Molecular Characterisation Of Early Precursor Lesions Of A Novel Ñserrated Pathwayî Of Colorectal Cancer Using Gene Expression And Proteomics.
Funder
National Health and Medical Research Council
Funding Amount
$318,338.00
Summary
In Australia, CRC is the second highest cause of all cancer-related deaths. If detected early, CRC has a high success rate of cure, but a percentage of precursor lesions escape detection and show aggressive clinical behaviour to progress to CRC. These are difficult to diagnosis with existing technologies. We aim to understand the biology behind sessile serrated adenoma pathways and hence enhance early detection, diagnosis and treatments strategies.
The Role And Underlying Mechanisms Of Constitutional Epigenetic Silencing In Cancer Predisposition
Funder
National Health and Medical Research Council
Funding Amount
$218,617.00
Summary
Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.
Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of di ....Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of disease.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101550
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Understanding multidrug resistance: identifying the molecular basis of substrate and inhibitor transport by P-glycoprotein. Chemotherapy resistance causes 90 per cent of cancer deaths and is commonly triggered by the increased activity of P-glycoprotein, which controls the cellular clearance of drugs. This project will determine how P-glycoprotein recognises and transports drugs, essential knowledge for the design of anticancer agents that can stop chemotherapy resistance.
Persistence and transformation in Ancestral Oceanic Society: the archaeology of the first 1500 years in the Vanuatu archipelago. Supporting research programs with smaller Pacific Island neighbours fosters Australia's relationship with those countries generally. The project will contribute to regional capacity building in the areas of archaeology, heritage studies and management. This research will enhance understanding of the region's deep human past and the way it articulates historically with ....Persistence and transformation in Ancestral Oceanic Society: the archaeology of the first 1500 years in the Vanuatu archipelago. Supporting research programs with smaller Pacific Island neighbours fosters Australia's relationship with those countries generally. The project will contribute to regional capacity building in the areas of archaeology, heritage studies and management. This research will enhance understanding of the region's deep human past and the way it articulates historically with the rest of the world. It will advance Australia's understanding of its nearest neighbours as well as provide those neighbours with information that goes towards strengthening national identity. The proposed research has direct relevance to ongoing debates within Australian and World archaeology and related disciplines, and fosters international collaborative links. Read moreRead less
Northern Vanuatu as a Pacific Crossroads: The archaeology of discovery, interaction and the emergence of the ethnographic present. The project addresses the National Research Priority Goal of "Understanding our Region and the World". Supporting research programs with smaller Pacific Island neighbours such as Vanuatu fosters Australia's relationship with those countries generally. This research will strengthen our knowledge of the region's deep human past. It will advance Australia's understandin ....Northern Vanuatu as a Pacific Crossroads: The archaeology of discovery, interaction and the emergence of the ethnographic present. The project addresses the National Research Priority Goal of "Understanding our Region and the World". Supporting research programs with smaller Pacific Island neighbours such as Vanuatu fosters Australia's relationship with those countries generally. This research will strengthen our knowledge of the region's deep human past. It will advance Australia's understanding of its nearest neighbours as well as provide those neighbours with information they can use to shape their own views of their past and its relationship to their present. The proposed research has direct relevance to on-going debates within world archaeology and related disciplines.Read moreRead less
Indian Textile Technology as archaeological evidence for population movements in Early Southeast Asia. This project uses archaeological textiles to investigate population movements in the late prehistoric period of Southeast Asia. It involves collaborative links between researchers from the Institute of Archaeology in Vietnam, the Centre for Southeast Asian Prehistory in Ho Chi Minh City, the Fine Arts Department of Thailand and museums and archaeological institutions in South India. It not only ....Indian Textile Technology as archaeological evidence for population movements in Early Southeast Asia. This project uses archaeological textiles to investigate population movements in the late prehistoric period of Southeast Asia. It involves collaborative links between researchers from the Institute of Archaeology in Vietnam, the Centre for Southeast Asian Prehistory in Ho Chi Minh City, the Fine Arts Department of Thailand and museums and archaeological institutions in South India. It not only profiles Australian expertise in Southeast Asia but facilitates high levels of communication and the exchange of ideas. Read moreRead less
A study of ancient jade trading networks in prehistoric southern China and Southeast Asia, 3000 BC to AD 500. This project will make a significant intellectual contribution to enhancing Australia's awareness of the histories of neighbouring populations in Southeast Asia that in total exceed 750 million people. It will thus contribute to a better understanding of our region and the world. The project will also benefit the indigenous populations and future researchers of neighbouring Asian countri ....A study of ancient jade trading networks in prehistoric southern China and Southeast Asia, 3000 BC to AD 500. This project will make a significant intellectual contribution to enhancing Australia's awareness of the histories of neighbouring populations in Southeast Asia that in total exceed 750 million people. It will thus contribute to a better understanding of our region and the world. The project will also benefit the indigenous populations and future researchers of neighbouring Asian countries, through research collaboration and the dissemination of original research results, enhancing Australia's status as a supportive neighbour in the region.Read moreRead less