Pharmacological Development Of Synthetic Analogues Of Cytochrome P450-mediated Omega-3 Fatty Acid Epoxides As Novel Anti-metastatic Agents
Funder
National Health and Medical Research Council
Funding Amount
$865,174.00
Summary
Dietary ?-3 and ?-6 fatty acids respectively decrease and increase the risk of cancer spread, or metastasis. We have found that ?-3 fatty acid epoxide metabolites inhibit the growth and migration of tumour cells. We have prepared derivatives of these ?-3 epoxides that retain anti-cancer properties in cells. In this project we will develop analogues of these ?-3 epoxides that are suitable for in vivo testing in animal models of breast cancer metastasis as a new class of potential anti-metastatic ....Dietary ?-3 and ?-6 fatty acids respectively decrease and increase the risk of cancer spread, or metastasis. We have found that ?-3 fatty acid epoxide metabolites inhibit the growth and migration of tumour cells. We have prepared derivatives of these ?-3 epoxides that retain anti-cancer properties in cells. In this project we will develop analogues of these ?-3 epoxides that are suitable for in vivo testing in animal models of breast cancer metastasis as a new class of potential anti-metastatic drugs.Read moreRead less
Development Of Novel Anti-cancer Agents Based On Cytochrome P450-mediated Epoxides Of Omega-3 Fatty Acids
Funder
National Health and Medical Research Council
Funding Amount
$949,433.00
Summary
There are few effective treatments for advanced breast cancer. Dietary ?-3 and ?-6 fatty acids respectively decrease and increase the risk of cancer spread. We have found that ?-3 fatty acid epoxide metabolites inhibit the growth of tumour cells and have prepared analogues that are highly active in vivo in animal models of breast cancer. This project will improve and optimise these agents that hold promise as a new class of anti-cancer drugs with the potential to treat advanced disease.