Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
Adolescents becoming delinquent online. The project aims to provide a longitudinal criminological study of adolescent Internet use in the world. The Internet is a pervasive influence in young people's lives and is increasingly viewed as a significant factor in the incidence of criminal activities including cyber-bullying, computer hacking and radicalisation. Using survey and interview methods over four years, the project will study how adolescents use the Internet daily, and particularly how thi ....Adolescents becoming delinquent online. The project aims to provide a longitudinal criminological study of adolescent Internet use in the world. The Internet is a pervasive influence in young people's lives and is increasingly viewed as a significant factor in the incidence of criminal activities including cyber-bullying, computer hacking and radicalisation. Using survey and interview methods over four years, the project will study how adolescents use the Internet daily, and particularly how this may enable or encourage delinquency on and off-line. This project is expected to benefit national security, law enforcement and crime prevention and enhance public safety and social cohesion.Read moreRead less
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Justice Reinvestment in Australia: conceptual foundations for criminal justice innovation. This project will examine the characteristics of Justice Reinvestment programs used in other countries which reduce spending on prisons and reinvest the savings in high crime communities to reduce crime and build community services. This study will analyse whether such programs can be developed in the Australian context.
Violence, Risk and Safety: The Changing Face of Australian Criminal Laws . Criminal laws have been radically transformed to keep Australians safe from violence. This project aims to complete the first national study of how and why criminal laws have proliferated and diversified so significantly. It will employ novel conceptual tools for investigating the 'drivers', ‘processes’ and ‘modalities’ of criminalisation, and complete socio-legal studies of sexual and domestic violence, homicide, alcohol ....Violence, Risk and Safety: The Changing Face of Australian Criminal Laws . Criminal laws have been radically transformed to keep Australians safe from violence. This project aims to complete the first national study of how and why criminal laws have proliferated and diversified so significantly. It will employ novel conceptual tools for investigating the 'drivers', ‘processes’ and ‘modalities’ of criminalisation, and complete socio-legal studies of sexual and domestic violence, homicide, alcohol-related violence, public disorder and the activities of criminal groups. The intended outcome is new knowledge about the causes and effects of innovation in criminal law-making. This research can benefit future public debate, policy development and law reform decisions about the role of criminalisation in enhancing safety.Read moreRead less
Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statis ....Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statistical methods provide the opportunity to close this gap. The outcome will be identification of many genomic variants causing variation in complex traits. This will benefit scientific understanding of complex traits and the ability to predict traits for individuals from their genome sequence.Read moreRead less
What makes a community resilient? Examining changes in the adaptive capacities of Brisbane suburbs before and after the 2011 flood. This project will be the first study to examine the key community processes and structures associated with community resilience both before and after the 2011 Brisbane floods. Drawing on a longitudinal study of Brisbane suburbs, it will critically assess the conditions under which suburban communities respond to and recover from a major disaster.
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less
Anti-Cancer Natural Products: Total Synthesis and Biological Evaluation of Lasonolide A and Analogues. One in three men and one in four women in Australia will be diagnosed with cancer before they reach 75. Cancer is a leading cause of death within this country with 28% of deaths each year due to this disease. Although there have been advances in the treatment of various forms of cancer there remains a pressing need for new therapies with improved potency, selectivity and reduced side effects. T ....Anti-Cancer Natural Products: Total Synthesis and Biological Evaluation of Lasonolide A and Analogues. One in three men and one in four women in Australia will be diagnosed with cancer before they reach 75. Cancer is a leading cause of death within this country with 28% of deaths each year due to this disease. Although there have been advances in the treatment of various forms of cancer there remains a pressing need for new therapies with improved potency, selectivity and reduced side effects. This project will provide new compounds of potential clinical use in the treatment of cancer, thereby aiding the large population of Australians who will be affected by this disease. Furthermore, the new advanced materials produced by this project will aid in the study of biochemical processes involved in cancer.Read moreRead less
Improved detection and characterisation of breast cancer using magnetic resonance imaging, and novel image analysis and pattern recognition techniques. Breast cancer is a leading cause of death in Australian women. With no clear cause, one mainstay of management has been early detection. Newer medical imaging technologies such as magnetic resonance imaging require complex analysis to achieve their full benefit. Should the computationally demanding analyses of these images provide more sensitive ....Improved detection and characterisation of breast cancer using magnetic resonance imaging, and novel image analysis and pattern recognition techniques. Breast cancer is a leading cause of death in Australian women. With no clear cause, one mainstay of management has been early detection. Newer medical imaging technologies such as magnetic resonance imaging require complex analysis to achieve their full benefit. Should the computationally demanding analyses of these images provide more sensitive and specific detection of early cancers, the potential reductions in morbidity and mortality from breast cancer will be of immense value. Successful implementation of the proposed project will further enhance Australia's position as a world leader in biomedical research and application of computational technologies to health problems.Read moreRead less