the ....Developing a integrated memory-based model of evaluation and choice. People's judgements and choices are unstable. This project intends to examine one potential source of this instability: the memories that come to mind when people are evaluating choices. Many of the choices we make in our everyday lives are made on the basis of remembered information, and yet theories of evaluation and choice typically do not account for the role of memory, or provide only a cursory account of its role. In the project, people will be presented with value information, and the project plans to examine how that information is retrieved from memory and then used to evaluate options and make decisions. Expected project outcomes would provide a coherent model that provides an integrated understanding of the role of memory in judgement and choice.Read moreRead less
The Impact Of Therapy On T-cell Recognition Of Mutated Tumour Neo-antigens
Funder
National Health and Medical Research Council
Funding Amount
$1,126,685.00
Summary
Cancer is caused by mutations which should be 'seen' and destroyed by the patients immune cells, similar to how immune cells protect us against viruses. But they don't. This grant will study how current cancer treatments help the immune cells 'see' these mutations. We will undertake these studies in the important cancers lung cancer and mesothelioma.
Creating a climate for change: from cognition to consensus. Climate change is a significant contemporary issue, and communicating the complexities of the terminology and the data is a major modern challenge. This project will apply principles of cognitive and social psychology to determine the most effective methods for promoting an understanding of the scientific dimensions of the issue. The research is significant because it provides a coherent theoretical framework for identifying the psychol ....Creating a climate for change: from cognition to consensus. Climate change is a significant contemporary issue, and communicating the complexities of the terminology and the data is a major modern challenge. This project will apply principles of cognitive and social psychology to determine the most effective methods for promoting an understanding of the scientific dimensions of the issue. The research is significant because it provides a coherent theoretical framework for identifying the psychological mechanisms underlying cognition and commitment at both an individual and collective level. The outcome will be a body of evidence that will inform strategies and policies for communication of complex scientific questions.Read moreRead less