Structural And Functional Characterisation Of Human Neurotransmitter Inhibitor Producing Enzymes Glutamate Decarboxylase
Funder
National Health and Medical Research Council
Funding Amount
$35,085.00
Summary
Glutamate decarboxylase (GAD) produces the major inhibitory neurotransmitter in the central nervous system, GABA. GAD dysfunction is associated with mental diseases including epilepsy and schizophrenia. We aim to understand the functional role of structural elements of GAD via x-ray crystallography and kinetic studies. We also aim to produce a high throughput GAD enzyme assay to screen compounds that can modulate GAD activity, which could be potential therapeutic targets for related disease.
Structural Characterisation Of Peptide Bound HLA-DQ2, HLA-DQ8, And Their Specific T Cell Receptors In Celiac Disease
Funder
National Health and Medical Research Council
Funding Amount
$33,626.00
Summary
Celiac disease is an inflammatory condition resulting from an inappropriate immune response to dietary gluten, present in cereals such as wheat, rye and barley. In affected individuals, ingestion of gluten can result in bloating, chronic diarrhoea, and malabsorption. At present, the only treatment is strict adherence to a gluten free diet. This project will investigate the immune response to gluten on a molecular level, aiding in the development of new treatments(e.g. non-toxic wheat varieties).