Australian Prostate Cancer Collaboration (APCC) Bio-Resource
Funder
National Health and Medical Research Council
Funding Amount
$2,310,000.00
Summary
The Australian Prostate Cancer Collaboration (APCC), supported by the Commonwealth Bank, Prostate Cancer Foundation of Australia and Andrology Australia, has been developing an Australia-wide network of prostate tissue banks and associated clinical databases for the past 3 years. The concept of this innovative project is to establish “nodes” or branches of the tissue bank in each State where tissues are collected and to coordinate the use of this material from a central committee or “head office ....The Australian Prostate Cancer Collaboration (APCC), supported by the Commonwealth Bank, Prostate Cancer Foundation of Australia and Andrology Australia, has been developing an Australia-wide network of prostate tissue banks and associated clinical databases for the past 3 years. The concept of this innovative project is to establish “nodes” or branches of the tissue bank in each State where tissues are collected and to coordinate the use of this material from a central committee or “head office”. A website has been established (www.apccbioresource.org.au) that is the national face of this ‘virtual’ national tissue bank and 7 State-based tissue bank consortiums are participating in this venture. The goal of this ‘virtual bank’ or network is to further enhance the national research effort by facilitating greater collaboration nationally and providing better access to, and optimal utilisation of, the clinical material available to facilitate improvements in prostate cancer management. Operational support for the nodes is critical for the success of a national Bio-Resource.Read moreRead less
The Breast Cancer Biospecimen Resource will consist of stored samples of the majority of newly diagnosed breast cancers in NSW and through the Australian and New Zealand Breast Cancer Trials Group together with accurate, prospectively tracked clinical data on each specimen. This facility will serve as a model for extension of similar procedures to other common Australian cancers including cancers of the lung, bowel, prostate and melanoma. Research that is facilitated by this Resource holds real ....The Breast Cancer Biospecimen Resource will consist of stored samples of the majority of newly diagnosed breast cancers in NSW and through the Australian and New Zealand Breast Cancer Trials Group together with accurate, prospectively tracked clinical data on each specimen. This facility will serve as a model for extension of similar procedures to other common Australian cancers including cancers of the lung, bowel, prostate and melanoma. Research that is facilitated by this Resource holds real promise for improving patient selection for treatment. This will return a significant humanitarian and cost saving benefit. In addition this advance would also maximise the benefit of population mammographic screening.Read moreRead less
The Trans Tasman Radiation Oncology Group is an experienced research group conducting cancer clinical trials involving radiotherapy (RT) in order to improve cure rates, quality of life and to reduce side-effects of treatment. Fifty per cent of all cancer patients need RT as part of their treatment. The aim of the proposal is to strengthen the quality and safety of RT trials by (a) enabling rapid review and checking of treatment by electronic means and (b) improve trial design.
Availability of ethically consented, clinically annotated human cancer tissue is a key determinant of the international competitiveness of Australian biomedical researchers. This project will provide a structured national network to collect, process and disseminate tumour tissue; strategically target specific tumour types such as mesothelioma and rare paediatric tumours that can only be collected in substantial numbers through the formation of such a network and provide infrastructure that can b ....Availability of ethically consented, clinically annotated human cancer tissue is a key determinant of the international competitiveness of Australian biomedical researchers. This project will provide a structured national network to collect, process and disseminate tumour tissue; strategically target specific tumour types such as mesothelioma and rare paediatric tumours that can only be collected in substantial numbers through the formation of such a network and provide infrastructure that can be contracted by clinical and translational researchers. The project builds on a wealth of experience in tissue banking, large-scale molecular genetic and genomic studies in breast, ovarian, colorectal cancers and mesothelioma, and on an established consortium _ the Australasian Biospecimen Network.Read moreRead less
Australian Ovarian Cancer Study (AOCS): A Multidisciplinary Ovarian Cancer Resource For The Genomic Era
Funder
National Health and Medical Research Council
Funding Amount
$1,404,500.00
Summary
Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level, to identify genetic risk factors, or to understand the interaction of genes and environment. Recognizing that a large collaborative study was the only way to achieve sufficient power to address major translational questions in ovarian cancer, the Australian Ovarian Cancer Study was established and is now the largest study of its kind in the world. This pro ....Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level, to identify genetic risk factors, or to understand the interaction of genes and environment. Recognizing that a large collaborative study was the only way to achieve sufficient power to address major translational questions in ovarian cancer, the Australian Ovarian Cancer Study was established and is now the largest study of its kind in the world. This proposal aims to maintain and add value to this unique resource for ovarian cancer research.Read moreRead less
Schizophrenia research is constrained by difficulty in achieving large samples for research into the causal role of genetic factors in this complex disease. The Australian Schizophrenia Research Bank will comprise a large sample of schizophrenia probands (N-1000 initially) and their first-degree relatives (N-2 per proband) with linked clinical, cognitive, neuroanatomical and genetic data. These data will be available to Australian researchers to study the genetic underpinnings of this disease an ....Schizophrenia research is constrained by difficulty in achieving large samples for research into the causal role of genetic factors in this complex disease. The Australian Schizophrenia Research Bank will comprise a large sample of schizophrenia probands (N-1000 initially) and their first-degree relatives (N-2 per proband) with linked clinical, cognitive, neuroanatomical and genetic data. These data will be available to Australian researchers to study the genetic underpinnings of this disease and its subtypes, leading to improved treatments and preventative strategies.Read moreRead less
This proposal is to build a new national resource for medical research that will both underpin and enhance the national health and medical research effort in Australia by systematically enabling world-class biobanking capacities and hence the population-based resources in WA for genetics epidemiological research. The WA DNA Bank will also provide national access to WA biospecimen resources, and will facilitate collaboration and research into national priority diseases of childhood and adulthood.