Investigation Of The Low Dose UV G2 Phase Checkpoint And Its Potential Exploitation In The Treatment Of Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$35,085.00
Summary
The research aims to indentify the role UV exposure contributes to the development of melanoma and if this knowledge can be used to develop new methods in the prevention and treatment of this disease
Examining The Role Of HIF-1a And Snail-2 In Radiosensitivity Of Oropharyngeal Squamous Cell Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$78,492.00
Summary
Human papillomavirus (HPV)-induced oropharyngeal squamous cell carcinoma has a significantly better prognosis than that caused by tobacco and/or alcohol. The favorable prognosis is due to a better response to treatment with radiation therapy and chemotherapy but the exact mechanisms are still not clear. This project will investigate these mechanisims at the molecular level and ultimately it will lead us to the development of strategies to improve the response of both HPV and non-HPV induced orop ....Human papillomavirus (HPV)-induced oropharyngeal squamous cell carcinoma has a significantly better prognosis than that caused by tobacco and/or alcohol. The favorable prognosis is due to a better response to treatment with radiation therapy and chemotherapy but the exact mechanisms are still not clear. This project will investigate these mechanisims at the molecular level and ultimately it will lead us to the development of strategies to improve the response of both HPV and non-HPV induced oropharyngeal cancer to radiation therapy.Read moreRead less
Genetic And Epigenetic Mechanisms Determining Responses To Therapies In Non-small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$22,677.00
Summary
Lung cancer results in more cancer related deaths than any other cancer. The aim of this study is to identify prognostic and predictive markers for patients with non-small cell lung cancer (NSCLC) treated with chemotherapy, palliative radiotherapy and also novel targeted agents. This will help to better utilise these treatments and hopefully improve outcomes in patients with NSCLC.
Determining Patients And Doctors Preferences For Chemotherapy And Incorporating Them Into Clinical Decision-making
Funder
National Health and Medical Research Council
Funding Amount
$87,234.00
Summary
Chemotherapy improves survival in early lung cancer and advanced ovarian cancer but has significant side effects. Recent advances in chemotherapy have not been widely adopted because of differing opinions about whether the benefits of these treatments outweigh their harms. This research program will determine the benefits that patients and their doctors judge necessary to make these treatments worthwhile, and how best to incorporate this information into clinical discussions and decision-making.