Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which i ....Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved quality of life.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100146
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Multiphoton confocal microscope for high-speed, deep tissue imaging and multimodal nanoscale characterisation. This facility will provide the ability to optically section deep nanoparticles, cells, tissues and whole animals at high speed with unsurpassed spatial resolution at the atomic level. It will give biomedical, physical and life scientists and materials engineers the opportunity to image a range of dynamic processes and reconstruct these in three dimensions for the first time.
Discovery Early Career Researcher Award - Grant ID: DE210100858
Funder
Australian Research Council
Funding Amount
$344,896.00
Summary
Human-Centred Robot Training. This project aims to address the challenge of effectively enabling novice users to train robots on complex tasks using instructional methods and gamification. With the recent advances of AI research, robots have now better cognitive and functional skills, research in robot training also now allows them to learn interactively from human. Since these robots are expected to provide assistance in different domains including education and healthcare, it is crucial to eff ....Human-Centred Robot Training. This project aims to address the challenge of effectively enabling novice users to train robots on complex tasks using instructional methods and gamification. With the recent advances of AI research, robots have now better cognitive and functional skills, research in robot training also now allows them to learn interactively from human. Since these robots are expected to provide assistance in different domains including education and healthcare, it is crucial to effectively engage human in robot’s instruction. Expected outcomes include new methods for trainers to assess robot learning, and to improve their engagement and feedback. This should provide significant human-robot interaction benefits for accessibility of learning robots.Read moreRead less
Making eMaking Accessible for People with Intellectual Disabilities. This interdisciplinary research will create an evidence based eMaking program that empowers people with Intellectual Disabilities. eMaking benefits include collaborative problem solving and employment pathways; however, people with disabilities are often excluded. Through a unique, inclusive, outreach van, strategies to build accessible eMaking will be generated. Project outcomes include replicable, scalable eMaking activities ....Making eMaking Accessible for People with Intellectual Disabilities. This interdisciplinary research will create an evidence based eMaking program that empowers people with Intellectual Disabilities. eMaking benefits include collaborative problem solving and employment pathways; however, people with disabilities are often excluded. Through a unique, inclusive, outreach van, strategies to build accessible eMaking will be generated. Project outcomes include replicable, scalable eMaking activities and toolkits to facilitate Science, Technology, Engineering and Mathematics for all. Project benefits include opportunities for people with Intellectual Disability to participate in meaningful recreational or work-focused eMaking, and changing community attitudes through shared eMaking participation.Read moreRead less
Improving the face of cosmetic medicine - an automatic three-dimensional facial analysis system for facial rejuvenation. 'How will I look?' is the most common question to cosmetic doctors from patients considering facial rejuvenation. This project will answer this question for the first time by providing patients with a three-dimensional model of their post-treatment face as well as informing cosmetic doctors exactly how to achieve the patient's desired face.
Machine Learning for Fracture Risk Assessment from Simple Radiography. This project aims to develop a novel, reliable, low-cost system to detect poor bone health and assess fracture risk to help to prevent and manage osteoporosis-related fractures. Currently, osteoporosis-related fractures cost our health system millions of dollars annually and costs are increasing with our ageing population. Early detection of poor bone health will improve the effectiveness of preventive measures and ease this ....Machine Learning for Fracture Risk Assessment from Simple Radiography. This project aims to develop a novel, reliable, low-cost system to detect poor bone health and assess fracture risk to help to prevent and manage osteoporosis-related fractures. Currently, osteoporosis-related fractures cost our health system millions of dollars annually and costs are increasing with our ageing population. Early detection of poor bone health will improve the effectiveness of preventive measures and ease this burden. Current methods include unreliable, crude clinical and visual guides that suggest osteoporosis screening. The project plans to develop a novel system by applying machine learning algorithms to radiology data which is commonly captured for diagnosing other conditions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100234
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Enhancement of South Australian high-performance computing facilities. These facilities will enable the efficient use of high-performance computing and will more than double the capability provided by eResearch SA for South Australian researchers. They will support large-scale applications, running over many processors in parallel (high-performance computing) or large numbers of single processors (high-throughput computing).
Discovery Early Career Researcher Award - Grant ID: DE160100715
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Tunable plasmonics in ultra-doped transition metal oxides and chalcogenides. The project is designed to explore new classes of plasmonic materials based on low-dimensional transition metal oxide and chalcogenide nanostructures. These crystals, with stratified structures and high surface affinities to charged particles, present a new frontier in plasmonics by allowing reversible stimuli induced doping and defect embedding. The project plans to focus on achieving tunable plasmonic properties acros ....Tunable plasmonics in ultra-doped transition metal oxides and chalcogenides. The project is designed to explore new classes of plasmonic materials based on low-dimensional transition metal oxide and chalcogenide nanostructures. These crystals, with stratified structures and high surface affinities to charged particles, present a new frontier in plasmonics by allowing reversible stimuli induced doping and defect embedding. The project plans to focus on achieving tunable plasmonic properties across a broad spectrum from ultraviolet to infrared light. Targets are systems with low propagation losses or ultra-sensitivity towards environmental changes. The anticipated outcomes will serve as a base to establish the next generation plasmonic communication and sensing systems with active on-chip controllability, which could be used as the base of future telecommunications, energy harvesting and sensing systems.Read moreRead less
Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100119
Funder
Australian Research Council
Funding Amount
$424,607.00
Summary
Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughpu ....Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughput drug screening and preparing cells for implantation therapy. Significant benefits for end users in pharmaceutical industry, life sciences research and hospitals are expected from the project and the application of the developed technology.Read moreRead less