Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental condition ....Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental conditions (especially exposure to steroid-like pollutants) is crucial to support breeding programs of endangered species and may improve veterinary and medicinal treatment of premature animals and humans. This multi-disciplinary, international collaboration provides an international training ground and two-way exchange of students and postdocs.Read moreRead less
Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine m ....Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine mammals. This study will significantly advance our knowledge of the diving physiology of Australian marine mammals. A detailed examination of the respiratory and surfactant systems of marine mammals may also reveal adaptations that enable these animals to endure sleep apnea and lung collapse.Read moreRead less
Scaling of structure, function and energetics of the vertebrate cardiovascular system. The hearts of mammals, reptiles and fish do different amounts of work, depending on the animal’s metabolic rate and body size. This project attempts to understand why hearts are the size and thickness that they are, and whether this results in minimising the work necessary to satisfy the requirements of the animal.
Global Security, Strategic Paradox and Limited War: The Politics and Ethics of Force. This project will provide detailed empirical research results plus conceptual innovations in the areas of peace and conflict studies. These will contribute to better understanding of contemporary threats and the effects of using force, and will enable the development of more effective policy options. The project will contribute strongly to the ARC's research priority 4, 'safeguarding Australia', by providing im ....Global Security, Strategic Paradox and Limited War: The Politics and Ethics of Force. This project will provide detailed empirical research results plus conceptual innovations in the areas of peace and conflict studies. These will contribute to better understanding of contemporary threats and the effects of using force, and will enable the development of more effective policy options. The project will contribute strongly to the ARC's research priority 4, 'safeguarding Australia', by providing important studies, analytical tools and policy recommendations that will strengthen Australia's national security, contribute to reducing conflict, and help us shape the regional and global security environment in our interests.Read moreRead less
Young people with cognitive disability: relationships and paid support. This project aims to improve the rights and wellbeing of young people with cognitive disability by exploring their relationship and interaction with paid support workers. The introduction of national individualised funding and support is a watershed in Australian disability policy. Understanding the role that paid support plays in the ongoing identity development of these young people is urgently needed to realise national p ....Young people with cognitive disability: relationships and paid support. This project aims to improve the rights and wellbeing of young people with cognitive disability by exploring their relationship and interaction with paid support workers. The introduction of national individualised funding and support is a watershed in Australian disability policy. Understanding the role that paid support plays in the ongoing identity development of these young people is urgently needed to realise national policy aspirations for people with disability of rights, choice, inclusion and independence. Using social geography and recognition theory, the project expects to deliver new understanding and improved practice around how paid support relationships can foster mutual care, respect and value at a critically important time in young people’s lives.Read moreRead less
What's bred in bone: effects of thyroid hormone supplementation on bone growth and remodelling in ectotherms and endotherms. Influence of resting metabolic rate (RMR) and exercise activity on bone microstructure is investigated in a variety of amniote taxa. By varying the dose of supplemental triiodothyronine (T3), ectotherms are made hyperthyroid with elevated RMR, and endotherms - hypothyroid with depressed RMR. Effects of T3 are compared against those of mechanical loading, in form of increa ....What's bred in bone: effects of thyroid hormone supplementation on bone growth and remodelling in ectotherms and endotherms. Influence of resting metabolic rate (RMR) and exercise activity on bone microstructure is investigated in a variety of amniote taxa. By varying the dose of supplemental triiodothyronine (T3), ectotherms are made hyperthyroid with elevated RMR, and endotherms - hypothyroid with depressed RMR. Effects of T3 are compared against those of mechanical loading, in form of increased daily treadmill exercise. Rates of bone growth and secondary remodelling are determined by histological analysis, and correlated with T3 and bone strain levels. The study tests the hypothesis that evolution of endothermy can be inferred from bone microstructure of fossil bones.Read moreRead less
Civilisationist Mobilisation, Digital Technologies and Social Cohesion. Civilisational populist rulers polarise societies mainly along religious lines. They also interfere with their emigrants, mobilising supporters against other expatriates. This project aims to advance knowledge of authoritarian states' transnational influence on social cohesion and inter-group conflict. By studying Islamist and Hindutva civilisationist mobilisations, their reach into their emigrants via digital technologies, ....Civilisationist Mobilisation, Digital Technologies and Social Cohesion. Civilisational populist rulers polarise societies mainly along religious lines. They also interfere with their emigrants, mobilising supporters against other expatriates. This project aims to advance knowledge of authoritarian states' transnational influence on social cohesion and inter-group conflict. By studying Islamist and Hindutva civilisationist mobilisations, their reach into their emigrants via digital technologies, and their impact on Turkish and Indian groups in Australia, the project aims to assist policy makers and community groups by generating conceptual frameworks, benchmarking data, and recommendations for making policies to deal with this phenomenon's negative effects and for developing intervention strategiesRead moreRead less
Design of the cardiovascular system of living and fossil vertebrates. This project aims to understand how the heart and blood vessels evolved in mammals, birds, reptiles and fish to achieve efficiency. The heart is the most important organ for life. The project will study the structure and function of vertebrate animals’ hollow and spongy hearts to show how energetics shaped their evolution. It will measure arterial holes in bone to gauge brain and bone metabolism, which opens up a new way to me ....Design of the cardiovascular system of living and fossil vertebrates. This project aims to understand how the heart and blood vessels evolved in mammals, birds, reptiles and fish to achieve efficiency. The heart is the most important organ for life. The project will study the structure and function of vertebrate animals’ hollow and spongy hearts to show how energetics shaped their evolution. It will measure arterial holes in bone to gauge brain and bone metabolism, which opens up a new way to measure metabolism in extinct animals directly from fossils, rather than by inference from living relatives. The expected outcome is to correlate cardiovascular design and metabolic rates of organs.Read moreRead less
Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and p ....Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and private sector organisations in Australia and New Zealand, the project intends to identify the factors that influence good and bad responses across a range of institutions; provide a clearer basis for reform of policies, procedures and law; and set benchmarks for comparative research worldwide.Read moreRead less
Cell-free immune reactions and suppression. Insects pests and insect vectors of diseases are managed by toxic substances, but insects have a cunning ability to persist. How pesticide-tolerant insect pests recognise and inactivate chemical and biological toxins is poorly understood. While vertebrates with a closed circulatory system use coagulation reactions mainly for wound-healing, invertebrates employ cell-free aggregation reactions for the sequestration and inactivation of potentially damagin ....Cell-free immune reactions and suppression. Insects pests and insect vectors of diseases are managed by toxic substances, but insects have a cunning ability to persist. How pesticide-tolerant insect pests recognise and inactivate chemical and biological toxins is poorly understood. While vertebrates with a closed circulatory system use coagulation reactions mainly for wound-healing, invertebrates employ cell-free aggregation reactions for the sequestration and inactivation of potentially damaging objects and substances. We use insect plasma to dissect recognition and inactivation of damaging objects and substances with the aim to understand tolerance and its inhibition to design novel strategies in delaying tolerance to pesticides in insect pests.Read moreRead less