Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989759
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting a ....Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting and Maintaining Good Health and Frontier Technologies for Building and Transforming Australian Industries and will generate science to support and stimulate domestic industry, enhance the domestic knowledge base and international research profile, train students and future synchrotron scientists and foster domestic and international collaborations.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100437
Funder
Australian Research Council
Funding Amount
$417,237.00
Summary
Nanobubbles for effective and energy efficient water treatment. This project aims to produce new knowledge for developing ozone nanobubbles as a technological option for the water industry where commercially suitable technologies are unavailable. Australian water utilities have identified two key challenges: destruction of micropollutants and natural organic matter in recycled and reservoir water, respectively. New knowledge from the project will allow these water utilities to utilise the extrao ....Nanobubbles for effective and energy efficient water treatment. This project aims to produce new knowledge for developing ozone nanobubbles as a technological option for the water industry where commercially suitable technologies are unavailable. Australian water utilities have identified two key challenges: destruction of micropollutants and natural organic matter in recycled and reservoir water, respectively. New knowledge from the project will allow these water utilities to utilise the extraordinary properties of nanobubbles and the strong oxidation capability of ozone for effective and energy efficient water treatment. Tech-transfer to the industry is guaranteed through a scientifically designed pilot plant for benchmarking against the current state of the art ozonation process and reverse osmosis.Read moreRead less
Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an ....Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an animal health and production problem in the life of the commercial pig. This project will generate new knowledge on early life management to endow stress resilience in pigs, with expected benefits for animal welfare, farm productivity and profitability.Read moreRead less
MICROFABRICATED DEVICES: A SIGNIFICANT ADVANCE FOR THE DETECTION AND MOLECULAR ANALYSES OF CIRCULATING CANCER CELLS?
Funder
National Health and Medical Research Council
Funding Amount
$422,107.00
Summary
Using advanced microfabrication concepts, this project aims to develop a platform technology able to capture tumour cells circulating in the blood of cancer patients. Although present only in extremely small numbers, these cells provide invaluable insights into the pathophysiology of the disease and consequently provide vital diagnostic and prognostic information. Molecular analyses of these cancer cells could ultimately enable the design of improved and personalized cancer treatment.
Sustainable Hydrogen Production from Used Water. The project aims to address the pressing challenge of water scarcity in hydrogen production by developing an innovative approach of using used water as the feed for water electrolysis. The project will result in an in-depth understanding of the impacts of water impurities in used water on the performance and durability of water electrolysers, and develop guidelines for the design of highly durable water electrolysers and the operation and upgrade ....Sustainable Hydrogen Production from Used Water. The project aims to address the pressing challenge of water scarcity in hydrogen production by developing an innovative approach of using used water as the feed for water electrolysis. The project will result in an in-depth understanding of the impacts of water impurities in used water on the performance and durability of water electrolysers, and develop guidelines for the design of highly durable water electrolysers and the operation and upgrade of existing wastewater treatment plants. The project will advance the practical applications of water electrolysis for scalable and sustainable hydrogen production and help Australia secure a leading position in the global emerging hydrogen economy.Read moreRead less
Pushing AR Toward Better Outcomes In Breast And Prostate Cancers
Funder
National Health and Medical Research Council
Funding Amount
$998,754.00
Summary
Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives ....Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives.Read moreRead less
Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously gen ....Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously generate nitric oxide, but not for extended periods of time. This project’s approach is significant because it avoids bacterial resistance to the nitric oxide treatment. Applications of this technology may include removing biofilms from environments such as water filtration devices and consumable medical surfaces.Read moreRead less
Achieving Nitrite Shunt For Mainstream Sewage Treatment Using Human Waste. This project aims to develop a novel technology to achieve mainstream nitrogen removal from domestic sewage via nitrite shunt. Nitrite shunt can reduce energy consumption and promote energy recovery compared with the conventional nitrogen removal process. However, it is difficult to inactivate nitrite-oxidising bacteria, which is a key barrier for achieving nitrite shunt. By advancing the underpinning science and introduc ....Achieving Nitrite Shunt For Mainstream Sewage Treatment Using Human Waste. This project aims to develop a novel technology to achieve mainstream nitrogen removal from domestic sewage via nitrite shunt. Nitrite shunt can reduce energy consumption and promote energy recovery compared with the conventional nitrogen removal process. However, it is difficult to inactivate nitrite-oxidising bacteria, which is a key barrier for achieving nitrite shunt. By advancing the underpinning science and introducing a novel technology that innovatively harnesses a human waste, the project expects to remove the barrier. Expected outcomes will support the transformation of sewage treatment plants into net-zero energy generators. This should provide economic, environmental and energy benefits for Australia’s water and energy sectors.Read moreRead less
Mitigation of silica nanoparticle scaling in water treatment. This project aims to develop strategies to mitigate silica scaling at coal seam gas (CSG) water treatment facilities. CSG is adsorbed to the surface of coal along fractures and cleats and released when pressure is reduced by removal of groundwater, which has chemistry specific to the region from which it is extracted. Desalination of produced water is severely impacted by mineral scaling on reverse osmosis membranes. This project will ....Mitigation of silica nanoparticle scaling in water treatment. This project aims to develop strategies to mitigate silica scaling at coal seam gas (CSG) water treatment facilities. CSG is adsorbed to the surface of coal along fractures and cleats and released when pressure is reduced by removal of groundwater, which has chemistry specific to the region from which it is extracted. Desalination of produced water is severely impacted by mineral scaling on reverse osmosis membranes. This project will consider silica and silica-rich nanoparticles in concert with cations and organics, with the aim of better managing cations so to facilitate nanoparticle lubrication. Project outcomes may include more productive use of assets, improved pre-treatment infrastructure to support reverse osmosis operation, and the environmental benefits of reduced chemical waste and increased water recovery.Read moreRead less