The Role Of Presenilin In Metal Homeostasis And Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,335.00
Summary
Presenilin, a protein involved in Alzheimer’s disease (AD), may regulate copper and zinc levels. Copper and zinc are essential nutrients however a deficiency or excess can cause disease. Promising metal-altering AD drugs, are in various stages of clinical trial. I aim to characterize the interaction of Presenilin and metals using both mouse and cultured human cell models that are deficient in Presenilin. Understanding this interaction should lead to better drug design and treatment of AD.
Gastrokine 2 Promotes Gastric Homeostasis And Inhibits Bacterial Pathology
Funder
National Health and Medical Research Council
Funding Amount
$621,335.00
Summary
Gastrokine 2 is a small regulatory protein secreted by the stomach lining. Its function is unknown but data from our lab suggests that it may be important in maintaining stomach integrity. This project will investigate how gastrokine 2 maintains stomach function, how this can be compromised when bacterial infection is ongoing, and how we might be able to turn up gastrokine 2 expression to prevent inflammation and precancerous changes in the stomach lining.
Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by ....Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by chemical reactions to the slag phase. The outcomes are intended to enable copper smelters to maximise direct copper recovery, reduce copper production costs and increase the productivity of the smelting process.Read moreRead less
Sustainable copper metallurgy and recycling – saving energy and resources. This project aims to develop new, powerful and sophisticated, computer-based models that can reliably predict the results of chemical reactions in complex, high temperature metal production processes. This project expects to use these models, initially applied to copper smelting systems, to enable the improved recycling of other valuable metals. These models should be able to be applied to a wide range of technologies use ....Sustainable copper metallurgy and recycling – saving energy and resources. This project aims to develop new, powerful and sophisticated, computer-based models that can reliably predict the results of chemical reactions in complex, high temperature metal production processes. This project expects to use these models, initially applied to copper smelting systems, to enable the improved recycling of other valuable metals. These models should be able to be applied to a wide range of technologies used in the metallurgical industry as most of the world’s metals are produced by these pyrometallurgical processes. This should provide significant benefits such as substantial improvements in productivity and process efficiencies, whilst at the same time delivering energy savings and improved use of valuable metal resources.Read moreRead less
Creating wealth from new resources - High temperature extraction of metals from complex copper ores and recycled materials. Most of the world’s copper is produced using high temperature chemical processing (smelting). Both primary ores and recycled raw materials contain valuable elements and also potentially harmful impurity elements. To unlock and utilise current and new resources, and also minimise the environmental impacts the industry has identified the need for new fundamental scientific da ....Creating wealth from new resources - High temperature extraction of metals from complex copper ores and recycled materials. Most of the world’s copper is produced using high temperature chemical processing (smelting). Both primary ores and recycled raw materials contain valuable elements and also potentially harmful impurity elements. To unlock and utilise current and new resources, and also minimise the environmental impacts the industry has identified the need for new fundamental scientific data that describe the chemical behaviour of impurity elements in these systems. The project aims to then use the data to develop powerful computer-based thermodynamic models that can predict the products of complex industrial processes. These sophisticated tools are intended to then be used to improve the performance of existing industrial operations and assist in the development of new process designs.Read moreRead less
Rapid approximate imaging of electromagnetic data acquired using multichannel distributed acquisition systems. This project will investigate techniques for rapid, multidimensiuonal imaging of electromagnetic data acquired using modern multichannel distributed acquisition systems. This research will provide high-resolution images of buried ore deposits at greater depths than is possible using current instruments and processing techniques.
The Cell Death Mechanisms That Control Regulatory T Cell Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$583,782.00
Summary
A central question in immunology is how to prevent destructive immune responses (e.g. autoimmune disease) and initiate productive immune responses (e.g. against cancer). A major breakthrough in this area was the discovery of special immune cells, called a Regulatory T Cells. We propose to discover the genes that determine whether these cells live and die. We will use this information to control appropriate numbers and function of Regulatory T Cells to modify the immune system.
Finding Porphyry Copper with zircon trace elements & hyperspectral display. Copper mine discovery rates lag behind world needs. One way to find copper in the World’s Ring of Fire is to measure compositions of zircons which are durable minerals concentrated in stream sands and spreadout long distances below a deposit. 100s of zircon from a cup of sand constitute a sample. Zircon chemical features that indicate possible mines are mostly understood, but nature is complicated. Beyond the 26 channel ....Finding Porphyry Copper with zircon trace elements & hyperspectral display. Copper mine discovery rates lag behind world needs. One way to find copper in the World’s Ring of Fire is to measure compositions of zircons which are durable minerals concentrated in stream sands and spreadout long distances below a deposit. 100s of zircon from a cup of sand constitute a sample. Zircon chemical features that indicate possible mines are mostly understood, but nature is complicated. Beyond the 26 channels of chemical data for each grain in the 10,000s of analyses, there are 7 layers of lab imaging data that are not carried along in a convenient way. Geologists need smart computer systems to find useful relationships among the 33 channels and to discover relations within and between samples to find more mineable copper. Read moreRead less
The Role Of Copper In Ubiquitin-dependent Protein Degradation In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$588,622.00
Summary
Ubiquitin’s are small proteins that tag other proteins in a process known as “Ubiquitination”. Often this is to target them for degradation once they are no longer needed i.e. to take out the rubbish. This process is disrupted in Alzheimer’s disease (AD), which may contribute to the disease. This project aims to find out if copper, an essential metal for life, is required for this process. Drugs that are designed to deliver copper to brain cells have been effective in small AD clinical trials.
The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and ....The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and legislative motivation for reducing fuel emissions, the development of new Mg-based alloys capable of meeting this demand from automotive manufacturers represents both a potentially large economic advantage to the country of development as well as helping to address the environmental concern about fuel emissions.Read moreRead less