Drugging the undruggable: Development of novel technologies to selectively regulate the expression of targets driving cancer and other diseases. Transcription factors are “undruggable” targets playing a principal role driving cancer. This project will create novel therapeutic strategies to inhibit transcription factors and other elusive targets differentially expressed in diseased cells, without affecting normal tissue. It proposes to construct engineered proteins able to bind and modify specifi ....Drugging the undruggable: Development of novel technologies to selectively regulate the expression of targets driving cancer and other diseases. Transcription factors are “undruggable” targets playing a principal role driving cancer. This project will create novel therapeutic strategies to inhibit transcription factors and other elusive targets differentially expressed in diseased cells, without affecting normal tissue. It proposes to construct engineered proteins able to bind and modify specific key genes deregulated in cancer, to correct their expression and stably reprogram the phenotype of the tumour cell in a normal-like state. It outlines the engineering of novel synthetic agents to block specific protein-protein interactions in cancer cells and to induce potent tumour cell death. This work will generate novel and selective therapeutics to treat un-curable forms of tumours.Read moreRead less
Theoretical modelling of the interaction of THz with hydrated materials. Terahertz (THz) technology is in use in diverse applications from security screening to biomedical imaging. A critical hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and hydrated materials. The aim of this project is to develop new mathematical and computer models for exploring the interaction of THz radiation with different materials. These model ....Theoretical modelling of the interaction of THz with hydrated materials. Terahertz (THz) technology is in use in diverse applications from security screening to biomedical imaging. A critical hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and hydrated materials. The aim of this project is to develop new mathematical and computer models for exploring the interaction of THz radiation with different materials. These models aim to create a platform for the future development of THz technology and applications, and are expected to lead to accelerated implementation for use in biology and protein analysis; pharmaceutical sciences, formulations and medicine; and burn assessment and cancer detection.Read moreRead less