Ubiquitin And SUMO DNA Damage Response Signalling At Deprotected Telomeres During The Cell Cycle
Funder
National Health and Medical Research Council
Funding Amount
$302,627.00
Summary
Following genome damage cells stop the cell division process and initiate DNA repair. We discovered that at specific times during cell division his does not happen if the damage signals originate from the chromosome ends (i.e. “telomeres”). We anticipate this is necessary to prevent genomic instability in healthy cells and may be driving genomic instability in cancer cells. Experiments described here will elucidate the molecular mechanisms and biological significance of our observation.
Robust Data-Driven Control for Safety-Critical Systems. This project aims to develop new approaches to controlling robotic and cyber-physical systems in safety-critical applications. This project expects to generate new knowledge in how to harness the power of machine learning for robot control, while guaranteeing safety and stability at all times. The outcomes of this project will be new algorithms and a deeper understanding of the interplay of data, learning, and models, as well as experimenta ....Robust Data-Driven Control for Safety-Critical Systems. This project aims to develop new approaches to controlling robotic and cyber-physical systems in safety-critical applications. This project expects to generate new knowledge in how to harness the power of machine learning for robot control, while guaranteeing safety and stability at all times. The outcomes of this project will be new algorithms and a deeper understanding of the interplay of data, learning, and models, as well as experimental validation on a surgical robot and a bipedal walking robot. This project will provide significant benefits by dramatically increasing the range of applications in which the power of machine learning can be safely applied to advance the capabilities and uptake of robotics.Read moreRead less
Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater moni ....Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater monitoring. The intended outcomes are fundamental theories, effective control and learning algorithms for achieving highly-sensitive sensors. These outcomes should make important contributions to and deliver new knowledge and skills for Australia's sensing industries, which could benefit Australia's economic growth.Read moreRead less
Distributed Estimation, Control and Optimisation for Networked Systems. This project aims to study large scale networked systems in major infrastructures including power networks, transportation networks, internet of things, and other cyber-physical systems. This project is expected to develop new methodology and algorithms for distributed estimation, control and optimisation of these systems. Distributed solutions are essential because traditional techniques which were designed for small system ....Distributed Estimation, Control and Optimisation for Networked Systems. This project aims to study large scale networked systems in major infrastructures including power networks, transportation networks, internet of things, and other cyber-physical systems. This project is expected to develop new methodology and algorithms for distributed estimation, control and optimisation of these systems. Distributed solutions are essential because traditional techniques which were designed for small systems are not suitable for efficient operations of large scale systems. Application examples include distributed state estimation for power networks, control of multi-agent systems and optimal scheduling of transportation networks. The outcomes of this project are vital to the understanding and management of these systems. Read moreRead less
A New Approach to Sampled-Data Control Design for Nonlinear Systems. This project aims to exploit new sampling and sampled-data modelling insights to bridge the continuous/sampled-data gap in the control of nonlinear systems. The goal is to investigate the impact of these insights on the control design problem and provide a new class of digital control laws for continuous time non-linear systems.
Robust control of power electronics and drives: a synthesis of traditional and model predictive control approaches. This project aims to generate high-performance strategies for the control of power converters. Through the combination of traditional and modern approaches, the project will develop methods which are more reliable and give better energy efficiency than current state of the art techniques.
Robust control of mobile networked systems. The conceptual advances with new design rules are to be developed in the area of robust control of mobile networked systems. A major benefit of the research to be carried out in this project will be its direct application to industrial control problems in the defence, communications and robotics industries and to the management of the environment.
Efficient and high-precision system identification in quantum cybernetics. This project aims to develop new theories and algorithms to enhance system identification capabilities in quantum cybernetics from the perspective of systems and control. The project is anticipated to advance key knowledge and provide effective methods to enable identification of microsystems for wide applications arising in this emerging technology revolution. The intended outcomes are fundamental theories, and efficient ....Efficient and high-precision system identification in quantum cybernetics. This project aims to develop new theories and algorithms to enhance system identification capabilities in quantum cybernetics from the perspective of systems and control. The project is anticipated to advance key knowledge and provide effective methods to enable identification of microsystems for wide applications arising in this emerging technology revolution. The intended outcomes are fundamental theories, and efficient estimation methods for identifying these systems. This project will make important contributions to accelerating practical applications of new technology, and deliver new knowledge and skills for Australia's future industries, which will benefit Australia's economic growth.Read moreRead less
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Exploring new tools in nonlinear filtering and control. The conceptual advances with new design rules to be developed in the area of nonlinear filtering and control. Major benefits of this project will be its direct applications to state estimation and control problems in automobile, manufacturing, military hardware and medical device industries, and its increased capacity of contact research.