Discovery Early Career Researcher Award - Grant ID: DE140101530
Funder
Australian Research Council
Funding Amount
$372,744.00
Summary
Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotr ....Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotron femur images are taken in loaded and unloaded conditions. Cortical strain and fracture are measured, replicating possible multiaxial loads. Micro finite-element models will be used to study the contribution that the bone tissue architecture, tissue structure and activity types make to the fracture. The resulting knowledge will have future orthopaedic applications.Read moreRead less
Clean technologies for the synthesis and purification of a biohybrid and biodegradable polymer. The project aims to transform an Australian industry in the forefront of the global market for manufacturing biodegradable polymers and boost export earnings derived from CO2 based biohybrid polymers. The project will develop cost-effective and clean methods for processing CO2 based polymers and demonstrate its potential for packaging and biomedical applications.
A novel approach to the design and fabrication of biomimetic and biocompatible Ti-Ta implants by additive manufacturing. A large number of the Australian population suffer various types of bone issues arising from either age-related degenerative bone problems or injuries from accidents, sports and other activities. As the number of joint replacements performed in Australia increases, it is important to reduce the rate of implant failure. This project aims to address this critical issue by combin ....A novel approach to the design and fabrication of biomimetic and biocompatible Ti-Ta implants by additive manufacturing. A large number of the Australian population suffer various types of bone issues arising from either age-related degenerative bone problems or injuries from accidents, sports and other activities. As the number of joint replacements performed in Australia increases, it is important to reduce the rate of implant failure. This project aims to address this critical issue by combining unique multi-scale structural design, alloy development, 3D printing, modelling and tissue engineering to develop bone-like biomimetic titanium implants with superior structural, mechanical and biological compatibility with bone. The outcomes aim to contribute to both healthcare and manufacturing industries, as well as improving the quality of life for Australians.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100129
Funder
Australian Research Council
Funding Amount
$530,721.00
Summary
State-of-the-art atomic force microscopy facilities for South Australia. This project aims to transform our national capability in nano-(bio)characterisation by establishing a state-of-the-art atomic force microscopy (AFM) facility in South Australia. The facility will provide unparalleled capabilities not currently available in Australia and will catapult knowledge in multiple fields, from critical minerals and clean energy to mechanobiology. Expected outcomes include more efficient and eco-fri ....State-of-the-art atomic force microscopy facilities for South Australia. This project aims to transform our national capability in nano-(bio)characterisation by establishing a state-of-the-art atomic force microscopy (AFM) facility in South Australia. The facility will provide unparalleled capabilities not currently available in Australia and will catapult knowledge in multiple fields, from critical minerals and clean energy to mechanobiology. Expected outcomes include more efficient and eco-friendly resource recovery and energy production, future foods and cures, and advanced (bio)materials. The project will strengthen and amplify Australia’s capacity and global leadership to translate fundamental nano-scale phenomena and properties into innovative materials, technologies, and processes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100139
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
A Hot Isostatic Press (HIP) for aerospace and biomedical component processing. This facility will provide a hot isostatic press of sufficiently large capacity to maximise production efficiencies in aerospace and biomedical applications through net shape manufacturing. The facility will be able to process small components or prototypes which will behave in a manner similar to larger scale components.
Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffo ....Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffolds with a superior ability to promote the development of new tissue, and 2) create surfaces that will enable us to answer fundamental scientific questions regarding cell adhesion and cell/material interactions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100188
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Epitaxial growth facility for advanced materials. An advanced materials fabrication facility accessible to all Australian researchers will be established. This will allow crystal growth at the atomic level for novel materials with applications including fundamental physics, nanocomposites, energy storage and conversion systems, and solar cells.
Bioengineered bioscaffolds for Achilles tendinopathy treatment. The purpose of the project is to improve outcomes following the surgical treatment of Achilles tendinopathy. The expected outcome is the development in animals of new ways to design tissue engineered bioscaffolds for the surgical repair of Achilles tendinopathy.
Novel Strategy For The Treatment Of Large Bone Defects Using A Unique Biomaterial With Tailored Microstructure
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
There is a rapidly increasing and pressing medical need for the development of synthetic implants that can regenerate large amounts of lost or diseased bone. This project will produce a unique implant with optimal mechanical and biological performance, which represents a viable alternative to bone grafting with broad applications for the repair of large or challenging bone defects. Such an achievement will produce significant healthcare benefits and improved long-term outcomes.