Testosterone Intervention For The Prevention Of Diabetes Mellitus In High Risk Men: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$5,054,654.00
Summary
Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a l ....Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a lifestyle program.Read moreRead less
How are visual gene pathways lost and restored during reptile evolution? This project aims to investigate how complex traits are lost during evolution, and once lost if they can be regained. The project will use the diverse visual systems of snakes and lizards to shed light on the process of gene loss in degenerative lineages, and discover the mechanisms that compensate for gene losses in taxa with secondarily evolved visual capabilities- providing a case of evolutionary re-innovation in complex ....How are visual gene pathways lost and restored during reptile evolution? This project aims to investigate how complex traits are lost during evolution, and once lost if they can be regained. The project will use the diverse visual systems of snakes and lizards to shed light on the process of gene loss in degenerative lineages, and discover the mechanisms that compensate for gene losses in taxa with secondarily evolved visual capabilities- providing a case of evolutionary re-innovation in complex traits.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100177
Funder
Australian Research Council
Funding Amount
$290,000.00
Summary
A regional optical dating facility in Australia. This project aims to establish an open access, end-user friendly optical dating facility in Australia. This will address shortcomings in the capacity and geographical coverage of the existing national geochronology infrastructure and enable Australian researchers to reconstruct past records of climate change, human evolution, ecological vulnerabilities, natural and man-made hazards and environmental disturbance over historical to near-million-year ....A regional optical dating facility in Australia. This project aims to establish an open access, end-user friendly optical dating facility in Australia. This will address shortcomings in the capacity and geographical coverage of the existing national geochronology infrastructure and enable Australian researchers to reconstruct past records of climate change, human evolution, ecological vulnerabilities, natural and man-made hazards and environmental disturbance over historical to near-million-year timeframes. This project is expected to increase commercial demand for geoscience services and lead to better understanding of Australia’s natural heritage and its long-term vulnerabilities.Read moreRead less
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples' social networks that occur with age, and the effects of these changes on health and well being in later life. The project will use information collected from several ongoing Australian studies of ageing, and will have important implications for social policy in Australia.
ARC Centre of Excellence for the Elimination of Violence Against Women. ARC Centre of Excellence for the Elimination of Violence Against Women. Eliminating violence against women is one of the major challenges of the 21st century. Awareness of the problem has grown exponentially, but solutions to it have not. This Centre aims to transform our understanding of the problem by examining the structural drivers that cause and compound violence against women, and pioneering new, evidence-based approac ....ARC Centre of Excellence for the Elimination of Violence Against Women. ARC Centre of Excellence for the Elimination of Violence Against Women. Eliminating violence against women is one of the major challenges of the 21st century. Awareness of the problem has grown exponentially, but solutions to it have not. This Centre aims to transform our understanding of the problem by examining the structural drivers that cause and compound violence against women, and pioneering new, evidence-based approaches to radically improve policy and practice across Australia and the Indo-Pacific. The Centre mobilises survivor-centric and Indigenous methodologies, interdisciplinary collaborations, and Indo-Pacific partnerships to deliver scalable approaches to eliminate violence against women across the legal, security, economic, health, and political systems of Australia and the region.Read moreRead less
Integrating models with molecular 'logbooks' to better forecast extinction risk from climate change. Current forecasts indicate that human-driven climate change will likely cause widespread biodiversity loss. However, climatic shifts during the Quaternary (2.6 million years ago to present), similar in magnitude to those projected for the 21st century, did not apparently cause extensive extinctions (with the exception of the megafauna). This project aims to use models linked to past responses imp ....Integrating models with molecular 'logbooks' to better forecast extinction risk from climate change. Current forecasts indicate that human-driven climate change will likely cause widespread biodiversity loss. However, climatic shifts during the Quaternary (2.6 million years ago to present), similar in magnitude to those projected for the 21st century, did not apparently cause extensive extinctions (with the exception of the megafauna). This project aims to use models linked to past responses imprinted in species’ genes to resolve whether the disparity between observed and predicted extinction rates comes from models over-predicting species loss due to climate change. It will use this genetic-demographic approach to improve predictions of biodiversity responses to global change by establishing the biological and environmental determinants of extinction.Read moreRead less
Naracoorte caves: a critical window on faunal extinctions and past climates. This project aims to establish an unprecedented record of biodiversity and environmental change at Australia’s richest Quaternary fossil site – Naracoorte Caves. The study will integrate all aspects of the preserved deposits, employing new approaches in geochronology, palaeontology and geochemistry to develop truly comprehensive palaeoecological and palaeoclimate histories. This project will establish a benchmark datase ....Naracoorte caves: a critical window on faunal extinctions and past climates. This project aims to establish an unprecedented record of biodiversity and environmental change at Australia’s richest Quaternary fossil site – Naracoorte Caves. The study will integrate all aspects of the preserved deposits, employing new approaches in geochronology, palaeontology and geochemistry to develop truly comprehensive palaeoecological and palaeoclimate histories. This project will establish a benchmark dataset on past ecological and environmental change, strengthening scientific innovation in key research priority areas. It will have significant implications for understanding megafauna extinctions and past biodiversity responses, and will inform future conservation and climate change adaptation strategies. The project will transform the scientific profile of Naracoorte Caves, ensuring socioeconomic benefits to regional communities through education, ecotourism and knowledge marketing.Read moreRead less
Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si a ....Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si alleviates stress in wheat, from gene to farm scale, providing cost-benefit analysis and a best–practice toolbox for implementation by farmers. Outcomes are anticipated to provide a cheaper and more environmentally sustainable solution to issues of water scarcity and yield losses to pests in Australia’s leading crop.Read moreRead less
Social Capital, Natural Resources and Local Governance in Indonesia. Australia's relationship with Indonesia is critical to our political and environmental security. This proposed research addresses the need for more effective development assistance policy, and will broaden public understanding of Indonesia's urgent social and environmental issues. International collaboration among an experienced team of field researchers, working with government agencies and NGOs, will enhance the capacity of I ....Social Capital, Natural Resources and Local Governance in Indonesia. Australia's relationship with Indonesia is critical to our political and environmental security. This proposed research addresses the need for more effective development assistance policy, and will broaden public understanding of Indonesia's urgent social and environmental issues. International collaboration among an experienced team of field researchers, working with government agencies and NGOs, will enhance the capacity of Indonesian communities to achieve more sustainable and equitable outcomes, contributing to regional security. Social capital questions concerning local capacity building and public engagement in decision-making also have comparative importance for the role of civil society and NGOs in Australian public policy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100624
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
The role of epigenetic modifications in tiger snake adaptation. This project aims to investigate mechanisms underlying animal adaptation to future environmental change by examining the molecular basis for phenotypic plasticity in snakes. This project will specifically examine variation in genetic/epigenetic profiles and compare against important fitness traits, such as variable head size, bite force and swallowing performance to identify relationships between molecular change and physiology. Suc ....The role of epigenetic modifications in tiger snake adaptation. This project aims to investigate mechanisms underlying animal adaptation to future environmental change by examining the molecular basis for phenotypic plasticity in snakes. This project will specifically examine variation in genetic/epigenetic profiles and compare against important fitness traits, such as variable head size, bite force and swallowing performance to identify relationships between molecular change and physiology. Such research is a critical first step in improving our knowledge of the mechanisms whereby animal populations may adapt to environmental change, allowing us to facilitate such processes or concentrate conservation effort where species are unable to adapt via epigenetic modification.Read moreRead less