Central Blood Pressure And Cardiovascular Risk In Children Within The General Population And After Repair Of Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
With an exceptional research standing internationally, and as the leader of a Cardiovascular Bioengineering team, I am developing a new method for assessing central blood pressure in children that will provide better information about early risk of cardiovascular disease than arm blood pressure. This will be applied (1) in a large health study of Australian children and (2) to identify risks and causes of adult-type cardiovascular disease in children with repaired congenital heart disease.
The Role Of Non-coding RNAs In Development And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
We have discovered a new mechanism by which genome activity is regulated. This project will test the hypothesis that this mechanism is critical for cell growth and embryonic development. It has the potential to identify new causes of birth defects and may also be relevant to understanding the etiology of other diseases such as cancer, resulting in improvements in diagnosis and management of disorders that present a major health care burden.
Developing An Evidence Base For The Psychological Care Of Children And Families Affected By Congenital Heart Disease.
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Heart disease affects 1 in every 100 babies, making it one of the most common illnesses in infancy. Diagnosis and treatment of childhood heart disease often causes significant stress and trauma for children and their families. If support is not provided early, children can experience ongoing physical, emotional, and developmental problems. This program is built on a successful history of work and will improve child and family outcomes associated with heart disease through national and internatio ....Heart disease affects 1 in every 100 babies, making it one of the most common illnesses in infancy. Diagnosis and treatment of childhood heart disease often causes significant stress and trauma for children and their families. If support is not provided early, children can experience ongoing physical, emotional, and developmental problems. This program is built on a successful history of work and will improve child and family outcomes associated with heart disease through national and international research collaborations.Read moreRead less
The Role Of The Complement System In Neurodegeneration And The Therapeutic Potential Of Complement Inhibition
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
This project aims to identify the role of immune and inflammatory components in the pathology of neurodegenerative disease. Additionally, this research will determine whether a new class of novel anti-inflammatory drugs can alter the neurodegenerative process. This will allow for an increased understanding of the biology of neurodegenerative disease, and also may lead to the development of new treatments for conditions such as Parkinson’s disease, Huntington’s disease and motor neuron disease.
Investigatin The Causes Of Failed Efferocytosis In COPD-emphysema With A View To Identifying Novel Theraputic Targets
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
COPD is a leading cause of death. Smoking is the major cause of COPD and many sufferers are left with permanent damage and need ongoing treatment even after smoking cessation. Current treatments for COPD generally have limited efficacy. The project will identify the reason for the large number of dying cells and defective clearance of these cells that we have identified in the airways in COPD and study novel treatments that we hope will improve the health and well being of those with COPD.
Gene Discovery And Pathobiology In Muscle Diseases
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
I aim to find the genetic causes of muscle diseases that are lethal or severely debilitating. These diseases result in a significant burden to the affected individuals and their families and also on Australia’s Health care system. A genetic diagnosis provides families with answers, allows family planning, such that couples do not have another affected child, enables appropriate clinical management and gives researchers evidence as to how to develop treatments.