Industrial Transformation Research Hubs - Grant ID: IH130200012
Funder
Australian Research Council
Funding Amount
$2,748,358.00
Summary
ARC Research Hub for Basin GEodyNamics and Evolution of SedImentary Systems (GENESIS). ARC Research Hub for Basin GEodyNamics and Evolution of SedImentary Systems (GENESIS). This Research Hub aims to undertake simultaneous modelling of deep Earth and surface processes, spanning basin scales to individual sediment grains. The Hub will develop and apply cutting-edge basin simulation approaches to transform the seeding and testing of basin exploration models, extending their viability to complex, ....ARC Research Hub for Basin GEodyNamics and Evolution of SedImentary Systems (GENESIS). ARC Research Hub for Basin GEodyNamics and Evolution of SedImentary Systems (GENESIS). This Research Hub aims to undertake simultaneous modelling of deep Earth and surface processes, spanning basin scales to individual sediment grains. The Hub will develop and apply cutting-edge basin simulation approaches to transform the seeding and testing of basin exploration models, extending their viability to complex, inaccessible remote and deep exploration targets. The Hub will fuse multidimensional data into five dimensional basin models (space and time, with uncertainty estimates) by coupling the evolution of mantle flow, crustal deformation, erosion and sedimentary processes, achieving a quantum leap in basin modelling and petroleum systems analysis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100058
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materi ....Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materials are often subjected to existing confining stresses. The full-field optical techniques, with an ultra-high speed and resolution camera in the system, aims to assist the quantitative measurement of deformation fields including small strain induced in brittle material's failure and identification of constitutive parameters.Read moreRead less
A study of high temperature transformation of oil shale - In-situ mineral reactions and structure analysis. In the current energy market, non-traditional fuels like oil shale are becoming more economically important. Australia has >33 billion tonnes of oil shales resources with potential for >1800 million tonnes of recoverable oil. This potential multi-billion dollar industry depends upon development of an efficient technology leading to economical oil production and much cleaner organic liquid ....A study of high temperature transformation of oil shale - In-situ mineral reactions and structure analysis. In the current energy market, non-traditional fuels like oil shale are becoming more economically important. Australia has >33 billion tonnes of oil shales resources with potential for >1800 million tonnes of recoverable oil. This potential multi-billion dollar industry depends upon development of an efficient technology leading to economical oil production and much cleaner organic liquid fuels. Retorting and combustion, which are core parts of oil shale conversion technology, would benefit from improved process conditions. This research proposal intends to investigate the in-situ complex oil shale thermal conversion reactions that occur during the retorting and combustion processes. Improved understanding of these complex reactions could lead to substantial economic and environmental improvements in oil shale processing.Read moreRead less
Low Temperature Catlytic Wet Oxidation of Organics from Strippped Sour Water. The commercialisation of a ~$3billion Australian oil shale industry heavily depends upon environmental sustainability of its technology. One key environmental issue of this technology is a need to remove organics from an aqueous industrial stream (stripped sour water). This proposal aims to develop a method based on catalytic wet oxidation for removing organics from stripped sour water. Research will be focused to deve ....Low Temperature Catlytic Wet Oxidation of Organics from Strippped Sour Water. The commercialisation of a ~$3billion Australian oil shale industry heavily depends upon environmental sustainability of its technology. One key environmental issue of this technology is a need to remove organics from an aqueous industrial stream (stripped sour water). This proposal aims to develop a method based on catalytic wet oxidation for removing organics from stripped sour water. Research will be focused to develop and study potential catalytic systems to lower the activation energy of the rate-determining step and to increase the rate of organics oxidation. The development of such a method would be a substantial technology achievement with many applications in pollution control for wastewater treatment in many other industries.Read moreRead less
Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Development Of Therapeutically Useful Human Artificial Chromosomes For Gene Delivery And Optimal Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$496,986.00
Summary
Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in ....Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in terms of infection, immune response, and germline modification. We have developed the first stage of a new technology for gene delivery that does not require the use of viruses. This technology is based on the generation of human artificial chromosomes, which are smaller versions of the naturally occurring chromosomes that carry all the genes inside our cells. Safety in these artificial chromosomes comes from the use of entirely human materials for their engineering. These artificial chromosomes also have other advantages over the viral approaches, including allowing large genes to be carried, and providing a permanent cure in a single treatment. We have already successfully constructed, published, and patented a number of first-generation human artificial chromosomes. The current project aims to complete the next proof-of-concept milestone towards the further development of this technology. Specifically, we propose to demonstrate the ability of the artificial chromosomes to carry genes and provide sustainable expression of these genes in cells and in animal models. Success in this study will allow the technology to proceed rapidly into commercialisation and clinical trial as a new improved tool for gene delivery and gene therapy.Read moreRead less
Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
An Integrated Approach For The Efffective Adoptive Immunotherapy Of Cancer
Funder
National Health and Medical Research Council
Funding Amount
$468,119.00
Summary
Killer T lymphocytes can penetrate tumors and their transfer into cancer patients has demonstrated some encouraging results, but this form of immunotherapy remain ineffective in most cancer patients. We propose to improve the tumor trafficking and anti-tumor activities of killer cells by genetically engineering them with proteins that will enable them to recognise and destroy cancer cells. The outcomes of this project will validate this novel approach for treatment of cancer patients.
The Role Of Transcriptional Co-activators And Co-repressors During Embryonic Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Every creature starts out as a single fertilized egg. The genome directs the embryonic development of the egg by regulating the expression of genes each of which must be turned on or off at the correct time and place. This essential balance between the activation or repression of genes is controlled by groups of proteins, including ‘transcriptional co-activators’ and ‘repressors’. This project aims to better understand the role of these proteins during embryonic development.