Breast CAncer STratification: Understanding The Determinants Of Risk And Prognosis Of Molecular Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$472,984.00
Summary
Breast cancer is not one disease, but many different types with different causes, treatments and outcomes. The aim of this project is to use genetic, lifestyle/environmental, mammographic breast density, pathologic and clinical data froma very large number of studies from all over the world to develop ways of predicting which women are at risk of particuar types of breast cancer, and if breast cancer develops what the likely outcome will be.
Early Detection Of Alzheimer's Disease Using Ocular Biomarkers
Funder
National Health and Medical Research Council
Funding Amount
$602,502.00
Summary
Curcumin fluorescence imaging of the retina will be tested for quantification of retinal amyloid plaque burden and rate of change. This will be compared to AD disease status, brain plaque burden and other markers to evaluate retinal imaging as an early test for AD.
What Can Tau Deposition Tell Us About The Appearance Of Subjective And Objective Cognitive Decline In Older Adults?
Funder
National Health and Medical Research Council
Funding Amount
$674,077.00
Summary
Subjective memory concerns are common in older adults, but it is uncertain how they relate to Alzheimer’s disease (AD) biomarkers. Novel neuroimaging techniques have been developed for measuring tau deposition, a hallmark feature of AD. Using this technique, I aim to determine whether tau is sensitive to certain types of subjective concerns. My findings will reveal which concerns are indicative of AD risk, and which arise from unrelated factors, such as inattention or stress.
Dementia is an urgent global challenge with enormous health and economic cost to Australia. While the hope is for a cure, the number with dementia is growing and diagnosis is often delayed by ~3 years. This project will use innovative neurocognitive methods to achieve earlier diagnosis and develop tailored treatments. This will enhance or maintain function, promoting independence and community living, improving the quality of life and care for persons living with dementia.
Breast Cancer Risk After Diagnostic Gene Sequencing (BRIDGES)
Funder
National Health and Medical Research Council
Funding Amount
$471,281.00
Summary
In BRIDGES, we aim to build a knowledge base to better define individual breast cancer risk. We bring together, in a multidisciplinary team, data and expertise from clinical genetics, epidemiology, bioinformatics, statistics, and gene biology. Specifically, we will use state-of-the art DNA screening to evaluate all suspected breast cancer genes in a large sample of breast cancer cases and controls. We will then use in silico and in vitro functional analyses to evaluate the likely pathogenicity o
Early Detection Of Lung Cancer And Mesothelioma In Asbestos Workers At Highest Risk
Funder
National Health and Medical Research Council
Funding Amount
$623,268.00
Summary
Through no fault of their own, many Australian workers have been inadvertently exposed to asbestos and are at high risk of developing lung cancer and mesothelioma. With the peak incidence bearing upon us, there is an urgent need for early detection by CT.
Application Of Omics-based Strategies For Improved Diagnosis And Treatment Of Endocrine Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$461,322.00
Summary
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. We will define specific omics profiles for patients with a range of hypertension-related disorders by integrating high throughput genetics, genomics and metabolomics data. This should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.
Nutrition And Rehabilitation In Advanced Cancer Patients
Funder
National Health and Medical Research Council
Funding Amount
$225,991.00
Summary
This preliminary project aims to evaluate associations between cancer cachexia, psychosocial factors and cytokine levels in blood. The final decline of most patients with advanced cancer is associated with the cancer cachexia syndrome, triggered in part by cytokine release. Measuring cytokines may enable identification of patients about to enter this final stage. Further, factors like mood and social support appear to alter cytokine levels. The associations established by this study may point to ....This preliminary project aims to evaluate associations between cancer cachexia, psychosocial factors and cytokine levels in blood. The final decline of most patients with advanced cancer is associated with the cancer cachexia syndrome, triggered in part by cytokine release. Measuring cytokines may enable identification of patients about to enter this final stage. Further, factors like mood and social support appear to alter cytokine levels. The associations established by this study may point to treatment options that can delay the terminal phase while improving quality of life.Read moreRead less
Patterns Of Cancer Care For Indigenous People In NSW
Funder
National Health and Medical Research Council
Funding Amount
$1,690,636.00
Summary
Cancer is the second biggest killer of Indigenous Australians: for some cancers the mortality rate is more than 3 times higher in Aboriginal people and overall it is 60% higher. While differences in stage at diagnosis and the type and duration of care received by Aboriginal people may contribute to the higher mortality, this has not been studied in detail. New South Wales has the largest Aboriginal population in Australia. Reliable and current data on cancer care for NSW Aboriginal people will a ....Cancer is the second biggest killer of Indigenous Australians: for some cancers the mortality rate is more than 3 times higher in Aboriginal people and overall it is 60% higher. While differences in stage at diagnosis and the type and duration of care received by Aboriginal people may contribute to the higher mortality, this has not been studied in detail. New South Wales has the largest Aboriginal population in Australia. Reliable and current data on cancer care for NSW Aboriginal people will allow health services to better target cancer care. The aims of this project are: to determine whether Aboriginal people are being diagnosed with cancer at later stages; to describe the barriers to Aboriginal people being diagnosed earlier and accessing cancer care; to describe the care that Aboriginal people with cancer are currently receiving; and to compare their level and types of care with that received by non-Indigenous people. We will conduct four studies to address these aims. We will conduct interviews with Aboriginal people diagnosed with cancer and Aboriginal health workers who look after people with cancer to find out about their perceptions and experiences of Aboriginal people dealing with cancer. We will analyse a data set containing records from the NSW Central Cancer Registry and hospital admission records for people living in NSW. Treatments for cancer for Aboriginal and non-Indigenous people will be compared. This analysis will be complemented by an examination of records at Aboriginal Medical Services to obtain information on other treatments such as chemotherapy and radiotherapy and referrals to specialists. We will also conduct a population-based patterns of care study where questionnaires seeking information about the diagnostic tests performed and types of treatment given will be sent to doctors who have treated Aboriginal people with cancer. In addition, information will be obtained from Aboriginal people with newly diagnosed cancer about the clinical pathway that led to the diagnosis.Read moreRead less