Effects Of Replacement And Withdrawal Of Testosterone In Human Males On Muscle, Bone And Fat
Funder
National Health and Medical Research Council
Funding Amount
$156,682.00
Summary
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases well being and contributes to muscle weakness, bone fragility and weight gain. Cutting edge technology will be used to help explain how AD may relate to these negative effects, particularly on muscle function. Given the importance of aging, frailty, osteoporosis and obesity, understanding the role of hormones in these conditions may have major implications for prevention and treatment.
Prediction Of Ventricular Arrhythmias And Prevention Of Sudden Cardiac Death Following Revascularised Acute Myocardial Infarction.
Funder
National Health and Medical Research Council
Funding Amount
$117,270.00
Summary
Acute myocardial infarction (AMI) is a leading cause of death in Australia. Patients with coronary artery disease and impaired left ventricular function are at increased risk of heart failure, reinfarction and sudden cardiac death (SCD). This research will evaluate optimal methods to identify patients at risk for SCD following AMI using echocardiographic, MRI, and electrophysiological characteristics, and improve survival by early identification and management of these high-risk patients.
In Vivo Studies On Ventriculo-vascular Coupling And The Role Of Aortic Pressure Wave Morphology On Coronary Blood Flow
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Heart disease is a leading cause of death and disability in Australia. Conditions resulting in reduced blood flow to the heart are particularly common and dangerous. Despite significant progress, we still do not understand exactly how changes in heart function and the aorta (the major artery arising from the heart) affect blood flow to the heart. This study will utilise sophisticated new techniques to look at the interactions between heart function, pressure in the aorta and coronary blood flow
The Impact Of Strength Training On Calf Muscle Structure And Function In Youth And Adolescents With Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$89,857.00
Summary
Muscle spasticity is a primary cause of disability in individuals with cerebral palsy; however their muscles also do not develop properly: they are weak and resistant to stretch. Strength training causes muscle adaptations that increase strength and decrease stiffness. This study will examine the impact of a strength training intervention on muscle structure and function using innovative imaging techniques, motion analysis and measures of muscle strength and stretch, translating into better cons ....Muscle spasticity is a primary cause of disability in individuals with cerebral palsy; however their muscles also do not develop properly: they are weak and resistant to stretch. Strength training causes muscle adaptations that increase strength and decrease stiffness. This study will examine the impact of a strength training intervention on muscle structure and function using innovative imaging techniques, motion analysis and measures of muscle strength and stretch, translating into better conservative intervention planning.Read moreRead less
Feasibility, Safety, Adherence, And Efficacy For High Intensity Interval Training In A Hospital-Initiated Rehabilitation Program For Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$75,779.00
Summary
This project aims to investigate if high intensity interval training can be successfully integrated into a hospital-based cardiac rehabilitation program as a practical and safe alternative to the usual care exercise protocol (moderate intensity continuous training). We expect high intensity interval training will be a safe and practical option for appropriate patients, and will offer greater improvements in fitness, exercise adherence, cardiovascular risk factors, and intra-abdominal fat.
Smartphone Based Secondary Prevention Program For Patients With Acute Coronary Syndromes: A Randomised Control Trial
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Patients at the highest risk of premature death, heart attacks and re-hospitalization are those with known coronary heart disease. Secondary prevention strategies and cardiac rehabilitation are under-utilised in clinical practice. We aim to close this treatment gap by establishing the role of a smartphone based secondary prevention program in patients who have experienced a heart attack. Our innovative model of care may empower patients to optimise their cardiac health.
Non-Inasive Wave Intensity Analysis In Paediatric Congenital Heart Disease: A Novel Application Of Cardiac Magnetic Resonance Imaging
Funder
National Health and Medical Research Council
Funding Amount
$136,861.00
Summary
Alterations in heart pumping function, or blood vessel structure, can limit the supply of blood and oxygen to the body. Wave Intensity Analysis (WIA) is a new way of characterising these interactions with great precision. Up until now, WIA has been performed in adult and animal studies using mainly invasive techniques. This project will develop a non-invasive method for WIA using cardiac Magnetic Resonance Imaging, to gain new insights into congenital heart disease in children.
The Haemodynamic Effects Of Cardiac Compression By Large Hiatal Hernia And The Relationship To Exercise Impairment.
Funder
National Health and Medical Research Council
Funding Amount
$117,270.00
Summary
Large hiatal herniae (HH) often cause debilitating exercise intolerance - the mechanism of which is unknown. This project will define the functional and haemodynamic significance of cardiac compression in patients with large HH, providing new insights into the mechanism of exercise impairment in these patients as well as clinical tools for pre-operative selection of patients likely to benefit most from surgical repair.
Patellofemoral Joint Osteoarthritis: The Effect Of Foot Orthoses
Funder
National Health and Medical Research Council
Funding Amount
$99,002.00
Summary
Despite the burden of patellofemoral joint osteoarthritis (PFJ OA), there is a paucity of evidence for conservative treatments. This project aims to determine the functional features of PFJ OA and develop a clinical tool to enable identification of features associated with PFJ OA. A randomised controlled trial will then be conducted utilising a foot orthoses intervention to determine whether foot orthoses improve function and pain in people with PFJ OA.
The Characterisation Of The Functional Regions Of Sarcomeric Alpha-actinins And To Determine How The Absence Of Alpha-actinin-3 Influences Human Skeletal Muscle Function And Metabolism.
Funder
National Health and Medical Research Council
Funding Amount
$95,313.00
Summary
We are studying a muscle protein called a-actinin-3. This protein is absent in approximately one billion people worldwide. A-actinin-3 is associated with athletic performance. Our goal is to explore how the absence of a-actinin-3 influences human skeletal muscle function and metabolism. We will be studying a-actinin-3 deficiency using a mouse model.